The Resource Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex, by Diana Rose Roberts

Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex, by Diana Rose Roberts

Label
Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex
Title
Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex
Statement of responsibility
by Diana Rose Roberts
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Plants are sessile by nature; because of this they have evolved many strategies to cope with the diverse environmental stimuli they encounter in nature. One such strategy is the phototropic response by which plants reorient the aerial organs toward and roots away from directional blue light. The blue light response can be broken down into three general steps: perception of light, signal leading to the lateral redistribution of auxin, and initiation of a differential growth response (resulting in phototropic curvature). Loss-of-function genetic screens have identified several key proteins involved in phototropic signal-response, including the primary photoreceptors, phototropins 1 and 2 (phot1 and phot2), and a BTB protein, NPH3. Recent studies in our laboratory have shown that NPH3, a phot1 interacting protein, can also interact with Cullin 3 (Cul3) as a substrate adapter in a Cul3-based E3 ubiquitin ligase designated CRL3NPH3. We have shown that the CRLNPH3 complex is necessary for the mono/multi- and polyubiquitination of phot1 under high fluence rate conditions in addition to the mono/multiubiquitination of phot1 under low fluence rate conditions. Preliminary evidence suggested that mono/multiubiquitination of phot1 is necessary for BL dependant receptor internalization which appears to be critical to phot1 mediated signal transduction. Interestingly, the photoreceptor is internalized in the absence of monoubiquitination signal, but recent evidence suggests that the mono/multiubiquitination signal is responsible for targeting the photoreceptor and is necessary for phototropism. We propose that phot-dependent phototropism is modulated in large part through the ubiquitination of phot1 by CRL3NPH3 and the subsequent internalization of phot1. We are currently working to elucidate the role of mono/multiubiquitination in phot1 internalization and receptor function. These ubiquitination responses represent the blue light-induced signal transduction events occurring prior to (and presumably required for) auxin redistribution, auxin-dependent changes in transcription, and development of differential growth. --public.pdf
Cataloging source
MUU
http://library.link/vocab/creatorDate
1984-
http://library.link/vocab/creatorName
Roberts, Diana Rose
Degree
Ph. D.
Dissertation note
Thesis
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1966-
http://library.link/vocab/relatedWorkOrContributorName
Liscum, Emmanuel
http://library.link/vocab/subjectName
  • Cryptochrome
  • Plant cellular signal transduction
  • Cryptochrome
  • Plant cellular signal transduction
Label
Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex, by Diana Rose Roberts
Instantiates
Publication
Note
  • "A Dissertation Presented to The Faculty of the Graduate School At the University of Missouri In Partial Fulfillment Of the Requirements for the Degree Doctorate of Philosophy."
  • Doctoral supervisor: Dr. Emmanuel Liscum, III
  • Vita
Bibliography note
Includes bibliographical references (pages 176-184)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
871330719
Extent
1 online resource (xi, 185 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)871330719
Label
Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL([superscript] 3NPH3) ubiquitin ligase complex, by Diana Rose Roberts
Publication
Note
  • "A Dissertation Presented to The Faculty of the Graduate School At the University of Missouri In Partial Fulfillment Of the Requirements for the Degree Doctorate of Philosophy."
  • Doctoral supervisor: Dr. Emmanuel Liscum, III
  • Vita
Bibliography note
Includes bibliographical references (pages 176-184)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
871330719
Extent
1 online resource (xi, 185 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)871330719

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