The Resource Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
Resource Information
The item Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from 1 library branch.
- Summary
- Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed
- Language
- eng
- Extent
- 1 online resource (viii, 364 pages)
- Contents
-
- Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1 ... Introduction; 1.2 ... What's in a Name?; 1.3 ... Many Sources, Uses, and Functions; 1.4 ... How Old Are ''Antibiotics''?; 1.5 ... Antibiotic Myths; 1.6 ... Mode of Action and Evolution of Targets; 1.7 ... Parallel Chemical and Protein Evolution; 1.8 ... Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1 ... Introduction
- 2.2 ... Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3 ... Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4 ... Issues with Clostridium difficileClostridium difficile Infections; 2.5 ... Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1 ... Introduction; 3.2 ... MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
- 3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3 ... Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
- 3.3.3.3 Klebsiella pneumoniae3.4 ... The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5 ... Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
- 4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1 ... Introduction; 4.2 ... Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
- Isbn
- 9783642399671
- Label
- Antimicrobials : new and old molecules in the fight against multi-resistant bacteria
- Title
- Antimicrobials
- Title remainder
- new and old molecules in the fight against multi-resistant bacteria
- Statement of responsibility
- Flavia Marinelli, Olga Genilloud, editors
- Language
- eng
- Summary
- Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed
- Cataloging source
- GW5XE
- Dewey number
- 615.7/92
- Illustrations
- illustrations
- Index
- index present
- LC call number
- RM267
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
- QV 250
- http://library.link/vocab/relatedWorkOrContributorName
-
- Marinelli, Flavia
- Genilloud, Olga
- http://library.link/vocab/subjectName
-
- Anti-infective agents
- Anti-Infective Agents
- MEDICAL
- Anti-infective agents
- Label
- Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1 ... Introduction; 1.2 ... What's in a Name?; 1.3 ... Many Sources, Uses, and Functions; 1.4 ... How Old Are ''Antibiotics''?; 1.5 ... Antibiotic Myths; 1.6 ... Mode of Action and Evolution of Targets; 1.7 ... Parallel Chemical and Protein Evolution; 1.8 ... Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1 ... Introduction
- 2.2 ... Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3 ... Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4 ... Issues with Clostridium difficileClostridium difficile Infections; 2.5 ... Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1 ... Introduction; 3.2 ... MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
- 3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3 ... Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
- 3.3.3.3 Klebsiella pneumoniae3.4 ... The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5 ... Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
- 4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1 ... Introduction; 4.2 ... Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
- Control code
- 861746231
- Dimensions
- unknown
- Extent
- 1 online resource (viii, 364 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9783642399671
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-3-642-39968-8
- Other physical details
- illustrations (some color)
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)861746231
- Label
- Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1 ... Introduction; 1.2 ... What's in a Name?; 1.3 ... Many Sources, Uses, and Functions; 1.4 ... How Old Are ''Antibiotics''?; 1.5 ... Antibiotic Myths; 1.6 ... Mode of Action and Evolution of Targets; 1.7 ... Parallel Chemical and Protein Evolution; 1.8 ... Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1 ... Introduction
- 2.2 ... Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3 ... Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4 ... Issues with Clostridium difficileClostridium difficile Infections; 2.5 ... Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1 ... Introduction; 3.2 ... MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
- 3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3 ... Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
- 3.3.3.3 Klebsiella pneumoniae3.4 ... The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5 ... Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
- 4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1 ... Introduction; 4.2 ... Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
- Control code
- 861746231
- Dimensions
- unknown
- Extent
- 1 online resource (viii, 364 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9783642399671
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-3-642-39968-8
- Other physical details
- illustrations (some color)
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)861746231
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