Coverart for item
The Resource Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors

Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors

Label
Antimicrobials : new and old molecules in the fight against multi-resistant bacteria
Title
Antimicrobials
Title remainder
new and old molecules in the fight against multi-resistant bacteria
Statement of responsibility
Flavia Marinelli, Olga Genilloud, editors
Contributor
Editor
Subject
Language
eng
Summary
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed
Cataloging source
GW5XE
Dewey number
615.7/92
Illustrations
illustrations
Index
index present
LC call number
RM267
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 250
http://library.link/vocab/relatedWorkOrContributorName
  • Marinelli, Flavia
  • Genilloud, Olga
http://library.link/vocab/subjectName
  • Anti-infective agents
  • Anti-Infective Agents
  • MEDICAL
  • Anti-infective agents
Label
Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1 ... Introduction; 1.2 ... What's in a Name?; 1.3 ... Many Sources, Uses, and Functions; 1.4 ... How Old Are ''Antibiotics''?; 1.5 ... Antibiotic Myths; 1.6 ... Mode of Action and Evolution of Targets; 1.7 ... Parallel Chemical and Protein Evolution; 1.8 ... Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1 ... Introduction
  • 2.2 ... Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3 ... Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4 ... Issues with Clostridium difficileClostridium difficile Infections; 2.5 ... Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1 ... Introduction; 3.2 ... MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
  • 3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3 ... Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
  • 3.3.3.3 Klebsiella pneumoniae3.4 ... The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5 ... Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
  • 4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1 ... Introduction; 4.2 ... Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
Control code
861746231
Dimensions
unknown
Extent
1 online resource (viii, 364 pages)
File format
unknown
Form of item
online
Isbn
9783642399671
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-642-39968-8
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)861746231
Label
Antimicrobials : new and old molecules in the fight against multi-resistant bacteria, Flavia Marinelli, Olga Genilloud, editors
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1 ... Introduction; 1.2 ... What's in a Name?; 1.3 ... Many Sources, Uses, and Functions; 1.4 ... How Old Are ''Antibiotics''?; 1.5 ... Antibiotic Myths; 1.6 ... Mode of Action and Evolution of Targets; 1.7 ... Parallel Chemical and Protein Evolution; 1.8 ... Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1 ... Introduction
  • 2.2 ... Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3 ... Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4 ... Issues with Clostridium difficileClostridium difficile Infections; 2.5 ... Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1 ... Introduction; 3.2 ... MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
  • 3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3 ... Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
  • 3.3.3.3 Klebsiella pneumoniae3.4 ... The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5 ... Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
  • 4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1 ... Introduction; 4.2 ... Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
Control code
861746231
Dimensions
unknown
Extent
1 online resource (viii, 364 pages)
File format
unknown
Form of item
online
Isbn
9783642399671
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-642-39968-8
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)861746231

Library Locations

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      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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