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The Resource Appetite and body weight : integrative systems and the development of anti-obesity drugs, edited by Tim C. Kirkham and Steven J. Cooper

Appetite and body weight : integrative systems and the development of anti-obesity drugs, edited by Tim C. Kirkham and Steven J. Cooper

Contributor
Summary
There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication. * Provides an integrative view of the many systems involved in appetite and how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.) * Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts * Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds
Language
eng
Work
Publication
Extent
1 online resource (x, 371 pages)
Contents
  • Introduction and overview
  • Cortical systems involved in appetite and food consumption
  • Nucleus accumbens shell as a model of integrative subcortical forebrain systems regulating food intake
  • Hypothalamic neuropeptides and feeding regulation
  • Brainstem-hypothalamic neuropeptides and the regulation of feeding
  • Gut-brain axis in the control of eating
  • Integration of peripheral adiposity signals and psychological controls of appetite
  • Brain reward systems for food incentives and hedonics in normal appetite and eating disorders
  • Pharmacology of food, taste and learned flavor preferences
  • Role of palatability in control of human appetite: implications for understanding and treating obesity
  • Learned influences on appetite, food choice, and intake: evidence in human beings
  • Gene environment interactions and the origin of the modern obesity epidemic: a novel nonadaptive drift scenario
  • Preclinical developments in antiobesity drugs
  • Clinical investigations of antiobesity drugs
Isbn
9780080466460
Instance
Label
Appetite and body weight : integrative systems and the development of anti-obesity drugs
Title
Appetite and body weight
Title remainder
integrative systems and the development of anti-obesity drugs
Statement of responsibility
edited by Tim C. Kirkham and Steven J. Cooper
Contributor
Subject
Genre
Language
eng
Summary
There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication. * Provides an integrative view of the many systems involved in appetite and how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.) * Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts * Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds
Member of
Cataloging source
OPELS
Dewey number
616.39806
Illustrations
illustrations
Index
index present
LC call number
RC552.O25
LC item number
A66 2007eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2007 A-964
  • WI 102
NLM item number
A6454 2007
http://library.link/vocab/relatedWorkOrContributorName
  • Kirkham, Tim C
  • Cooper, S. J
http://library.link/vocab/subjectName
  • Obesity
  • Appetite
  • Body weight
  • Anti-Obesity Agents
  • Obesity
  • Obésité
  • Appétit
  • Poids corporel
  • MEDICAL
  • Appetite
  • Body weight
  • Obesity
  • Essgewohnheit
  • Physiologie
  • Psychopharmakon
  • Übergewicht
  • Vetzucht
  • Geneesmiddelen
Label
Appetite and body weight : integrative systems and the development of anti-obesity drugs, edited by Tim C. Kirkham and Steven J. Cooper
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and overview -- Cortical systems involved in appetite and food consumption -- Nucleus accumbens shell as a model of integrative subcortical forebrain systems regulating food intake -- Hypothalamic neuropeptides and feeding regulation -- Brainstem-hypothalamic neuropeptides and the regulation of feeding -- Gut-brain axis in the control of eating -- Integration of peripheral adiposity signals and psychological controls of appetite -- Brain reward systems for food incentives and hedonics in normal appetite and eating disorders -- Pharmacology of food, taste and learned flavor preferences -- Role of palatability in control of human appetite: implications for understanding and treating obesity -- Learned influences on appetite, food choice, and intake: evidence in human beings -- Gene environment interactions and the origin of the modern obesity epidemic: a novel nonadaptive drift scenario -- Preclinical developments in antiobesity drugs -- Clinical investigations of antiobesity drugs
Control code
162131324
Dimensions
unknown
Extent
1 online resource (x, 371 pages)
Form of item
online
Isbn
9780080466460
Lccn
2007273988
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
  • 130427:130531
  • 66ea17a4-6471-4fec-ab16-b0f15a6c673c
Specific material designation
remote
System control number
(OCoLC)162131324
Label
Appetite and body weight : integrative systems and the development of anti-obesity drugs, edited by Tim C. Kirkham and Steven J. Cooper
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and overview -- Cortical systems involved in appetite and food consumption -- Nucleus accumbens shell as a model of integrative subcortical forebrain systems regulating food intake -- Hypothalamic neuropeptides and feeding regulation -- Brainstem-hypothalamic neuropeptides and the regulation of feeding -- Gut-brain axis in the control of eating -- Integration of peripheral adiposity signals and psychological controls of appetite -- Brain reward systems for food incentives and hedonics in normal appetite and eating disorders -- Pharmacology of food, taste and learned flavor preferences -- Role of palatability in control of human appetite: implications for understanding and treating obesity -- Learned influences on appetite, food choice, and intake: evidence in human beings -- Gene environment interactions and the origin of the modern obesity epidemic: a novel nonadaptive drift scenario -- Preclinical developments in antiobesity drugs -- Clinical investigations of antiobesity drugs
Control code
162131324
Dimensions
unknown
Extent
1 online resource (x, 371 pages)
Form of item
online
Isbn
9780080466460
Lccn
2007273988
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
  • 130427:130531
  • 66ea17a4-6471-4fec-ab16-b0f15a6c673c
Specific material designation
remote
System control number
(OCoLC)162131324

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