Coverart for item
The Resource Bile acids : toxicology and bioactivity, edited by Gareth Jenkins, Laura J. Hardie

Bile acids : toxicology and bioactivity, edited by Gareth Jenkins, Laura J. Hardie

Label
Bile acids : toxicology and bioactivity
Title
Bile acids
Title remainder
toxicology and bioactivity
Statement of responsibility
edited by Gareth Jenkins, Laura J. Hardie
Contributor
Subject
Genre
Language
eng
Summary
A single source of information, with contributions from worldwide experts, on bile acid toxicology and bioactivity and its role in human disease.
Member of
Cataloging source
UKRSC
Dewey number
  • 612.35
  • 612/.01577
Illustrations
illustrations
Index
index present
LC call number
QP752.B54
LC item number
J46 2008
Literary form
non fiction
NAL call number
QP752.B54
NAL item number
B55 2008
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2008 M-216
  • WI 703
NLM item number
B59754 2008
http://library.link/vocab/relatedWorkOrContributorName
  • Jenkins, Gareth
  • Hardie, Laura J
Series statement
Issues in toxicology
http://library.link/vocab/subjectName
  • Bile acids
  • Bile Acids and Salts
  • Bile Acids and Salts
  • Gallstones
  • Neoplasms
  • Obesity
  • Medical toxicology
  • Medical diagnosis
  • Cellular biology
  • MEDICAL
  • Health and Fitness
  • Chemistry
Summary expansion
Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile acids become associated with disease. This breaching of control mechanisms can occur through dietary means (e.g. in obesity) whereby excessive levels of Bile acids are produced and converted (via the bacterial flora) to damaging secondary Bile acids. Furthermore, lack of re-absorption of Bile acids can lead to liver pathologies. The atypical movement of Bile acids into the oesophagus, stimulated by episodes of reflux, is linked to oesophageal cancer. In recent years there have been tremendous advances in the understanding of the mechanisms behind the toxicity and bioactivity of different Bile acids and these are covered at length in this book. Prior to the publication of this book there was no single source of information on the toxicology and bioactivity properties of Bile acids. The book also uniquely collects all the relevant information together regarding the role of Bile acids in human disease and the mechanisms underlying Bile acid induced pathology. Additionally, as Bile acids are synthesised from cholesterol, there is wide recognition of the role for Bile acids in obesity linked diseases and this is also covered in this new publication. The book is edited by two experts in the field who have been involved in Bile acid research for several years and who are closely involved with major research groups in the UK, Europe and the US actively engaged in Bile acid research. The Editors have brought together world experts in their own fields to discuss the contribution of Bile acids to various disease pathologies, as well as discussing the mechanisms behind their activity. The book details the plethora of biological activities of this fascinating group of naturally occurring chemicals and provides a one-stop reference for scientists wishing to gain a fuller understanding of Bile acid activity and function
Label
Bile acids : toxicology and bioactivity, edited by Gareth Jenkins, Laura J. Hardie
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
An overview of bile-acid synthesis, chemistry and function -- Bile-acid physiology and measurement -- Bile-acid induction of apoptosis in relation to gastrointestinal cancer -- The genotoxicity of bile acids -- Bile acids and colorectal cancer -- Bile acids and oesophageal adenocarcinoma (OA) -- Bile acids and obesity -- The role of bile acids in cholesterol-rich gallstone formation
Control code
319518576
Dimensions
unknown
Extent
1 online resource (xi, 163 pages)
Form of item
online
Isbn
9781847558336
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
t2871
Specific material designation
remote
System control number
(OCoLC)319518576
Label
Bile acids : toxicology and bioactivity, edited by Gareth Jenkins, Laura J. Hardie
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
An overview of bile-acid synthesis, chemistry and function -- Bile-acid physiology and measurement -- Bile-acid induction of apoptosis in relation to gastrointestinal cancer -- The genotoxicity of bile acids -- Bile acids and colorectal cancer -- Bile acids and oesophageal adenocarcinoma (OA) -- Bile acids and obesity -- The role of bile acids in cholesterol-rich gallstone formation
Control code
319518576
Dimensions
unknown
Extent
1 online resource (xi, 163 pages)
Form of item
online
Isbn
9781847558336
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
t2871
Specific material designation
remote
System control number
(OCoLC)319518576

Library Locations

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      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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