Coverart for item
The Resource BioWatch PCR assays : building confidence, ensuring reliability, Committee on PCR Standards for the BioWatch Program, Board of Life Sciences, Division on Earth and Life Studies, Board on Health Sciences Policy, Institute of Medicine, National Research Council and Institute of Medicine of the National Academies

BioWatch PCR assays : building confidence, ensuring reliability, Committee on PCR Standards for the BioWatch Program, Board of Life Sciences, Division on Earth and Life Studies, Board on Health Sciences Policy, Institute of Medicine, National Research Council and Institute of Medicine of the National Academies

Label
BioWatch PCR assays : building confidence, ensuring reliability
Title
BioWatch PCR assays
Title remainder
building confidence, ensuring reliability
Statement of responsibility
Committee on PCR Standards for the BioWatch Program, Board of Life Sciences, Division on Earth and Life Studies, Board on Health Sciences Policy, Institute of Medicine, National Research Council and Institute of Medicine of the National Academies
Title variation
Polymerase chain reaction assays
Contributor
Issuing body
Sponsoring body
Subject
Genre
Language
eng
Summary
"BioWatch is an air monitoring system deployed in jurisdictions around the country with the goal of detecting the presence of certain high risk pathogenic microorganisms. It relies on a network of federal and nonfederal collaborative relationships to be successful, and is one part of a larger array of disease surveillance, intelligence-gathering, and biomonitoring activities in support of public safety and health. The assays used in the BioWatch system to detect the presence of pathogens in collected samples rely on the technique of polymerase chain reaction (PCR) to sensitively and specifically amplify target nucleic acid sequences. BioWatch PCR Assays evaluates and provides guidance on appropriate standards for the validation and verification of PCR tests and assays in order to ensure that adequate performance data are available to public health and other key decision makers with a sufficient confidence level to facilitate the public health response to a BioWatch Actionable Response. This report discusses principles of performance standards, reviews information from several existing guidance documents and standards that might be applicable to BioWatch, and discusses assay testing efforts that have occurred or are ongoing. BioWatch PCR Assays provides recommendations on general principles and approaches for a performance standard and validation framework to meet BioWatch's mission. The report also considers how developments in technology, particularly in multiplex PCR and next-generation sequencing, can contribute to the ability of the BioWatch program to meet current and future challenges. This report has been determined to contain information exempt from disclosure under 5 U.S.C. 552(b). Section 15 of the Federal Advisory Committee Act provides that the National Academies shall make its final report available to the public unless the National Academies determines that the report would disclose matters described in one or more of the exemption provisions under the Freedom of Information Act (FOIA). In such case, the National Academies "shall make public an abbreviated version of the report that does not disclose those matters." This unrestricted, abbreviated version of the report represents, in so far as possible, the committee's findings, recommendations, and other substantive material without disclosing materials described in 5 U.S.C. 552(b)."--Publisher's description
Member of
Cataloging source
N$T
Dewey number
363.32530973
Funding information
Sponsored by the U.S. Department of Homeland Security
Illustrations
illustrations
Index
no index present
LC call number
HV6433.35
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
WA 295
http://library.link/vocab/relatedWorkOrContributorName
  • National Research Council (U.S.)
  • Institute of Medicine (U.S.)
  • United States
http://library.link/vocab/subjectName
  • BioWatch Program (U.S.)
  • United States
  • Bioterrorism
  • Polymerase chain reaction
  • Pathogenic microorganisms
  • United States
  • BioWatch Program (U.S.)
  • Bioterrorism
  • Polymerase Chain Reaction
  • Biohazard Release
  • Microbiological Phenomena
  • Biological Warfare Agents
  • United States
  • BioWatch Program (U.S.)
  • United States
  • POLITICAL SCIENCE
  • Bioterrorism
  • Pathogenic microorganisms
  • Polymerase chain reaction
  • United States
Label
BioWatch PCR assays : building confidence, ensuring reliability, Committee on PCR Standards for the BioWatch Program, Board of Life Sciences, Division on Earth and Life Studies, Board on Health Sciences Policy, Institute of Medicine, National Research Council and Institute of Medicine of the National Academies
Instantiates
Publication
Copyright
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Performance Standards Provide Confidence in Results -- Key Components of a Performance Standard for BioWatch -- The Framework that Surrounds the PCR Reaction Affects Performance -- Looking to the Future: Multiplex PCR and Next Generation Sequencing -- Conclusions and Recommendations -- Appendix A: BioWatch Program and Operational Details -- Appendix B: Study Activities -- Appendix C: Glossary -- Appendix D: Biographies of Committee Members
Control code
914165948
Dimensions
unknown
Edition
Abbreviated version.
Extent
1 online resource (1 PDF file (xxiv, 175 pages))
Form of item
online
Isbn
9780309367257
Lccn
2016462657
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)914165948
Label
BioWatch PCR assays : building confidence, ensuring reliability, Committee on PCR Standards for the BioWatch Program, Board of Life Sciences, Division on Earth and Life Studies, Board on Health Sciences Policy, Institute of Medicine, National Research Council and Institute of Medicine of the National Academies
Publication
Copyright
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Performance Standards Provide Confidence in Results -- Key Components of a Performance Standard for BioWatch -- The Framework that Surrounds the PCR Reaction Affects Performance -- Looking to the Future: Multiplex PCR and Next Generation Sequencing -- Conclusions and Recommendations -- Appendix A: BioWatch Program and Operational Details -- Appendix B: Study Activities -- Appendix C: Glossary -- Appendix D: Biographies of Committee Members
Control code
914165948
Dimensions
unknown
Edition
Abbreviated version.
Extent
1 online resource (1 PDF file (xxiv, 175 pages))
Form of item
online
Isbn
9780309367257
Lccn
2016462657
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)914165948

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