Coverart for item
The Resource Caspases : roles and significance in cell death and disease, Jeffrey Warren, editor

Caspases : roles and significance in cell death and disease, Jeffrey Warren, editor

Label
Caspases : roles and significance in cell death and disease
Title
Caspases
Title remainder
roles and significance in cell death and disease
Statement of responsibility
Jeffrey Warren, editor
Contributor
Editor
Subject
Language
eng
Cataloging source
DLC
Dewey number
571.9/36
Illustrations
illustrations
Index
index present
LC call number
QH671
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Warren, Jeffrey S.
Series statement
Cell biology research progress
http://library.link/vocab/subjectName
  • Apoptosis
  • Cell death
  • SCIENCE / Life Sciences / Anatomy & Physiology
  • Apoptosis
  • Cell death
Label
Caspases : roles and significance in cell death and disease, Jeffrey Warren, editor
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Preface; Chapter 1; Caspases: A Driver in Programmed Cell Death; Abstract; 1. Introduction; 2. History of Caspases; 3. Role of Caspases in Apoptosis; 4. Initiator Caspases; 5. Executioner Caspases; 6. Apoptosis Pathways; 6.1. The Extrinsic Route of Apoptosis; 6.1.1. Death Receptor (DR) Pathway of Apoptosis; 6.1.2. Ligand Death Receptor; 6.2. The Intrinsic Route of Apoptosis; 7. Types of Caspase; 7.1. Caspase-1; 7.2. Caspase-2; 7.3. Caspase-3; 7.4. Caspase-6; 7.5. Caspase-7; 7.6. Caspase-8; 7.7. Caspase-9; 7.8. Caspase-10; 7.9. Caspase-12; 7.10. Caspase-14
  • 8. Comparison of Caspase-1, -4, -59. Cellular Proliferation; 9.1. Cellular Differentiation; 9.2. Apoptosis and Immuno-Suppression; 10. General Caspase Inhibition In Vivo; 11. Caspases in Sub-Cellular Compartments; Conclusion and Future Perspectives; References; Chapter 2; Caspases Importance in Cell Death and Disease; Abstract; 1. Introduction; 2. Apoptosis; 3. Necrosis; 4. Caspases Structure; 5. Apoptotic Role; 6. Non Apoptotic Role; 7. Immune Function; 8. An Inflammatory Microenvironment; 9. Mechanisms of Substrate Recognition; 10. Human Caspases; 11. Activity of Caspases in Inflammation
  • 12. Function of Pattern-Recognition Receptors13. Caspases in Proliferation; 14. Cell Migration; 15. Cell Differentiation; 16. Dimerisation; 17. Cleavage; 18. Caspases in Human Disease; 18.1. Cancer; 18.2. Inflammatory Diseases; 18.3. Gout; 18.4. Cryopyrin-Associated Periodic Syndromes; 18.5. Type 2 Diabetes; 18.6. Familial Mediterranean Fever; 18.7. Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne Syndrome; 18.8. Hyperimmunoglobulinemia D with Periodic Fever Syndrome; 18.9. Trypanosoma Cruzi Infection; Conclusion and Future Perspectives; References; Chapter 3
  • The Role of Executioner Caspases in Cancer Formation and MaintenanceAbstract; 1. Introduction; 2. Caspase Family; 2.1. Structural Considerations of Human Executioner Caspases; 2.2. Caspase Substrates; 2.3. Caspase Active Sites; 2.4. Caspase Exosites; 2.5. Caspase Dimerization; 2.6. Executioner Caspase Activation by Proteolysis; 2.7. Caspase Allosteric Sites; 2.8. Post-Translational Modification; 2.8.1. Ubiquitylation; 2.8.2. Phosphorylation; 2.8.3. Nitrosylation; 2.8.4. Acetylation; 2.9. Cellular Localization; 3. Caspase Gene Expression; 3.1. Splice Variants of Executioner Caspases
  • 4. Caspase Deficiencies in Cancer4.1. Expression of Caspase Inhibitory Pathways -- Upstream (MOMP) and Downstream (IAPs); 5. Mammalian Models Interrogating Pathophysiological Roles of Executioner Caspases; Conclusion; References; Supplementary Resources; Biographical Sketch; Chapter 4; The Unknown Caspase: The Role of Caspase-14 in Cell Death and Disease; Abstract; Introduction; Caspase-14: Discovery and Structure; The Role of Caspase-14 in Cell Death; The Role of Caspase-14 in Disease; Caspase-14 Protects Against Common Skin Conditions; Caspase-14 Is Implicated in Disorders of the Eye
Control code
959373869
Extent
1 online resource.
Form of item
online
Isbn
9781536102604
Lccn
2016044447
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)959373869
Label
Caspases : roles and significance in cell death and disease, Jeffrey Warren, editor
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Preface; Chapter 1; Caspases: A Driver in Programmed Cell Death; Abstract; 1. Introduction; 2. History of Caspases; 3. Role of Caspases in Apoptosis; 4. Initiator Caspases; 5. Executioner Caspases; 6. Apoptosis Pathways; 6.1. The Extrinsic Route of Apoptosis; 6.1.1. Death Receptor (DR) Pathway of Apoptosis; 6.1.2. Ligand Death Receptor; 6.2. The Intrinsic Route of Apoptosis; 7. Types of Caspase; 7.1. Caspase-1; 7.2. Caspase-2; 7.3. Caspase-3; 7.4. Caspase-6; 7.5. Caspase-7; 7.6. Caspase-8; 7.7. Caspase-9; 7.8. Caspase-10; 7.9. Caspase-12; 7.10. Caspase-14
  • 8. Comparison of Caspase-1, -4, -59. Cellular Proliferation; 9.1. Cellular Differentiation; 9.2. Apoptosis and Immuno-Suppression; 10. General Caspase Inhibition In Vivo; 11. Caspases in Sub-Cellular Compartments; Conclusion and Future Perspectives; References; Chapter 2; Caspases Importance in Cell Death and Disease; Abstract; 1. Introduction; 2. Apoptosis; 3. Necrosis; 4. Caspases Structure; 5. Apoptotic Role; 6. Non Apoptotic Role; 7. Immune Function; 8. An Inflammatory Microenvironment; 9. Mechanisms of Substrate Recognition; 10. Human Caspases; 11. Activity of Caspases in Inflammation
  • 12. Function of Pattern-Recognition Receptors13. Caspases in Proliferation; 14. Cell Migration; 15. Cell Differentiation; 16. Dimerisation; 17. Cleavage; 18. Caspases in Human Disease; 18.1. Cancer; 18.2. Inflammatory Diseases; 18.3. Gout; 18.4. Cryopyrin-Associated Periodic Syndromes; 18.5. Type 2 Diabetes; 18.6. Familial Mediterranean Fever; 18.7. Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne Syndrome; 18.8. Hyperimmunoglobulinemia D with Periodic Fever Syndrome; 18.9. Trypanosoma Cruzi Infection; Conclusion and Future Perspectives; References; Chapter 3
  • The Role of Executioner Caspases in Cancer Formation and MaintenanceAbstract; 1. Introduction; 2. Caspase Family; 2.1. Structural Considerations of Human Executioner Caspases; 2.2. Caspase Substrates; 2.3. Caspase Active Sites; 2.4. Caspase Exosites; 2.5. Caspase Dimerization; 2.6. Executioner Caspase Activation by Proteolysis; 2.7. Caspase Allosteric Sites; 2.8. Post-Translational Modification; 2.8.1. Ubiquitylation; 2.8.2. Phosphorylation; 2.8.3. Nitrosylation; 2.8.4. Acetylation; 2.9. Cellular Localization; 3. Caspase Gene Expression; 3.1. Splice Variants of Executioner Caspases
  • 4. Caspase Deficiencies in Cancer4.1. Expression of Caspase Inhibitory Pathways -- Upstream (MOMP) and Downstream (IAPs); 5. Mammalian Models Interrogating Pathophysiological Roles of Executioner Caspases; Conclusion; References; Supplementary Resources; Biographical Sketch; Chapter 4; The Unknown Caspase: The Role of Caspase-14 in Cell Death and Disease; Abstract; Introduction; Caspase-14: Discovery and Structure; The Role of Caspase-14 in Cell Death; The Role of Caspase-14 in Disease; Caspase-14 Protects Against Common Skin Conditions; Caspase-14 Is Implicated in Disorders of the Eye
Control code
959373869
Extent
1 online resource.
Form of item
online
Isbn
9781536102604
Lccn
2016044447
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)959373869

Library Locations

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      38.710138 -90.311107
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