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The Resource Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities, by Jinghua Liu, (electronic resource)

Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities, by Jinghua Liu, (electronic resource)

Creator
Contributor
Summary
Discovery of new ways to modulate estrogen actions through estrogen receptor is always exciting because of the importance of estrogen and ERs in many human diseases. In this dissertation, we report our discovery of the cross-talk between SF-hERRb and hERs and the mechanism of this cross-talk. We found that SF-hERR[beta] is able to repress the transcriptional activities of hER[alpha] and hER[beta] in various cell lines. This inhibitory effect of SF-hERR[beta] is not through alterations of estradiol binding to hERs. SF-hERRb does not inhibit hERs through direct Estrogen Response Element (ERE) competition. SF-hERR[beta] induces no alterations in hERs protein concentrations. SF-hERR[beta] inhibition of hERs is not through competition/sequestration for PGC-1[alpha], though PGC-1[alpha] can be involved. The A/B domain of hERa and the A/B and D domains of SF-hERR[beta] are required for this inhibition. We determined that SF-hERR[beta] forms complexes with hER[alpha]/hER[beta]. In addition, DY131, a hERR[beta]/hERR[gamma] specific agonist can inhibit hER and SF-hERR[beta] positive human breast cancer MCF-7 cell growth. These findings provide us novel approaches to regulate hERs activities which may lead to discovery of new therapeutic targets for ER-dependent diseases
Language
eng
Work
Publication
Extent
1 online resource (xi, 137 pages)
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on September 10, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Dennis B. Lubahn
  • Vita
Instance
Label
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities
Title
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities
Statement of responsibility
by Jinghua Liu
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Discovery of new ways to modulate estrogen actions through estrogen receptor is always exciting because of the importance of estrogen and ERs in many human diseases. In this dissertation, we report our discovery of the cross-talk between SF-hERRb and hERs and the mechanism of this cross-talk. We found that SF-hERR[beta] is able to repress the transcriptional activities of hER[alpha] and hER[beta] in various cell lines. This inhibitory effect of SF-hERR[beta] is not through alterations of estradiol binding to hERs. SF-hERRb does not inhibit hERs through direct Estrogen Response Element (ERE) competition. SF-hERR[beta] induces no alterations in hERs protein concentrations. SF-hERR[beta] inhibition of hERs is not through competition/sequestration for PGC-1[alpha], though PGC-1[alpha] can be involved. The A/B domain of hERa and the A/B and D domains of SF-hERR[beta] are required for this inhibition. We determined that SF-hERR[beta] forms complexes with hER[alpha]/hER[beta]. In addition, DY131, a hERR[beta]/hERR[gamma] specific agonist can inhibit hER and SF-hERR[beta] positive human breast cancer MCF-7 cell growth. These findings provide us novel approaches to regulate hERs activities which may lead to discovery of new therapeutic targets for ER-dependent diseases
Cataloging source
MUU
http://library.link/vocab/creatorDate
1978-
http://library.link/vocab/creatorName
Liu, Jinghua
Degree
Ph. D.
Dissertation year
2009.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1954-
http://library.link/vocab/relatedWorkOrContributorName
Lubahn, Dennis B.
http://library.link/vocab/subjectName
  • Estrogen
  • Estrogen
  • Breast
  • Diseases
  • Transgenic mice
  • Peroxisomes
  • Estradiol
  • Bisphenol A
Target audience
specialized
Label
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities, by Jinghua Liu, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on September 10, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Dennis B. Lubahn
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
695044270
Extent
1 online resource (xi, 137 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)695044270
Label
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities, by Jinghua Liu, (electronic resource)
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on September 10, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Dennis B. Lubahn
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
695044270
Extent
1 online resource (xi, 137 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)695044270

Subject

Genre

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