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The Resource Clinical ethics at the crossroads of genetic and reproductive technologies, edited by Sorin Hostiuc

Clinical ethics at the crossroads of genetic and reproductive technologies, edited by Sorin Hostiuc

Label
Clinical ethics at the crossroads of genetic and reproductive technologies
Title
Clinical ethics at the crossroads of genetic and reproductive technologies
Statement of responsibility
edited by Sorin Hostiuc
Contributor
Editor
Subject
Language
eng
Cataloging source
YDX
Dewey number
174.2/96042
Illustrations
illustrations
Index
index present
LC call number
QH438.7
LC item number
.C55 2018
Literary form
non fiction
Nature of contents
bibliography
NLM call number
  • 2019 A-217
  • WQ 208
http://library.link/vocab/relatedWorkOrContributorName
Hostiuc, Sorin
http://library.link/vocab/subjectName
  • Human genetics
  • Genetic engineering
  • Human reproductive technology
  • Medical ethics
  • Medical innovations
  • Reproductive Techniques
  • Ethics, Clinical
  • Human Genetics
  • Genetic engineering
  • Human genetics
  • Human reproductive technology
  • Medical ethics
  • Medical innovations
Label
Clinical ethics at the crossroads of genetic and reproductive technologies, edited by Sorin Hostiuc
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Genomic editing--from human health to the "perfect child" / Daniela Iancu -- Introduction -- Definitions and context -- Recombinant DNA technology--the basis for DNA modification -- Genome editing -- Zinc finger nucleases (ZFNs) -- CRISPR/Cas9 technology -- Base editing technology -- Principles of using genome editing in research and clinical practice -- Ethical issues in clinical genome editing -- Nonmaleficence and risk/benefit assessment -- Beneficence in gene-editing therapies -- Respect for autonomy -- Confidentiality -- Applying the principle of justice in clinical genome editing -- Eugenics, enhancement, and "designer babies" -- Conclusions -- References -- Further reading -- 2. Ethics of mitochondrial gene replacement therapy / Rebecca Dimond -- Introduction -- What is mitochondrial disease and mitochondrial donation? -- The UK timeline -- The international position -- Are the techniques safe? -- Ethical issues -- "Three-parent babies" and identity -- Genetic modification and the "slippery slope" -- Donating eggs (risls and benefits) -- Difference between PNT and MST -- Mitochondrial disease as complex : diagnosis, predicting risk, and genetic counseling -- Alternative reproductive options -- Polar body transfer and gene editing -- Conclusion -- References -- Further reading -- 3. Reproductive technologies used by same gender couples / Diana Badiu and Valentina Nastasel -- Introduction -- Procreative autonomy -- Gamete and embryo donation -- Surrogacy agreement -- Transgender parenthood -- Conscience clause -- Conclusions -- References -- Further reading -- 4. Ethical issues raised by multiparents / Maria Aluas -- Introduction -- Key terms in the debate : filiation, kinship, and parenthood -- Multiparents of children born through ARTs -- Maternity -- Paternity -- Where do all these parents come from? -- Sperm donation -- Egg donation -- Embryo donation -- Surrogacy -- Ethical issues -- The right to know one's origins -- Donors' anonymity -- The consent of participants -- Secondary ethical issues -- Medical tourism -- Slippery slope -- Final considerations -- References -- Further reading -- 5. Revisiting the nondirective principle of genetic counseling in prenatal screening / Sandrine de Montgolfier -- Introduction -- Historical background and implementation of public policy for prenatal screening -- Ethical references in the development of screening tests -- Genetic consultation in prenatal screening : nondirective and neutral? -- Nondirective consultation challenged or an opportunity to support reproductive autonomy by complete balanced information? -- Taking reproductive autonomy further : innovations in information and aided decision-making tools -- Conclusion -- References -- 6. Sex selection, gender selection, and sexism / Iva Rinčić, Amir Muzur and Stephen O. Sodeke -- Introduction -- The roots and reasons of sex selection -- From politics on reproduction to biopolicy -- Missing girls : why and how many? -- Legal and ethical questions -- Conclusion -- References -- Further reading -- 7. The impact of big data on beginning of life issues / Dario Sacchini and Antonio G. Spagnolo -- Introduction : first of all, what is really "big data"? -- Big data and health care : an expanding universe -- Big data and beginning-of-life issues : a field in its infancy -- Conclusion : a work in progress -- References -- Further reading -- 8. The moral status of the embryo from the standpoint of social perceptions / Rafael Pardo -- Introduction -- The empirical perspective in bioethics and public perceptions of science studies -- The notion of moral status -- Two contrasting narratives on the moral status of the embryo -- The status of the embryo fram and the beginning of individual human life -- Views on the status of the embryo, religious beliefs, scientific literacy, and gender -- Moral status and attitudes to embryo research -- Conclusions -- References -- 9. Fetal reduction / Ana S. Carvalho, Margarida Silvestre, Susana Magalhães and Joana Araújo -- Bioethical issues of fetal reduction : why words matter -- Medical use : selective fetal reduction -- Medical use : non selective fetal reduction -- Nonmedical uses : selective fetal reduction -- Nonmedical use : nonselective fetal reduction -- The moral status of embryo and fetus -- Fetal reduction : "a soft cover for hard choices" -- Parental autonomy and parental responsbility -- Conclusion -- References
  • 10. Stem cell therapies for neurodegenerative disorders : an ethical analysis / Sorin Hostiuc, Ionut Negoi, Mugurel Constantin Rusu and Mihaela Hostiuc -- Introduction -- An overview on stem cell therapies for neurodegenerative disorders -- Parkinson's Disease -- Stem cell treatments for other neurological disorders -- Use of placebo controls in sham surgery -- Is sham surgery accepted by potential subjects? -- Sham surgery as a form of mitigated trolley -- Risk to benefit analysis -- What role should collateral benefits have in the decision to allow sham surgery? -- Are placebo-controlled trials actually needed in surgery studies? -- Autonomy versus therapeutic misconception -- Risk to benefit analysis for stem cell therapies in neurodegenerative disorders -- What are the potential benefits of stem cell therapy in neurodegenerative disorder -- Induced pluripotent stem cell therapies for neurodegenerative disorders -- Moral status of IPSCs -- Conclusions -- References -- Further reading -- 11. Predictive genetic testing in multifactorial disorders / Sorin Hostiuc -- Introduction -- Information and consent in predictive testing for multifactorial disorders -- Respect for autonomy -- Delivering relevant information -- Understanding relevant information -- Capacity to act voluntarily -- Nondirectiveness in predictive testing for multifactorial disorders -- Direct to consumer genetic testing -- When to recommend predictive genetic testing? -- Nonmaleficence and risk assessment -- Confidentiality and family sharing of the genetic results -- Predictive genetic testing in children -- Genetic exceptionalism and multifactorial disorders -- Conclusions -- References -- Further reading -- 12. Whole-genome sequencing as a method of prenatal genetic diagnosis / Fermín J. González-Melado -- Introduction -- From the standard of prenatal diagnosis to whole-genome sequencing -- Whole-genome sequencing as a prenatal diagnostic tool -- What is whole-genome sequencing? -- Whole-genome sequencing applications in prenatal diagnosis -- Limitations of whole-genome sequencing -- Ethical problems surrounding whole-genome sequencing -- Large amounts of information -- Anxiety and confusion in parents -- Parents' reproductive choices, expectations, and genetic determinism -- Right of the parents to information vs. right of the child to "not to know" -- The importance of pre-WGS test and post-WGS diagnostic counseling -- Counseling in WGS -- Pre-WGS test counseling -- Post-WGS diagnostic counseling -- Ethical reflection on WGS test in prenatal diagnosis -- Conclusion -- References -- 13. Noninvasive prenatal genetic diagnosis / Sorin Hostiuc -- Introduction -- High-risk versus low-risk populations -- Consent and decision-sharing -- Counseling for NIPT -- Should parents be allowed to get tested "for information only"? -- A teleological approach to NIPT -- NIPT and discrimination -- Eugenics, procreative beneficence, and NIPT -- Conclusions -- References -- 14. Prenatal testing in low-risk populations : a US perspective / Jazmine L. Gabriel and Lauren Diskin -- Introduction -- Background on offering the test to low-risk women -- Overestimation of the significance of genetic information -- Diagnostic test versus screening test -- Reduced penetrance and variable expressivity -- Negative test and health baby assumptions -- Incidental findings : maternal conditions -- Abortion -- Ethics of testing just for information -- Practical issues : who will counsel patients? -- OB/Gyn counseling -- Information access outside of the United States -- Problematic solutions -- Linear model of information transmission -- Justice issues : access to testing -- Conclusion -- References -- Further reading -- 15. Using genetics for enhancement (liberal eugenics) / Sonja Pavlovic, Milena Ugrin, Stefan Micic, Vladimir Gasic, Jelena Dimitrijevic and Ursela Barteczko -- Introduction -- Definition of enhancement -- Types of enhancement -- (How) should we distinguish enhancement from therapy? -- Genetic enhancement -- Genomics and epigenomics as base for genetic enhancement -- High-throughput methodology for genome wide genetic, epigenetic, and gene expression profiling -- Personalized medicine as a model for the implementation of genetic enhancement -- From predictive genomics to preventive medicine and genetic enhancement -- Ethical issues in personalized medicine -- Gene therapy, molecular-targeted therapy, and cellular therapy -- Ethical aspects of gene therapy, molecular-targeted therapy, and cellular therapy -- Gene enhancement, molecular-targeted enhancement, cellular enhancement -- Liberal eugenics -- Regulation, health coverage, and public opinion -- Conclusion -- Acknowledgement -- References -- 16. Should incidental findings arising from prenatal testing be reported indiscriminately to patients? / Valentina Kaneva and Ina Dimitrova -- Introduction -- Incidental findings in the prenatal setting -- Challenges of definition -- Current practice, new developments, and specific features of the prenatal setting -- Reporting incidental findings in the prenatal setting -- Arguments pro disclosure -- Arguments against disclosure -- Handling incidental findings : informed consent procedures and pretest counseling in genetic testing -- Conclusion -- References -- Further reading -- 17. Third party sharing of genetic information / Maureen Durnin and Michael Hoy -- Introduction -- Medical practitioners and institutions -- Family members, partners, and potential partners as third party -- Criminal investigations -- Employment -- Pharmaceutical investigations and clinical research -- Insurance -- Conclusions -- References -- Further reading
Control code
1023527433
Dimensions
23 cm
Extent
xiv, 417 pages
Isbn
9780128137642
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
(OCoLC)1023527433
Label
Clinical ethics at the crossroads of genetic and reproductive technologies, edited by Sorin Hostiuc
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Genomic editing--from human health to the "perfect child" / Daniela Iancu -- Introduction -- Definitions and context -- Recombinant DNA technology--the basis for DNA modification -- Genome editing -- Zinc finger nucleases (ZFNs) -- CRISPR/Cas9 technology -- Base editing technology -- Principles of using genome editing in research and clinical practice -- Ethical issues in clinical genome editing -- Nonmaleficence and risk/benefit assessment -- Beneficence in gene-editing therapies -- Respect for autonomy -- Confidentiality -- Applying the principle of justice in clinical genome editing -- Eugenics, enhancement, and "designer babies" -- Conclusions -- References -- Further reading -- 2. Ethics of mitochondrial gene replacement therapy / Rebecca Dimond -- Introduction -- What is mitochondrial disease and mitochondrial donation? -- The UK timeline -- The international position -- Are the techniques safe? -- Ethical issues -- "Three-parent babies" and identity -- Genetic modification and the "slippery slope" -- Donating eggs (risls and benefits) -- Difference between PNT and MST -- Mitochondrial disease as complex : diagnosis, predicting risk, and genetic counseling -- Alternative reproductive options -- Polar body transfer and gene editing -- Conclusion -- References -- Further reading -- 3. Reproductive technologies used by same gender couples / Diana Badiu and Valentina Nastasel -- Introduction -- Procreative autonomy -- Gamete and embryo donation -- Surrogacy agreement -- Transgender parenthood -- Conscience clause -- Conclusions -- References -- Further reading -- 4. Ethical issues raised by multiparents / Maria Aluas -- Introduction -- Key terms in the debate : filiation, kinship, and parenthood -- Multiparents of children born through ARTs -- Maternity -- Paternity -- Where do all these parents come from? -- Sperm donation -- Egg donation -- Embryo donation -- Surrogacy -- Ethical issues -- The right to know one's origins -- Donors' anonymity -- The consent of participants -- Secondary ethical issues -- Medical tourism -- Slippery slope -- Final considerations -- References -- Further reading -- 5. Revisiting the nondirective principle of genetic counseling in prenatal screening / Sandrine de Montgolfier -- Introduction -- Historical background and implementation of public policy for prenatal screening -- Ethical references in the development of screening tests -- Genetic consultation in prenatal screening : nondirective and neutral? -- Nondirective consultation challenged or an opportunity to support reproductive autonomy by complete balanced information? -- Taking reproductive autonomy further : innovations in information and aided decision-making tools -- Conclusion -- References -- 6. Sex selection, gender selection, and sexism / Iva Rinčić, Amir Muzur and Stephen O. Sodeke -- Introduction -- The roots and reasons of sex selection -- From politics on reproduction to biopolicy -- Missing girls : why and how many? -- Legal and ethical questions -- Conclusion -- References -- Further reading -- 7. The impact of big data on beginning of life issues / Dario Sacchini and Antonio G. Spagnolo -- Introduction : first of all, what is really "big data"? -- Big data and health care : an expanding universe -- Big data and beginning-of-life issues : a field in its infancy -- Conclusion : a work in progress -- References -- Further reading -- 8. The moral status of the embryo from the standpoint of social perceptions / Rafael Pardo -- Introduction -- The empirical perspective in bioethics and public perceptions of science studies -- The notion of moral status -- Two contrasting narratives on the moral status of the embryo -- The status of the embryo fram and the beginning of individual human life -- Views on the status of the embryo, religious beliefs, scientific literacy, and gender -- Moral status and attitudes to embryo research -- Conclusions -- References -- 9. Fetal reduction / Ana S. Carvalho, Margarida Silvestre, Susana Magalhães and Joana Araújo -- Bioethical issues of fetal reduction : why words matter -- Medical use : selective fetal reduction -- Medical use : non selective fetal reduction -- Nonmedical uses : selective fetal reduction -- Nonmedical use : nonselective fetal reduction -- The moral status of embryo and fetus -- Fetal reduction : "a soft cover for hard choices" -- Parental autonomy and parental responsbility -- Conclusion -- References
  • 10. Stem cell therapies for neurodegenerative disorders : an ethical analysis / Sorin Hostiuc, Ionut Negoi, Mugurel Constantin Rusu and Mihaela Hostiuc -- Introduction -- An overview on stem cell therapies for neurodegenerative disorders -- Parkinson's Disease -- Stem cell treatments for other neurological disorders -- Use of placebo controls in sham surgery -- Is sham surgery accepted by potential subjects? -- Sham surgery as a form of mitigated trolley -- Risk to benefit analysis -- What role should collateral benefits have in the decision to allow sham surgery? -- Are placebo-controlled trials actually needed in surgery studies? -- Autonomy versus therapeutic misconception -- Risk to benefit analysis for stem cell therapies in neurodegenerative disorders -- What are the potential benefits of stem cell therapy in neurodegenerative disorder -- Induced pluripotent stem cell therapies for neurodegenerative disorders -- Moral status of IPSCs -- Conclusions -- References -- Further reading -- 11. Predictive genetic testing in multifactorial disorders / Sorin Hostiuc -- Introduction -- Information and consent in predictive testing for multifactorial disorders -- Respect for autonomy -- Delivering relevant information -- Understanding relevant information -- Capacity to act voluntarily -- Nondirectiveness in predictive testing for multifactorial disorders -- Direct to consumer genetic testing -- When to recommend predictive genetic testing? -- Nonmaleficence and risk assessment -- Confidentiality and family sharing of the genetic results -- Predictive genetic testing in children -- Genetic exceptionalism and multifactorial disorders -- Conclusions -- References -- Further reading -- 12. Whole-genome sequencing as a method of prenatal genetic diagnosis / Fermín J. González-Melado -- Introduction -- From the standard of prenatal diagnosis to whole-genome sequencing -- Whole-genome sequencing as a prenatal diagnostic tool -- What is whole-genome sequencing? -- Whole-genome sequencing applications in prenatal diagnosis -- Limitations of whole-genome sequencing -- Ethical problems surrounding whole-genome sequencing -- Large amounts of information -- Anxiety and confusion in parents -- Parents' reproductive choices, expectations, and genetic determinism -- Right of the parents to information vs. right of the child to "not to know" -- The importance of pre-WGS test and post-WGS diagnostic counseling -- Counseling in WGS -- Pre-WGS test counseling -- Post-WGS diagnostic counseling -- Ethical reflection on WGS test in prenatal diagnosis -- Conclusion -- References -- 13. Noninvasive prenatal genetic diagnosis / Sorin Hostiuc -- Introduction -- High-risk versus low-risk populations -- Consent and decision-sharing -- Counseling for NIPT -- Should parents be allowed to get tested "for information only"? -- A teleological approach to NIPT -- NIPT and discrimination -- Eugenics, procreative beneficence, and NIPT -- Conclusions -- References -- 14. Prenatal testing in low-risk populations : a US perspective / Jazmine L. Gabriel and Lauren Diskin -- Introduction -- Background on offering the test to low-risk women -- Overestimation of the significance of genetic information -- Diagnostic test versus screening test -- Reduced penetrance and variable expressivity -- Negative test and health baby assumptions -- Incidental findings : maternal conditions -- Abortion -- Ethics of testing just for information -- Practical issues : who will counsel patients? -- OB/Gyn counseling -- Information access outside of the United States -- Problematic solutions -- Linear model of information transmission -- Justice issues : access to testing -- Conclusion -- References -- Further reading -- 15. Using genetics for enhancement (liberal eugenics) / Sonja Pavlovic, Milena Ugrin, Stefan Micic, Vladimir Gasic, Jelena Dimitrijevic and Ursela Barteczko -- Introduction -- Definition of enhancement -- Types of enhancement -- (How) should we distinguish enhancement from therapy? -- Genetic enhancement -- Genomics and epigenomics as base for genetic enhancement -- High-throughput methodology for genome wide genetic, epigenetic, and gene expression profiling -- Personalized medicine as a model for the implementation of genetic enhancement -- From predictive genomics to preventive medicine and genetic enhancement -- Ethical issues in personalized medicine -- Gene therapy, molecular-targeted therapy, and cellular therapy -- Ethical aspects of gene therapy, molecular-targeted therapy, and cellular therapy -- Gene enhancement, molecular-targeted enhancement, cellular enhancement -- Liberal eugenics -- Regulation, health coverage, and public opinion -- Conclusion -- Acknowledgement -- References -- 16. Should incidental findings arising from prenatal testing be reported indiscriminately to patients? / Valentina Kaneva and Ina Dimitrova -- Introduction -- Incidental findings in the prenatal setting -- Challenges of definition -- Current practice, new developments, and specific features of the prenatal setting -- Reporting incidental findings in the prenatal setting -- Arguments pro disclosure -- Arguments against disclosure -- Handling incidental findings : informed consent procedures and pretest counseling in genetic testing -- Conclusion -- References -- Further reading -- 17. Third party sharing of genetic information / Maureen Durnin and Michael Hoy -- Introduction -- Medical practitioners and institutions -- Family members, partners, and potential partners as third party -- Criminal investigations -- Employment -- Pharmaceutical investigations and clinical research -- Insurance -- Conclusions -- References -- Further reading
Control code
1023527433
Dimensions
23 cm
Extent
xiv, 417 pages
Isbn
9780128137642
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
(OCoLC)1023527433

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      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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