The Resource Combination therapy versus intensification of statin monotherapy : an update, prepared for Agency for Healthcare Research and Quality ; prepared by Johns Hopkins University Evidence-based Practice Center ; investigators, Anne K. Monroe, M.D., M.S.P.H., Kimberly A. Gudzune, M.D., M.P.H., Ritu Sharma, B.Sc., Yohalakshmi Chelladurai, M.B.B.S., M.P.H., Padmini D. Ranasinghe, M.D., M.P.H., Mohammed T. Ansari, M.B.B.S., M.Med.Sc., M.Phil., and Karen A. Robinson, Ph.D

Combination therapy versus intensification of statin monotherapy : an update, prepared for Agency for Healthcare Research and Quality ; prepared by Johns Hopkins University Evidence-based Practice Center ; investigators, Anne K. Monroe, M.D., M.S.P.H., Kimberly A. Gudzune, M.D., M.P.H., Ritu Sharma, B.Sc., Yohalakshmi Chelladurai, M.B.B.S., M.P.H., Padmini D. Ranasinghe, M.D., M.P.H., Mohammed T. Ansari, M.B.B.S., M.Med.Sc., M.Phil., and Karen A. Robinson, Ph.D

Label
Combination therapy versus intensification of statin monotherapy : an update
Title
Combination therapy versus intensification of statin monotherapy
Title remainder
an update
Statement of responsibility
prepared for Agency for Healthcare Research and Quality ; prepared by Johns Hopkins University Evidence-based Practice Center ; investigators, Anne K. Monroe, M.D., M.S.P.H., Kimberly A. Gudzune, M.D., M.P.H., Ritu Sharma, B.Sc., Yohalakshmi Chelladurai, M.B.B.S., M.P.H., Padmini D. Ranasinghe, M.D., M.P.H., Mohammed T. Ansari, M.B.B.S., M.Med.Sc., M.Phil., and Karen A. Robinson, Ph.D
Title variation
Effective health care program
Creator
Contributor
Author
Issuing body
Subject
Genre
Language
eng
Summary
Objective: To assess the benefits and harms of combination of statin and other lipid-modifying medication compared to intensification of statin monotherapy. This is an update to a 2009 review. Data sources: The search for the prior review included MEDLINE (r) from 1966 to May 2009, Embase (r) from 1980 to May 2009, and the Cochrane Library to the third quarter of 2008. Additional searches of MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from May 2008 to July 2013 were conducted for the update. Review methods: Paired investigators independently screened search results to assess eligibility. Investigators abstracted data sequentially and assessed risk of bias independently. Investigators graded the strength of evidence (SOE) as a group. Results: All evidence for clinical outcomes (mortality, acute coronary events, and revascularization procedures) were graded as insufficient when comparing lower potency combination therapy with higher potency statin monotherapy. Conclusions: Although many studies looked at intermediate outcomes, few studies addressed the question of which approach produces better clinical outcomes. Combination of statin with ezetimibe or bile acid sequestrant lowered LDL-c better than intensification of statin monotherapy, but evidence for clinical outcomes (mortality, acute coronary events, and revascularization procedures) was insufficient across all potency comparisons for all combination therapy regimens. Additional studies evaluating long-term clinical benefits and harms are needed to better inform clinical decisionmaking, patient choice, and clinical practice guidelines
Member of
Cataloging source
MMU
http://library.link/vocab/creatorName
Monroe, Anne K
Funding information
Conducted by the Johns Hopkins University Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ)
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WB 330
http://library.link/vocab/relatedWorkOrContributorDate
active 2011
http://library.link/vocab/relatedWorkOrContributorName
  • Gudzune, Kimberly A.
  • Sharma, Ritu
  • Chelladurai, Yohalakshmi
  • Ranasinghe, Padmini D.
  • Ansari, Mohammed
  • Robinson, Karen A.
  • Sharma, M
  • United States
  • Johns Hopkins University
  • Effective Health Care Program (U.S.)
Series statement
  • Comparative effectiveness review
  • AHRQ publication
Series volume
  • number 132
  • no. 14-EHC013-EF
http://library.link/vocab/subjectName
  • Anticholesteremic Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Coronary Disease
  • Drug Evaluation
  • Drug Therapy, Combination
  • Evidence-Based Medicine
  • Hypercholesterolemia
http://bibfra.me/vocab/relation/supportingbody
  • SGEpYsXqBGk
  • RzTDSdffmEM
Label
Combination therapy versus intensification of statin monotherapy : an update, prepared for Agency for Healthcare Research and Quality ; prepared by Johns Hopkins University Evidence-based Practice Center ; investigators, Anne K. Monroe, M.D., M.S.P.H., Kimberly A. Gudzune, M.D., M.P.H., Ritu Sharma, B.Sc., Yohalakshmi Chelladurai, M.B.B.S., M.P.H., Padmini D. Ranasinghe, M.D., M.P.H., Mohammed T. Ansari, M.B.B.S., M.Med.Sc., M.Phil., and Karen A. Robinson, Ph.D
Instantiates
Publication
Note
"February 2014."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
875296261
Extent
1 online resource (394 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)875296261
Label
Combination therapy versus intensification of statin monotherapy : an update, prepared for Agency for Healthcare Research and Quality ; prepared by Johns Hopkins University Evidence-based Practice Center ; investigators, Anne K. Monroe, M.D., M.S.P.H., Kimberly A. Gudzune, M.D., M.P.H., Ritu Sharma, B.Sc., Yohalakshmi Chelladurai, M.B.B.S., M.P.H., Padmini D. Ranasinghe, M.D., M.P.H., Mohammed T. Ansari, M.B.B.S., M.Med.Sc., M.Phil., and Karen A. Robinson, Ph.D
Publication
Note
"February 2014."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
875296261
Extent
1 online resource (394 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)875296261

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