The Resource Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
Resource Information
The item Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from 1 library branch.
- Summary
- "Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date and their application to future MTDD."--
- Language
- eng
- Extent
- 1 online resource (xxvii, 365 pages)
- Contents
-
- Simple drugs do not cure complex diseases: the need for multi-targeted drugs
- Clinical need and rationale for multi-target drugs in psychiatry
- Drug molecules and biology: network and systems aspects
- Chemoinformatic approaches to target identification
- Designing multi-target drugs: in vitro panel screening, biological fingerprinting
- Phenotypic and in vivo screening: lead discovery and drug repurposing
- Target/s identification approaches: experimental biological approaches
- Historical strategies for lead generation
- In silico lead generation approaches in multi-target drug discovery
- The challenges of multi-target lead optimization
- Combination agents versus multi-targeted agents: pros and cons
- The discovery of lapatinib
- Identification and optimization of dual PI3K/mTOR inhibitors
- Discovery of HDAC-inhibiting multi-target inhibitors
- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL
- Discovery of the anti-psychotic drug, ziprasidone
- The rational design of triple reuptake inhibitors for the treatment of depression
- Discovery of multi-target agents for neurological diseases via ligand design
- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists
- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE)
- Isbn
- 9781849733625
- Label
- Designing multi-target drugs
- Title
- Designing multi-target drugs
- Statement of responsibility
- editors, J. Richard Morphy and C. John Harris
- Language
- eng
- Summary
- "Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date and their application to future MTDD."--
- Assigning source
- Provided by publisher
- Cataloging source
- UKRSC
- Dewey number
- 615.19
- Illustrations
- illustrations
- Index
- index present
- LC call number
- RS420
- LC item number
- .D47 2012eb
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
- QV 745
- http://library.link/vocab/relatedWorkOrContributorName
-
- Morphy, Richard
- Harris, C. John
- Series statement
- RSC drug discovery series
- Series volume
- 21
- http://library.link/vocab/subjectName
-
- Drugs
- Drug targeting
- Drug Design
- Polypharmacy
- Drug Delivery Systems
- Molecular Targeted Therapy
- Chemistry
- MEDICAL
- MEDICAL
- MEDICAL
- MEDICAL
- Drug targeting
- Drugs
- Label
- Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Simple drugs do not cure complex diseases: the need for multi-targeted drugs -- Clinical need and rationale for multi-target drugs in psychiatry -- Drug molecules and biology: network and systems aspects -- Chemoinformatic approaches to target identification -- Designing multi-target drugs: in vitro panel screening, biological fingerprinting -- Phenotypic and in vivo screening: lead discovery and drug repurposing -- Target/s identification approaches: experimental biological approaches -- Historical strategies for lead generation -- In silico lead generation approaches in multi-target drug discovery -- The challenges of multi-target lead optimization -- Combination agents versus multi-targeted agents: pros and cons -- The discovery of lapatinib -- Identification and optimization of dual PI3K/mTOR inhibitors -- Discovery of HDAC-inhibiting multi-target inhibitors -- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL -- Discovery of the anti-psychotic drug, ziprasidone -- The rational design of triple reuptake inhibitors for the treatment of depression -- Discovery of multi-target agents for neurological diseases via ligand design -- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists -- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE)
- Control code
- 789150271
- Extent
- 1 online resource (xxvii, 365 pages)
- Form of item
- online
- Isbn
- 9781849733625
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations
- http://library.link/vocab/ext/overdrive/overdriveId
- t3671
- Specific material designation
- remote
- System control number
- (OCoLC)789150271
- Label
- Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Simple drugs do not cure complex diseases: the need for multi-targeted drugs -- Clinical need and rationale for multi-target drugs in psychiatry -- Drug molecules and biology: network and systems aspects -- Chemoinformatic approaches to target identification -- Designing multi-target drugs: in vitro panel screening, biological fingerprinting -- Phenotypic and in vivo screening: lead discovery and drug repurposing -- Target/s identification approaches: experimental biological approaches -- Historical strategies for lead generation -- In silico lead generation approaches in multi-target drug discovery -- The challenges of multi-target lead optimization -- Combination agents versus multi-targeted agents: pros and cons -- The discovery of lapatinib -- Identification and optimization of dual PI3K/mTOR inhibitors -- Discovery of HDAC-inhibiting multi-target inhibitors -- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL -- Discovery of the anti-psychotic drug, ziprasidone -- The rational design of triple reuptake inhibitors for the treatment of depression -- Discovery of multi-target agents for neurological diseases via ligand design -- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists -- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE)
- Control code
- 789150271
- Extent
- 1 online resource (xxvii, 365 pages)
- Form of item
- online
- Isbn
- 9781849733625
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations
- http://library.link/vocab/ext/overdrive/overdriveId
- t3671
- Specific material designation
- remote
- System control number
- (OCoLC)789150271
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Designing-multi-target-drugs-editors-J.-Richard/P9Pxpw8GHIk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Designing-multi-target-drugs-editors-J.-Richard/P9Pxpw8GHIk/">Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
