Coverart for item
The Resource Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris

Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris

Label
Designing multi-target drugs
Title
Designing multi-target drugs
Statement of responsibility
editors, J. Richard Morphy and C. John Harris
Contributor
Editor
Subject
Language
eng
Summary
"Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date and their application to future MTDD."--
Member of
Assigning source
Provided by publisher
Cataloging source
UKRSC
Dewey number
615.19
Illustrations
illustrations
Index
index present
LC call number
RS420
LC item number
.D47 2012eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 745
http://library.link/vocab/relatedWorkOrContributorName
  • Morphy, Richard
  • Harris, C. John
Series statement
RSC drug discovery series
Series volume
21
http://library.link/vocab/subjectName
  • Drugs
  • Drug targeting
  • Drug Design
  • Polypharmacy
  • Drug Delivery Systems
  • Molecular Targeted Therapy
  • Chemistry
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Drug targeting
  • Drugs
Label
Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Simple drugs do not cure complex diseases: the need for multi-targeted drugs -- Clinical need and rationale for multi-target drugs in psychiatry -- Drug molecules and biology: network and systems aspects -- Chemoinformatic approaches to target identification -- Designing multi-target drugs: in vitro panel screening, biological fingerprinting -- Phenotypic and in vivo screening: lead discovery and drug repurposing -- Target/s identification approaches: experimental biological approaches -- Historical strategies for lead generation -- In silico lead generation approaches in multi-target drug discovery -- The challenges of multi-target lead optimization -- Combination agents versus multi-targeted agents: pros and cons -- The discovery of lapatinib -- Identification and optimization of dual PI3K/mTOR inhibitors -- Discovery of HDAC-inhibiting multi-target inhibitors -- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL -- Discovery of the anti-psychotic drug, ziprasidone -- The rational design of triple reuptake inhibitors for the treatment of depression -- Discovery of multi-target agents for neurological diseases via ligand design -- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists -- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE)
Control code
789150271
Extent
1 online resource (xxvii, 365 pages)
Form of item
online
Isbn
9781849733625
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
t3671
Specific material designation
remote
System control number
(OCoLC)789150271
Label
Designing multi-target drugs, editors, J. Richard Morphy and C. John Harris
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Simple drugs do not cure complex diseases: the need for multi-targeted drugs -- Clinical need and rationale for multi-target drugs in psychiatry -- Drug molecules and biology: network and systems aspects -- Chemoinformatic approaches to target identification -- Designing multi-target drugs: in vitro panel screening, biological fingerprinting -- Phenotypic and in vivo screening: lead discovery and drug repurposing -- Target/s identification approaches: experimental biological approaches -- Historical strategies for lead generation -- In silico lead generation approaches in multi-target drug discovery -- The challenges of multi-target lead optimization -- Combination agents versus multi-targeted agents: pros and cons -- The discovery of lapatinib -- Identification and optimization of dual PI3K/mTOR inhibitors -- Discovery of HDAC-inhibiting multi-target inhibitors -- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL -- Discovery of the anti-psychotic drug, ziprasidone -- The rational design of triple reuptake inhibitors for the treatment of depression -- Discovery of multi-target agents for neurological diseases via ligand design -- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists -- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE)
Control code
789150271
Extent
1 online resource (xxvii, 365 pages)
Form of item
online
Isbn
9781849733625
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
t3671
Specific material designation
remote
System control number
(OCoLC)789150271

Library Locations

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      38.710138 -90.311107
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