The Resource Development and evaluation of a novel germanium-68/gallium-68 generator, by Yu-Wen Chang, (electronic resource)

Development and evaluation of a novel germanium-68/gallium-68 generator, by Yu-Wen Chang, (electronic resource)

Label
Development and evaluation of a novel germanium-68/gallium-68 generator
Title
Development and evaluation of a novel germanium-68/gallium-68 generator
Statement of responsibility
by Yu-Wen Chang
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The aim of this research is to evaluate Fajans adsorption technique to deliver 68Ga in a high concentration, low volume with minimal impurities including 68Ge breakthrough and other metals. First carrier-free stock solutions and stock solutions containing three different concentrations of carrier were tested. Here the stock solution containing 68Ge:Ge ratio of 1:20K, 1:200K, and 1:2KK was represented as 20K, 200K and 2KK fold carrier-added stock solution respectively. The optimized concentration level of carrier was utilized for further tests at four different pH values and two different buffers. The Fajans system was evaluated with two different adsorbents and two column bed sizes. In addition, we investigated a carrier-free with acetone added stock solution. The optimized conditions were determined to be that the 200K fold carrier stock solution in NaOAc buffer at pH 5.6 is the most suitable condition for 1.0 ml BSi beads to obtain the highest 68Ga yield (90%) and the lowest 68Ge breakthrough (0.009%) in the daughter product. At pH 5.6 stock solutions, the optimized conditions for acetone added stock solution were determined to be 10% acetone at NH4OAc buffer for 1.0 ml BSi beads (92% 68Ga yield and 0.04% 68Ge breakthrough) and 50% acetone at NH4OAc buffer for 0.2 ml BSi beads (82% 68Ga yield and 0.03% 68Ge breakthrough). The addition of carrier germanium to the 68Ge/68Ga solution did help in decreasing the amount of 68Ge detected in the wash and strip solutions. The progressive lowering of metals detected in the strip solutions collected from the BSi beads Fajans adsorption generator points towards a very workable separation system
Cataloging source
MUU
http://library.link/vocab/creatorDate
1980-
http://library.link/vocab/creatorName
Chang, Yu-Wen
Degree
Ph. D.
Dissertation year
2009.
Granting institution
University of Missouri--Columbia
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Cutler, Cathy S.
http://library.link/vocab/subjectName
  • Germanium
  • Gallium
  • Radionuclide generators
  • Tomography, Emission
Target audience
specialized
Label
Development and evaluation of a novel germanium-68/gallium-68 generator, by Yu-Wen Chang, (electronic resource)
Instantiates
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011)
  • Thesis advisor: Dr. Cathy S. Cutler
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
698780427
Extent
1 online resource (xi, 67 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Specific material designation
remote
System control number
(OCoLC)698780427
Label
Development and evaluation of a novel germanium-68/gallium-68 generator, by Yu-Wen Chang, (electronic resource)
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011)
  • Thesis advisor: Dr. Cathy S. Cutler
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
698780427
Extent
1 online resource (xi, 67 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Specific material designation
remote
System control number
(OCoLC)698780427

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