The Resource Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III), by Valerie Carroll

Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III), by Valerie Carroll

Label
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III)
Title
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III)
Statement of responsibility
by Valerie Carroll
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Rhodium-105 is an attractive nuclide for radiotherapeutic applications due to its nuclear properties (566 keV Ý-, 319 keV [19%], 306 keV [5%]) and the kinetic stability of Rhodium (III) complexes with soft sulfur donor atoms. Extension of previous research involving tetrathioether chelate systems to include a targeting molecule may have implications for prostate cancer therapy. This work reports on the synthesis and evaluation of a new bombesin peptide targeted Rh (III) tetrathioether analogue, [Rh-S4-8Aoc-BBN(7-14)NH2]+, which shows high affinity for the BB2r receptor on PC-3 cancer cells (IC50 = 2.2 ± 0.3 nM). However, multiple 105Rh labeled species were obtained under the radiolabeling conditions investigated. To better understand the results observed for [105Rh-8Aoc-BBN(7-14)NH2]+, the chemistries of previously investigated [Rh-S4-Diol]+ and [Rh-S4-(COOH)2]+ were re-evaluated using more recently available techniques. A quantitative evaluation of the [Rh-S4-Diol]+ and [Rh-S4-(COOH)2]+ systems using NMR, ESI-MS and HPLC reveals formation of multiple species resulting from both exchange of the coordinated chlorides at the metal center and esterification of pendant carboxylate groups. While a predominate trans-chloro Rh(III)-S4 species may be favored by addition of excess NaCl, both ethanol and acid are required for radiolabeling. Thus, ligand systems utilizing pendant carboxylate groups are not compatible with traditional 105Rh radiolabeling techniques. Future studies involving a 105Rh tetrathioether bombesin analogue without pendant carboxylate groups are recommended
Cataloging source
MUU
http://library.link/vocab/creatorName
Carroll, Valerie
Degree
Ph. D.
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
  • illustrations
  • charts
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • theses
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Jurisson, Silvia S.
  • Hoffman, Timothy
http://library.link/vocab/subjectName
  • Prostate
  • Radiopharmaceuticals
Label
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III), by Valerie Carroll
Instantiates
Publication
Note
  • The entire dissertation text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description and public abstract appear in the public.pdf file
  • Dissertation Supervisors: Dr. Silvia Jurisson and Dr. Timothy Hoffman
  • Vita
  • "The work was funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Training Grant (1T32EB004822) and a Department of Defense Prostate Cancer Research Program (DOD PCRP) graduate training fellowship (W81XWH-11-1-0406)."--Page iii
Bibliography note
Includes bibliographical references (pages 67-74)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
863059235
Extent
1 online resource (x, 94 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations, charts.
Specific material designation
remote
System control number
(OCoLC)863059235
Label
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for [superscript]105Rh(III), by Valerie Carroll
Publication
Note
  • The entire dissertation text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description and public abstract appear in the public.pdf file
  • Dissertation Supervisors: Dr. Silvia Jurisson and Dr. Timothy Hoffman
  • Vita
  • "The work was funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Training Grant (1T32EB004822) and a Department of Defense Prostate Cancer Research Program (DOD PCRP) graduate training fellowship (W81XWH-11-1-0406)."--Page iii
Bibliography note
Includes bibliographical references (pages 67-74)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
863059235
Extent
1 online resource (x, 94 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations, charts.
Specific material designation
remote
System control number
(OCoLC)863059235

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