The Resource Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
Resource Information
The item Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from all library branches.
Resource Information
The item Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from all library branches.
- Summary
- OBJECTIVES: To report the evidence on comparative accuracy and safety of methods used in current clinical practice to diagnose celiac disease, including serological tests, human leukocyte antigen (HLA) typing, and video capsule endoscopy. Diagnostic tests used singly and in combination in various populations were compared against the reference standard of endoscopic duodenal biopsy. In addition, factors affecting biopsy accuracy were reviewed. DATA SOURCES: Electronic searches of PubMed(r), Embase(r), the Cochrane Library, and Web of Science from 1990 through March 2015. Reference lists of included publications were searched for additional relevant studies, and experts were asked to suggest studies. REVIEW METHODS: Studies of diagnostic accuracy were included if all participants underwent the index test and endoscopy with duodenal biopsy as the reference standard. Systematic reviews on accuracy and studies on adverse events associated with testing were included. Standard assessment tools were used to evaluate study risk of bias. Where possible, results of accuracy studies were pooled using meta-analysis. When pooling was not possible, findings were described narratively and presented in tables and figures. RESULTS: A total of 7,254 titles were identified, from which 60 individual studies and 13 prior systematic reviews were included. The majority of studies were conducted in participants with symptoms. New meta-analyses found high-strength evidence to support excellent accuracy of anti-tissue transglutaminase (tTG) immunoglobulin A (IgA) tests (sensitivity = 92.5%; specificity = 97.9%) and excellent specificity of endomysial antibodies (EmA) IgA tests (sensitivity = 79.0%; specificity = 99.0%), as reported in previous systematic reviews. Promising results were reported for deamidated gliadin peptide antibodies (DGP) IgA tests (sensitivity = 87.8%; specificity = 94.1%) in a recent meta-analysis. Evidence for algorithms using multiple tests was insufficient because of diverse results, low number of studies, and heterogeneity of populations. Evidence was also insufficient for accuracy in asymptomatic general population screening and special populations such as children and patients with type 1 diabetes, anemia, and IgA deficiency. CONCLUSIONS: New evidence on accuracy of tests used to diagnose celiac disease supports the excellent sensitivity of tTG IgA tests and excellent specificity of both tTG IgA and EmA IgA tests. Sensitivity of DGP IgA and immunoglobulin G tests is slightly less than for tTG IgA. Additional studies are needed to confirm the accuracy of diagnostic tests in special populations and to validate promising algorithms
- Language
- eng
- Extent
- 1 online resource (various pagings)
- Note
- "January 2016."
- Label
- Diagnosis of celiac disease
- Title
- Diagnosis of celiac disease
- Statement of responsibility
- prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
- Language
- eng
- Summary
- OBJECTIVES: To report the evidence on comparative accuracy and safety of methods used in current clinical practice to diagnose celiac disease, including serological tests, human leukocyte antigen (HLA) typing, and video capsule endoscopy. Diagnostic tests used singly and in combination in various populations were compared against the reference standard of endoscopic duodenal biopsy. In addition, factors affecting biopsy accuracy were reviewed. DATA SOURCES: Electronic searches of PubMed(r), Embase(r), the Cochrane Library, and Web of Science from 1990 through March 2015. Reference lists of included publications were searched for additional relevant studies, and experts were asked to suggest studies. REVIEW METHODS: Studies of diagnostic accuracy were included if all participants underwent the index test and endoscopy with duodenal biopsy as the reference standard. Systematic reviews on accuracy and studies on adverse events associated with testing were included. Standard assessment tools were used to evaluate study risk of bias. Where possible, results of accuracy studies were pooled using meta-analysis. When pooling was not possible, findings were described narratively and presented in tables and figures. RESULTS: A total of 7,254 titles were identified, from which 60 individual studies and 13 prior systematic reviews were included. The majority of studies were conducted in participants with symptoms. New meta-analyses found high-strength evidence to support excellent accuracy of anti-tissue transglutaminase (tTG) immunoglobulin A (IgA) tests (sensitivity = 92.5%; specificity = 97.9%) and excellent specificity of endomysial antibodies (EmA) IgA tests (sensitivity = 79.0%; specificity = 99.0%), as reported in previous systematic reviews. Promising results were reported for deamidated gliadin peptide antibodies (DGP) IgA tests (sensitivity = 87.8%; specificity = 94.1%) in a recent meta-analysis. Evidence for algorithms using multiple tests was insufficient because of diverse results, low number of studies, and heterogeneity of populations. Evidence was also insufficient for accuracy in asymptomatic general population screening and special populations such as children and patients with type 1 diabetes, anemia, and IgA deficiency. CONCLUSIONS: New evidence on accuracy of tests used to diagnose celiac disease supports the excellent sensitivity of tTG IgA tests and excellent specificity of both tTG IgA and EmA IgA tests. Sensitivity of DGP IgA and immunoglobulin G tests is slightly less than for tTG IgA. Additional studies are needed to confirm the accuracy of diagnostic tests in special populations and to validate promising algorithms
- Cataloging source
- NLM
- http://library.link/vocab/creatorName
- Maglione, Margaret
- Funding information
- Prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Southern California Evidence-Based Practice Center
- Government publication
- federal national government publication
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- surveys of literature
- NLM call number
- WD 175
- http://library.link/vocab/relatedWorkOrContributorName
-
- Effective Health Care Program (U.S.)
- United States
- Southern California Evidence-Based Practice Center/RAND
- Series statement
-
- Comparative effectiveness reviews
- AHRQ publication
- Series volume
-
- number 162
- no. 15(16)-EHC032- EF
- http://library.link/vocab/subjectName
-
- Celiac Disease
- Serologic Tests
- HLA Antigens
- Capsule Endoscopy
- Biopsy
- Comparative Effectiveness Research
- Label
- Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
- Note
- "January 2016."
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
- cr
- Carrier MARC source
- rdacarrier
- Content category
-
- text
- still image
- Content type code
-
- txt
- sti
- Content type MARC source
-
- rdacontent
- rdacontent
- Control code
- 948243379
- Extent
- 1 online resource (various pagings)
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
- c
- Specific material designation
- remote
- System control number
- (OCoLC)948243379
- Label
- Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
- Note
- "January 2016."
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
- cr
- Carrier MARC source
- rdacarrier
- Content category
-
- text
- still image
- Content type code
-
- txt
- sti
- Content type MARC source
-
- rdacontent
- rdacontent
- Control code
- 948243379
- Extent
- 1 online resource (various pagings)
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
- c
- Specific material designation
- remote
- System control number
- (OCoLC)948243379
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Diagnosis-of-celiac-disease-prepared-for-Agency/cV7vT2eFfLk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Diagnosis-of-celiac-disease-prepared-for-Agency/cV7vT2eFfLk/">Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
