The Resource Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon

Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon

Label
Diagnosis of celiac disease
Title
Diagnosis of celiac disease
Statement of responsibility
prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
Creator
Contributor
Author
Issuing body
Sponsoring body
Subject
Genre
Language
eng
Summary
OBJECTIVES: To report the evidence on comparative accuracy and safety of methods used in current clinical practice to diagnose celiac disease, including serological tests, human leukocyte antigen (HLA) typing, and video capsule endoscopy. Diagnostic tests used singly and in combination in various populations were compared against the reference standard of endoscopic duodenal biopsy. In addition, factors affecting biopsy accuracy were reviewed. DATA SOURCES: Electronic searches of PubMed(r), Embase(r), the Cochrane Library, and Web of Science from 1990 through March 2015. Reference lists of included publications were searched for additional relevant studies, and experts were asked to suggest studies. REVIEW METHODS: Studies of diagnostic accuracy were included if all participants underwent the index test and endoscopy with duodenal biopsy as the reference standard. Systematic reviews on accuracy and studies on adverse events associated with testing were included. Standard assessment tools were used to evaluate study risk of bias. Where possible, results of accuracy studies were pooled using meta-analysis. When pooling was not possible, findings were described narratively and presented in tables and figures. RESULTS: A total of 7,254 titles were identified, from which 60 individual studies and 13 prior systematic reviews were included. The majority of studies were conducted in participants with symptoms. New meta-analyses found high-strength evidence to support excellent accuracy of anti-tissue transglutaminase (tTG) immunoglobulin A (IgA) tests (sensitivity = 92.5%; specificity = 97.9%) and excellent specificity of endomysial antibodies (EmA) IgA tests (sensitivity = 79.0%; specificity = 99.0%), as reported in previous systematic reviews. Promising results were reported for deamidated gliadin peptide antibodies (DGP) IgA tests (sensitivity = 87.8%; specificity = 94.1%) in a recent meta-analysis. Evidence for algorithms using multiple tests was insufficient because of diverse results, low number of studies, and heterogeneity of populations. Evidence was also insufficient for accuracy in asymptomatic general population screening and special populations such as children and patients with type 1 diabetes, anemia, and IgA deficiency. CONCLUSIONS: New evidence on accuracy of tests used to diagnose celiac disease supports the excellent sensitivity of tTG IgA tests and excellent specificity of both tTG IgA and EmA IgA tests. Sensitivity of DGP IgA and immunoglobulin G tests is slightly less than for tTG IgA. Additional studies are needed to confirm the accuracy of diagnostic tests in special populations and to validate promising algorithms
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Maglione, Margaret
Funding information
Prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Southern California Evidence-Based Practice Center
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • surveys of literature
NLM call number
WD 175
http://library.link/vocab/relatedWorkOrContributorName
  • Effective Health Care Program (U.S.)
  • United States
  • Southern California Evidence-Based Practice Center/RAND
Series statement
  • Comparative effectiveness reviews
  • AHRQ publication
Series volume
  • number 162
  • no. 15(16)-EHC032- EF
http://library.link/vocab/subjectName
  • Celiac Disease
  • Serologic Tests
  • HLA Antigens
  • Capsule Endoscopy
  • Biopsy
  • Comparative Effectiveness Research
Label
Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
Instantiates
Publication
Note
"January 2016."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
948243379
Extent
1 online resource (various pagings)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)948243379
Label
Diagnosis of celiac disease, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Southern California Evidence-Based Practice Center ; investigators, Margaret A Maglione, Adeyemi Okunogbe, Brett Ewing, Sean Grant, Sydne J. Newberry, Aneesa Motala, Roberta Shanman, Nelly Mejia, Aziza Arifkhanova, Paul Shekelle, Gregory Harmon
Publication
Note
"January 2016."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
948243379
Extent
1 online resource (various pagings)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)948243379

Library Locations

  • St. Louis Mercantile LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • Thomas Jefferson LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • University ArchivesBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • Ward E Barnes Education LibraryBorrow it
    8001 Natural Bridge Rd, St. Louis, MO, 63121, US
    38.707079 -90.311355
Processing Feedback ...