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The Resource Drug design strategies : quantitative approaches, edited by David J. Livingstone, Andrew M. Davis

Drug design strategies : quantitative approaches, edited by David J. Livingstone, Andrew M. Davis

Label
Drug design strategies : quantitative approaches
Title
Drug design strategies
Title remainder
quantitative approaches
Statement of responsibility
edited by David J. Livingstone, Andrew M. Davis
Contributor
Subject
Language
eng
Summary
This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of quantitative approaches, a survey/summary of the current state-of-the-art, a selection of well chosen examples with some worked through and an appreciation of what problems remain to be overcome as well as an indication of how the field may develop. After an overview of quantitative approaches to drug design the book describes the development of concepts of "drug-like properties", of quantitative structure-activity relationships and molecular modelling, and in particular, structure-based design approaches to guide lead optimisation. How to manage and describe chemical structures, underpins all quantitative approaches to drug design and these are described in the following chapters. The next chapter covers the value of a quantitative approach, and also the challenge which is to describe the confidence in any prediction, and methods to assess predictive model quality. The later chapters describe the application of quantitative approaches to describing and optimising potency, selectivity, drug metabolism and pharmacokinetic properties and toxicology, and the design of chemical libraries to feed the screening approaches to lead generation that underpin modern drug discovery. Finally the book describes the impact of bioinformatics, current status of predicting ligand affinity direct from the protein structure, and the application of quantitative approaches to predicting environmental risk. The book provides a summary of the current state-of-the-art in quantitative approaches to drug design, and future opportunities, but it also provides inspiration to drug design practitioners to apply careful design, to make best use of the quantitative methods that are available, while continuing to improve them. Drug discovery still relies heavily on random screening and empirical screening cascades to identify leads and drugs and the process has many failures to deliver only a small handful of drugs. With the rapidly escalating costs of drug discovery and development together with spiralling delivery, quantitative approaches hold the promise of shifting the balance of success, to enable drug discovery to maintain its economic viability
Member of
Cataloging source
COO
Dewey number
615.19
Illustrations
illustrations
Index
index present
LC call number
RS420
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 744
http://library.link/vocab/relatedWorkOrContributorName
  • Livingstone, D.
  • Davis, Andrew M.
Series statement
RSC Drug Discovery Series
Series volume
no. 13
http://library.link/vocab/subjectName
  • Drugs
  • Drug Design
  • Drug Discovery
  • Computer Simulation
  • Decision Support Techniques
  • Models, Chemical
  • Models, Molecular
  • Quantitative Structure-Activity Relationship
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Drugs
Label
Drug design strategies : quantitative approaches, edited by David J. Livingstone, Andrew M. Davis
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
798795445
Dimensions
unknown
Extent
1 online resource (516 pages)
Form of item
online
Isbn
9781849731676
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1039/9781849733410
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)798795445
Label
Drug design strategies : quantitative approaches, edited by David J. Livingstone, Andrew M. Davis
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
798795445
Dimensions
unknown
Extent
1 online resource (516 pages)
Form of item
online
Isbn
9781849731676
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1039/9781849733410
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)798795445

Library Locations

    • Thomas Jefferson LibraryBorrow it
      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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