The Resource Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Minnesota Evidence-based Practice Center ; investigators, Mary Butler [and others], (electronic resource)

Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Minnesota Evidence-based Practice Center ; investigators, Mary Butler [and others], (electronic resource)

Label
Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection
Title
Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection
Statement of responsibility
prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Minnesota Evidence-based Practice Center ; investigators, Mary Butler [and others]
Contributor
Subject
Genre
Language
eng
Summary
OBJECTIVES: To conduct a systematic review and synthesize evidence for differences in the accuracy of diagnostic tests, and the effects of interventions to prevent and treat Clostridium difficile infection (CDI) in adult patients. DATA SOURCES: Searching for relevant literature was conducted in MEDLINE, the Cochrane Library, and Allied and Complementary Medicine (AMED). ClinicalTrials.gov and expert consultants provided leads to additional studies. We also manually searched reference lists from relevant literature. REVIEW METHODS: Standard Evidence-based Practice Center methods were employed. Screening of abstracts and full text articles to identify studies meeting inclusion/exclusion criteria was performed by two independent reviewers. High-quality direct comparison studies were used to examine differences in diagnostic tests. Randomized controlled trials (RCTs) were used to examine comparative effectiveness of antibiotic treatment for CDI. Quality of data extraction was checked by separate reviewers. Quality ratings and strength of evidence grading was performed on included studies. Evidence on diagnostic tests was quantitatively synthesized focusing on differences between test sensitivities and specificities. Evidence on antibiotic treatment was quantitatively examined using pooled analysis. Qualitative narrative analysis was used to synthesize evidence from all available study types for environmental prevention and nonstandard prevention and treatment, with the exception of probiotics as primary prevention, for which a forest plot is provided. RESULTS: Overall, literature was sparse and strength of evidence was generally low due to small sample sizes or lack of adequate controls. For diagnostic testing, direct comparisons of commercially available enzyme immunoassays for C. difficile toxins A and B did not find major differences in sensitivity or specificity. Limited evidence suggests that tests for genes related to the production of C. difficile toxins may be more sensitive than immunoassays for toxins A and B while the comparisons of these test specificities were inconsistent. Moderate evidence in favor of antibiotic restriction policies for prevention was found. Environmental preventive interventions such as glove use and disposable thermometers have limited evidence. However, this literature is largely based on controlling outbreaks. Use of multiple component interventions further limits the ability to synthesize evidence in a meaningful way. Numerous potential new forms of treatment are being examined in placebo controlled RCTs, case series, and case reports. For standard treatment, no antimicrobial is clearly superior for the initial cure of CDI. Recurrence is less frequent with fidaxomicin than with vancomycin. Monoclonal antibodies for prevention and fecal flora reconstitution for multiple recurrences appear promising. CONCLUSIONS: Given the frequency and severity of CDI and the fact that future reimbursement policy may withhold payment for hospital-acquired infections, this is an under-researched topic. More precise estimates of the magnitude of differences in test sensitivities and specificities are needed. More importantly, studies have not established that any of the possible differences in test accuracy would lead to substantially different patient outcomes in clinical practice. More research on effective treatment and unintended consequences of treatment, such as resistance, is needed. Gut flora may be important, but improved understanding of healthy gut ecology and the complex interactions is necessary before continuing to pursue probiotics
Member of
Cataloging source
NLM
Funding information
Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by: Minnesota Evidence-based Practice Center, Minneapolis, Minnesota
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WI 420
http://library.link/vocab/relatedWorkOrContributorDate
active 2008
http://library.link/vocab/relatedWorkOrContributorName
  • Butler, Mary
  • United States
  • Effective Health Care Program (U.S.)
  • Minnesota Evidence-based Practice Center
  • Effective Health Care Program (U.S.)
Series statement
  • Comparative effectiveness review
  • AHRQ publication
Series volume
  • no. 31
  • no. 12-EHC010-EF
http://library.link/vocab/subjectName
  • Enterocolitis, Pseudomembranous
  • Early Diagnosis
  • Enterocolitis, Pseudomembranous
  • Enterocolitis, Pseudomembranous
http://bibfra.me/vocab/relation/supportingbody
RzTDSdffmEM
Label
Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Minnesota Evidence-based Practice Center ; investigators, Mary Butler [and others], (electronic resource)
Instantiates
Publication
Note
  • "December 2011."
  • "Contract No. 290-02-0009 (EPC2)."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
789838432
Extent
1 online resource (263 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)789838432
Label
Effectiveness of early diagnosis, prevention, and treatment of Clostridium difficile infection, prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, Minnesota Evidence-based Practice Center ; investigators, Mary Butler [and others], (electronic resource)
Publication
Note
  • "December 2011."
  • "Contract No. 290-02-0009 (EPC2)."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
789838432
Extent
1 online resource (263 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)789838432

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