The Resource Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by University of Connecticut/Hartford Evidence-based Practice Center ; investigators, Olivia J. Phung [and others], (electronic resource)

Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by University of Connecticut/Hartford Evidence-based Practice Center ; investigators, Olivia J. Phung [and others], (electronic resource)

Label
Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis
Title
Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis
Statement of responsibility
prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by University of Connecticut/Hartford Evidence-based Practice Center ; investigators, Olivia J. Phung [and others]
Contributor
Subject
Genre
Language
eng
Summary
OBJECTIVES: This is an evidence report prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center (EPC) examining the benefits and harms associated with using recombinant human growth hormone (rhGH) in patients with cystic fibrosis (CF). CONCLUSIONS: rhGH improved almost all intermediate measures of pulmonary function, height, and weight in patients with CF. Improvements in bone mineral content are also promising. However, with the exception of hospitalizations, the benefits on final health outcomes cannot be directly determined at this time. In the relatively low doses used in CF patients for a time period of 6 to 12 months, rhGH therapy may worsen short term markers of glucose control but may not impact long terms glucose control. The increase in IGF-I with rhGH therapy is above a threshold thought to increase the risk of malignancy but the strength of this marker in determining malignancy is not firmly established
Member of
Cataloging source
NLM
Funding information
Contract No. 290-2007-10067-I.
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WI 820
http://library.link/vocab/relatedWorkOrContributorName
  • Phung, Olivia J
  • United States
  • University of Connecticut-Hartford Hospital Evidence-based Practice Center
  • Effective Health Care Program (U.S.)
Series statement
  • Comparative effectiveness review
  • AHRQ publication
Series volume
  • no. 23
  • no. 11-EHC003-EF
http://library.link/vocab/subjectName
  • Cystic Fibrosis
  • Evidence-Based Medicine
  • Human Growth Hormone
http://bibfra.me/vocab/relation/supportingbody
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Label
Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by University of Connecticut/Hartford Evidence-based Practice Center ; investigators, Olivia J. Phung [and others], (electronic resource)
Instantiates
Publication
Note
"October 2010."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
780224026
Extent
1 online resource
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)780224026
Label
Effectiveness of recombinant human growth hormone (rhGH) in the treatment of patients with cystic fibrosis, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by University of Connecticut/Hartford Evidence-based Practice Center ; investigators, Olivia J. Phung [and others], (electronic resource)
Publication
Note
"October 2010."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
780224026
Extent
1 online resource
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)780224026

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