The Resource Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system, by Maren Bell Jones, (electronic resource)

Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system, by Maren Bell Jones, (electronic resource)

Label
Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system
Title
Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system
Statement of responsibility
by Maren Bell Jones
Title variation
Effects and interactions of diet and endocrine disrupting chemicals on the mouse reproductive system
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Recent studies have indicated that a number of ubiquitous chemicals found in the environment are linked to a myriad of health concerns, including reproductive abnormalities and increases in infertility, cancer, and obesity via their actions as exogenous hormones. Because of the importance of evaluating the effects of these chemicals in living model organisms, maintaining the sensitivity of various bioassays as indicators of hormone action is critical. One source of variability is the isoflavones (a type of hormonally active phytoestrogen) in soy-based rodent diets. If the background levels of these diets are too high, they can interfere with the body's response to an endocrine disrupting chemical. Our studies showed that variability within the phytoestrogen levels in different brands and lots of diets can cause changes in sensitive bioassays such as the fetal estradiol levels, uterotrophic response to estrogen, the timing of the onset of puberty, and the amount of gonadal fat as adults. In addition, maintaining the animals on various brands with varying background levels of phytoestrogens yielded different endpoints when the animals were exposed to a prenatal dose of the known endocrine disrupting chemical diethylstilbestrol. We conclude that sensitive endpoints used to determine the effects of environmental endocrine disrupting chemicals are affected by varying background levels of phytoestrogens
Cataloging source
MUU
http://library.link/vocab/creatorDate
1982-
http://library.link/vocab/creatorName
Jones, Maren Bell
Degree
M.A.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Vom Saal, Frederick S.
http://library.link/vocab/subjectName
  • Endocrine toxicology
  • Endocrine glands
  • Mice
Target audience
specialized
Label
Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system, by Maren Bell Jones, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on October 29, 2007)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
179693198
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)179693198
System details
Mode of access: World Wide Web
Label
Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system, by Maren Bell Jones, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on October 29, 2007)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
179693198
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)179693198
System details
Mode of access: World Wide Web

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