The Resource Effects of aflatoxin on hepatic gene expression in a poultry model, by Lakshmi Praveema Yarru, (electronic resource)

Effects of aflatoxin on hepatic gene expression in a poultry model, by Lakshmi Praveema Yarru, (electronic resource)

Label
Effects of aflatoxin on hepatic gene expression in a poultry model
Title
Effects of aflatoxin on hepatic gene expression in a poultry model
Statement of responsibility
by Lakshmi Praveema Yarru
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
To determine the effects of dietary aflatoxin on hepatic gene expression in chicks, seventy five day old-male broiler chicks were assigned to three dietary treatments (0, 1 and 2 mg/kg aflatoxin/kg of feed) from hatch to day 21. At the end of the study, feed intake, body and liver weights and serum chemistry were evaluated and hepatic RNA was used to determine the hepatic gene expression associated with aflatoxin diet intake using microarrays and real time PCR. Aflatoxin diet reduced feed intake, body weight, serum total proteins, calcium and phosphorus and increased liver weights in dose dependent manner. The diet down-regulated the genes associated with energy metabolism, growth and development, antioxidant and immune protection and up-regulated the genes associated with cell proliferation. In the subsequent study, beneficial effects of boosting the antioxidant system through feeding a diet containing turmeric (1.48% Curcuma longa) to aflatoxin diet fed birds on physiological and hepatic gene expression was evaluated. Aflatoxin reduced feed intake and body weight gain, and increased relative liver weight. Addition of curcumin to the AF diet ameliorated the negative effects of AF on growth performance and liver weight. Decreased expression of antioxidants genes and increased expression of interleukins and cytochrome P450s due to AF was alleviated by the inclusion of curcumin in the diet. The current study demonstrates a protective effect of curcumin on gene expression in livers of chicks fed AF
Cataloging source
MUU
http://library.link/vocab/creatorName
Yarru, Lakshmi Praveema
Degree
M.S.
Dissertation year
2008.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
Ledoux, David R.
http://library.link/vocab/subjectName
  • Chicks
  • Chicks
  • Liver
  • Aflatoxins
  • Gene expression
Target audience
specialized
Label
Effects of aflatoxin on hepatic gene expression in a poultry model, by Lakshmi Praveema Yarru, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on September 19, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
253629838
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)253629838
System details
Mode of access: World Wide Web
Label
Effects of aflatoxin on hepatic gene expression in a poultry model, by Lakshmi Praveema Yarru, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on September 19, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
253629838
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)253629838
System details
Mode of access: World Wide Web

Library Locations

  • St. Louis Mercantile LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • Thomas Jefferson LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • University ArchivesBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • Ward E Barnes Education LibraryBorrow it
    8001 Natural Bridge Rd, St. Louis, MO, 63121, US
    38.707079 -90.311355
Processing Feedback ...