The Resource Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice, by Jie Ning, (electronic resource)

Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice, by Jie Ning, (electronic resource)

Label
Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice
Title
Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice
Statement of responsibility
by Jie Ning
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice
Cataloging source
MMU
http://library.link/vocab/creatorName
Ning, Jie
Degree
M.S.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Brown, Marybeth
http://library.link/vocab/subjectName
  • Estrogen
  • Estrogen
  • Transgenic mice
  • Muscles
  • Aromatase
  • Muscle contraction
Target audience
specialized
Label
Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice, by Jie Ning, (electronic resource)
Instantiates
Publication
Note
  • "August 2007"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
182537850
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campuses of the University of Missouri
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)182537850
System details
Mode of access: World Wide Web
Label
Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice, by Jie Ning, (electronic resource)
Publication
Note
  • "August 2007"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
182537850
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campuses of the University of Missouri
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)182537850
System details
Mode of access: World Wide Web

Library Locations

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      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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