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The Resource Evaluation and treatment of tinnitus : comparative effectiveness, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by McMaster University Evidence-based Practice Center ; investigators, M. Kathleen Pichora-Fuller, Ph.D., Pasqualina Santaguida, Ph.D., Amanda Hammill, M.A., Mark Oremus, Ph.D., Brian Westerberg, M.D., Usman Ali, M.D., M.Sc., Christopher Patterson, M.D., Parminder Raina, Ph.D

Evaluation and treatment of tinnitus : comparative effectiveness, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by McMaster University Evidence-based Practice Center ; investigators, M. Kathleen Pichora-Fuller, Ph.D., Pasqualina Santaguida, Ph.D., Amanda Hammill, M.A., Mark Oremus, Ph.D., Brian Westerberg, M.D., Usman Ali, M.D., M.Sc., Christopher Patterson, M.D., Parminder Raina, Ph.D

Creator
Author
Contributor
Summary
OBJECTIVES: A review was undertaken to evaluate the peer-reviewed literature on three areas of tinnitus management for the following Key Questions (KQs): (1) measures used to assess patients for management needs (KQ1); (2) effectiveness of treatments (KQ2); and (3) identification of prognostic factors (KQ3). DATA SOURCES: MEDLINE(r), Embase(r), CINAHL(r), PsycINFO(r), AMED(c), and Cochrane CENTRAL were searched from January 1970 to June 2012. An extensive grey literature search, which included documents from regulatory and tinnitus-related organizations, was also undertaken. REVIEW METHODS: Standardized systematic review methodology was employed. Eligibility criteria included English-language studies of adults with subjective idiopathic (nonpulsatile) tinnitus; excluded studies involved tinnitus as the result of middle-ear pathologies or focused on methods to determine psychosomatic tinnitus. For KQ2, all pharmacological/food supplement, medical/surgical, sound/technological, and psychological/behavioral interventions aimed at ameliorating tinnitus symptoms were eligible (except stapedectomy or tympanoplasty). Randomized controlled trials with placebo controls or head-to-head trials were eligible for all KQs. RESULTS: From 9,725 citations, 52 eligible publications were extracted for data. None were eligible for KQ1 or KQ3. From the 52 publications eligible for KQ2, 17 evaluated pharmacological interventions; 11 evaluated medical interventions (low-level laser, acupuncture, transcranial magnetic stimulation); 5 evaluated sound technologies; and 19 evaluated psycholocal/behavioral interventions. Data on adverse effects were generally poorly collected and reported. CONCLUSIONS: There is low strength of evidence (SOE) indicating that cognitive behavioral therapy interventions improve tinnitus-specific quality of life relative to inactive controls. For pharmacological interventions, SOE is low for improvements to subjective loudness from neurotransmitter drugs versus placebo; insufficient for antidepressants, other drugs, and food supplements with respect to subjective loudness; and insufficient for all other outcomes. There is insufficient SOE to suggest that medical interventions improve outcomes relative to inactive controls; sleep and global quality of life were not evaluated for medical interventions. The SOE for the adverse effect of sedation in pharmacological studies was judged insufficient. Future research should address the substantial gaps identified for KQ1 and KQ3. For KQ2, future research should concentrate on improving collection of adverse effects, calculating sample size, and specifying doses for interventions
Language
eng
Work
Publication
Extent
1 online resource (294 pages)
Note
"August 2013."
Instance
Label
Evaluation and treatment of tinnitus : comparative effectiveness
Title
Evaluation and treatment of tinnitus
Title remainder
comparative effectiveness
Statement of responsibility
prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by McMaster University Evidence-based Practice Center ; investigators, M. Kathleen Pichora-Fuller, Ph.D., Pasqualina Santaguida, Ph.D., Amanda Hammill, M.A., Mark Oremus, Ph.D., Brian Westerberg, M.D., Usman Ali, M.D., M.Sc., Christopher Patterson, M.D., Parminder Raina, Ph.D
Title variation
Effective health care program
Creator
Contributor
Author
Issuing body
Subject
Genre
Language
eng
Summary
OBJECTIVES: A review was undertaken to evaluate the peer-reviewed literature on three areas of tinnitus management for the following Key Questions (KQs): (1) measures used to assess patients for management needs (KQ1); (2) effectiveness of treatments (KQ2); and (3) identification of prognostic factors (KQ3). DATA SOURCES: MEDLINE(r), Embase(r), CINAHL(r), PsycINFO(r), AMED(c), and Cochrane CENTRAL were searched from January 1970 to June 2012. An extensive grey literature search, which included documents from regulatory and tinnitus-related organizations, was also undertaken. REVIEW METHODS: Standardized systematic review methodology was employed. Eligibility criteria included English-language studies of adults with subjective idiopathic (nonpulsatile) tinnitus; excluded studies involved tinnitus as the result of middle-ear pathologies or focused on methods to determine psychosomatic tinnitus. For KQ2, all pharmacological/food supplement, medical/surgical, sound/technological, and psychological/behavioral interventions aimed at ameliorating tinnitus symptoms were eligible (except stapedectomy or tympanoplasty). Randomized controlled trials with placebo controls or head-to-head trials were eligible for all KQs. RESULTS: From 9,725 citations, 52 eligible publications were extracted for data. None were eligible for KQ1 or KQ3. From the 52 publications eligible for KQ2, 17 evaluated pharmacological interventions; 11 evaluated medical interventions (low-level laser, acupuncture, transcranial magnetic stimulation); 5 evaluated sound technologies; and 19 evaluated psycholocal/behavioral interventions. Data on adverse effects were generally poorly collected and reported. CONCLUSIONS: There is low strength of evidence (SOE) indicating that cognitive behavioral therapy interventions improve tinnitus-specific quality of life relative to inactive controls. For pharmacological interventions, SOE is low for improvements to subjective loudness from neurotransmitter drugs versus placebo; insufficient for antidepressants, other drugs, and food supplements with respect to subjective loudness; and insufficient for all other outcomes. There is insufficient SOE to suggest that medical interventions improve outcomes relative to inactive controls; sleep and global quality of life were not evaluated for medical interventions. The SOE for the adverse effect of sedation in pharmacological studies was judged insufficient. Future research should address the substantial gaps identified for KQ1 and KQ3. For KQ2, future research should concentrate on improving collection of adverse effects, calculating sample size, and specifying doses for interventions
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Pichora-Fuller, M. Kathleen
Funding information
Conducted by the McMaster University Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ)
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • surveys of literature
NLM call number
WV 272
http://library.link/vocab/relatedWorkOrContributorDate
1968-
http://library.link/vocab/relatedWorkOrContributorName
  • Santaguida, Pasqualina
  • Hammill, Amanda C.
  • Oremus, Mark
  • Westerberg, Brian
  • ʻAlī, ʻUsm̲ān
  • Patterson, Christopher
  • Raina, Parminder
  • Effective Health Care Program (U.S.)
  • United States
  • McMaster University
Series statement
  • Comparative effectiveness review
  • AHRQ publication
Series volume
  • number 122
  • no. 13-EHC110-EF
http://library.link/vocab/subjectName
  • Tinnitus
  • Comparative Effectiveness Research
http://bibfra.me/vocab/relation/supportingbody
  • RzTDSdffmEM
  • SGEpYsXqBGk
Label
Evaluation and treatment of tinnitus : comparative effectiveness, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by McMaster University Evidence-based Practice Center ; investigators, M. Kathleen Pichora-Fuller, Ph.D., Pasqualina Santaguida, Ph.D., Amanda Hammill, M.A., Mark Oremus, Ph.D., Brian Westerberg, M.D., Usman Ali, M.D., M.Sc., Christopher Patterson, M.D., Parminder Raina, Ph.D
Instantiates
Publication
Note
"August 2013."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
865151356
Extent
1 online resource (294 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)865151356
Label
Evaluation and treatment of tinnitus : comparative effectiveness, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by McMaster University Evidence-based Practice Center ; investigators, M. Kathleen Pichora-Fuller, Ph.D., Pasqualina Santaguida, Ph.D., Amanda Hammill, M.A., Mark Oremus, Ph.D., Brian Westerberg, M.D., Usman Ali, M.D., M.Sc., Christopher Patterson, M.D., Parminder Raina, Ph.D
Publication
Note
"August 2013."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
865151356
Extent
1 online resource (294 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)865151356

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