The Resource Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds, by Yinan Lin

Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds, by Yinan Lin

Label
Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds
Title
Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds
Statement of responsibility
by Yinan Lin
Creator
Author
Subject
Language
eng
Summary
"The main objective of this project was to evaluate the capacity of strong porous silicate (13-93) bioactive glass scaffolds prepared by a robocasting technique to regenerate bone and stimulate angiogenesis in a rat calvarial defect model. The scaffolds were created with the same grid-like microstructure but in a variety of formulations: (i) as-fabricated, (ii) pretreated in an aqueous phosphate solution to convert the glass surface to hydroxyapatite, (iii) loaded with bone morphogenetic protein-2 (BMP2) (1 [mu]g per scaffold), and (iv) doped with copper (0.4-2.0 wt. % CuO). When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at 6 weeks but not at 12 or 24 weeks. In comparison, the BMP2-loaded scaffolds enhanced bone regeneration at all three implantation times and they were almost completely infiltrated with lamellar bone within 12 weeks. Doping the as-fabricated scaffolds with 0.4 and 0.8 wt. % CuO did not affect the response of preosteoblastic MC3T3-E1 cells in vitro and bone regeneration in vivo. In comparison, the scaffolds doped with 2.0 wt. % CuO were toxic to the cells in vitro and significantly inhibited bone regeneration at 6 weeks post-implantation. The area of new blood vessels in the new bone that infiltrated the scaffolds at 6 weeks post-implantation was significantly enhanced by the BMP2 loading but not by CuO dopant concentrations of 0.4 and 0.8 wt. %. The fibrous tissue that infiltrated the scaffolds doped with 2.0 wt. % CuO showed a significantly higher blood vessel area than the as-fabricated scaffolds. Loading silicate 13-93 bioactive glass scaffolds with BMP2 significantly improved their capacity to regenerate bone in rat calvarial defects at 6 weeks post-implantation when compared to doping the glass with copper"--Abstract, page iv
Related
Member of
Cataloging source
UMR
http://library.link/vocab/creatorDate
1988-
http://library.link/vocab/creatorName
Lin, Yinan
Degree
M.S.
Dissertation year
2015
Granting institution
Missouri University of Science and Technology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/subjectName
  • Bone regeneration
  • Tissue scaffolds
  • Bioactive compounds
  • Glass in medicine
  • Three-dimensional printing
Label
Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds, by Yinan Lin
Instantiates
Publication
Note
  • Vita
  • This dissertation contains two papers for publication
Bibliography note
Includes bibliographic references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
936208262
Extent
1 online resource (xii, 88 pages)
Form of item
online
Governing access note
These materials are protected under copyright by the original author
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some colored).
Specific material designation
remote
System control number
(OCoLC)936208262
Label
Healing of bone defects in a rodent calvarial defect model using strong porous bioactive glass (13-93) scaffolds, by Yinan Lin
Publication
Note
  • Vita
  • This dissertation contains two papers for publication
Bibliography note
Includes bibliographic references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
936208262
Extent
1 online resource (xii, 88 pages)
Form of item
online
Governing access note
These materials are protected under copyright by the original author
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some colored).
Specific material designation
remote
System control number
(OCoLC)936208262

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