The Resource Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease : Insights from the PORTRAIT Registry, by Krishna Kaushik Patel

Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease : Insights from the PORTRAIT Registry, by Krishna Kaushik Patel

Label
Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease : Insights from the PORTRAIT Registry
Title
Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease
Title remainder
Insights from the PORTRAIT Registry
Statement of responsibility
by Krishna Kaushik Patel
Creator
Contributor
Author
Degree supervisor
Subject
Genre
Language
eng
Summary
Patients with peripheral artery disease (PAD) and coexisting diabetes mellitus (DM) have an increased rate of PAD progression and reduced walking performance as compared with non-diabetic PAD patients. It is unknown, however, whether patients with PAD and comorbid diabetes also experience worse PAD-specific health status (symptoms, functional status, quality of life) and how that changes over time. The Patient-centered Outcomes Related to Treatment practices in peripheral Arterial disease: Investigating Trajectories (PORTRAIT) is a 16-center international registry that includes patients with exacerbated or new-onset symptomatic PAD presenting to specialty clinics. PAD-specific health status was measured at the time of initial PAD evaluation and 12 months later using the Peripheral Artery Questionnaire (PAQ). Multivariable linear regression, initially adjusted for demographics (partially adjustment) and then additionally adjusted for socioeconomic factors, PAD severity, comorbidities, psychosocial characteristics (fully adjusted), was used to assess the association between DM and health status at baseline and at 12 months. Interaction of diabetes with invasive PAD treatment on 12-month health status was tested to assess for the differential effect of treatment on follow-up health status by diabetes status. Of 1,204 patients, 397 patients had diabetes (96% Type II). Patients with PAD and DM had lower unadjusted PAQ summary scores at baseline, 3, 6 and 12 months, compared to patients with PAD without diabetes (46.1 vs. 50.8, p < 0.001; 63.6 vs. 68.2, p < 0.01; 65.6 vs. 71.7, p < 0.001; 65.3 vs. 72.6, p<0.001). After adjusting for age, sex, race and country; patients with diabetes had worse PAQ summary scores at baseline (mean difference= -4.04 (-6.58, -1.50), p <0.01) and at 12 months (mean difference= -6.06 (-9.13, -2.99), p<0.01). After additionally adjusting for socioeconomic, comorbidities, psychosocial characteristics and PAD severity (fully adjusted), the effect of diabetes on PAQ summary score at baseline (adjusted mean difference= -1.80 (-4.42, 0.82), p=0.18) and 12 months (adjusted mean difference= -2.11, (95% CI: -5.32, 1.11; p=0.20)) was no longer significant. There was no differential effect of invasive treatment on 12-month PAQ scores by patient diabetes status (diabetes*invasive treatment p{u2265}0.32).In conclusion, patients with PAD and co-existing DM have poorer health status at initial visit and a year later. This finding was mostly explained by the differences in their socioeconomic, psychosocial, comorbidities and disease characteristics. Patients with diabetes and PAD experience similar improvement in health status with invasive PAD treatment as their non-diabetic counterparts. PAD patients with DM should be offered similar treatment options as those without DM as they have similar health status gains with time
Cataloging source
UMK
http://library.link/vocab/creatorDate
1988-
http://library.link/vocab/creatorName
Patel, Krishna Kaushik
Degree
M.S.
Dissertation note
(School of Medicine).
Dissertation year
2018.
Granting institution
University of Missouri-Kansas City,
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Smolderen, Kim G.
http://library.link/vocab/subjectName
  • Arteries
  • Diabetes
  • Peripheral Arterial Disease
  • Diabetes Mellitus
Label
Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease : Insights from the PORTRAIT Registry, by Krishna Kaushik Patel
Instantiates
Publication
Copyright
Note
  • "A thesis in Bioinformatics."
  • Advisor: Kim Smolderen
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 47-49)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type MARC source
rdacontent
Contents
Introduction -- Methodology -- Results -- Discussion -- Appendix
Control code
1260163886
Dimensions
unknown
Extent
1 online resource (50 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)1260163886
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web
Label
Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease : Insights from the PORTRAIT Registry, by Krishna Kaushik Patel
Publication
Copyright
Note
  • "A thesis in Bioinformatics."
  • Advisor: Kim Smolderen
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 47-49)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type MARC source
rdacontent
Contents
Introduction -- Methodology -- Results -- Discussion -- Appendix
Control code
1260163886
Dimensions
unknown
Extent
1 online resource (50 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)1260163886
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web

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