Coverart for item
The Resource Improving the utility and translation of animal models for nervous system disorders : workshop summary, Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies

Improving the utility and translation of animal models for nervous system disorders : workshop summary, Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies

Label
Improving the utility and translation of animal models for nervous system disorders : workshop summary
Title
Improving the utility and translation of animal models for nervous system disorders
Title remainder
workshop summary
Statement of responsibility
Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Creator
Contributor
Author
Sponsoring body
Subject
Genre
Language
eng
Summary
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected
Cataloging source
NLM
http://library.link/vocab/creatorDate
1975-
http://library.link/vocab/creatorName
Pankevich, Diana E.
Dewey number
616.02/7
Funding information
This project was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; CeNeRx Biopharma; the Department of Health and Human Services' National Institutes of Health (NIH, Contract No. N01-OD-4-2139) through the National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; Department of Veterans Affairs; Eli Lilly and Company; Fast Forward, LLC; Foundation for the National Institutes of Health; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; the National Science Foundation (Contract No. OIA-0753701); One Mind for Research; Pfizer Inc.; the Society for Neuroscience; and Wellcome Trust.
Illustrations
illustrations
Index
no index present
LC call number
RC347
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
WL 140
http://library.link/vocab/relatedWorkOrContributorDate
2012
http://library.link/vocab/relatedWorkOrContributorName
  • Wizemann, Theresa M.
  • Altevogt, Bruce M.
  • Institute of Medicine (U.S.)
  • Workshop "Improving Translation of Animal Models for Nervous System Disorders"
http://library.link/vocab/subjectName
  • Nervous system
  • Animal models in research
  • Nervous System Diseases
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical
  • Models, Animal
  • Research Design
  • Translational Medical Research
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Animal models in research
  • Nervous system
Label
Improving the utility and translation of animal models for nervous system disorders : workshop summary, Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Instantiates
Publication
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics
Control code
827359047
Dimensions
unknown
Extent
1 online resource (1 PDF file (xi, 97 pages))
Form of item
online
Isbn
9780309266338
Lccn
2013427677
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)827359047
Label
Improving the utility and translation of animal models for nervous system disorders : workshop summary, Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Publication
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics
Control code
827359047
Dimensions
unknown
Extent
1 online resource (1 PDF file (xi, 97 pages))
Form of item
online
Isbn
9780309266338
Lccn
2013427677
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)827359047

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