Coverart for item
The Resource Ion channels and disease : channelopathies, Frances M. Ashcroft

Ion channels and disease : channelopathies, Frances M. Ashcroft

Label
Ion channels and disease : channelopathies
Title
Ion channels and disease
Title remainder
channelopathies
Statement of responsibility
Frances M. Ashcroft
Creator
Subject
Genre
Language
eng
Summary
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Member of
Action
digitized
Cataloging source
OPELS
http://library.link/vocab/creatorName
Ashcroft, Frances M
Dewey number
616.07
Illustrations
illustrations
Index
index present
LC call number
RB112.5
LC item number
.A83 2000eb
Literary form
non fiction
NAL call number
QH603.I54
NAL item number
A84 2000
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 1999 K-445
  • QH 603.I54
http://library.link/vocab/subjectName
  • Ion channels
  • Pathology, Molecular
  • Ion Channels
  • Genetic Diseases, Inborn
  • Membrane Proteins
  • Metabolism, Inborn Errors
  • MEDICAL
  • MEDICAL
  • Ion channels
  • Cell control mechanisms
  • Ion channels
  • Pathology, Molecular
  • Chronische Krankheit
  • Funktionsstörung
  • Ionenkanal
  • Kanalopathieën
  • Pathologie moléculaire
  • Canaux ioniques
  • Membrane cellulaire
Label
Ion channels and disease : channelopathies, Frances M. Ashcroft
Instantiates
Publication
Bibliography note
Includes bibliographical references (pages 419-464) and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index
Control code
162128696
Dimensions
unknown
Extent
1 online resource (xxi, 481 pages)
Form of item
online
Isbn
9780080535210
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
77892:77892
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)162128696
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Ion channels and disease : channelopathies, Frances M. Ashcroft
Publication
Bibliography note
Includes bibliographical references (pages 419-464) and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index
Control code
162128696
Dimensions
unknown
Extent
1 online resource (xxi, 481 pages)
Form of item
online
Isbn
9780080535210
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
77892:77892
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)162128696
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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