The Resource Ion channels and disease : channelopathies, Frances M. Ashcroft
Ion channels and disease : channelopathies, Frances M. Ashcroft
Resource Information
The item Ion channels and disease : channelopathies, Frances M. Ashcroft represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item Ion channels and disease : channelopathies, Frances M. Ashcroft represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from 1 library branch.
- Summary
- Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
- Language
- eng
- Extent
- 1 online resource (xxi, 481 pages)
- Contents
-
- Preface.
- Introduction.
- From Gene to Protein.
- How Channels Work.
- Methods for Studying Ion Channels.
- Voltage-Gated Na<sup>+</sup> Channels.
- Voltage-Gated K<sup>+</sup> Channels.
- Ca-Activated K<sup>+</sup> Channels.
- Inward Rectifier K<sup>+</sup> Channels.
- Voltage-Gated Ca<sup>2+</sup> Channels.
- Voltage-Gated Cl<sup>-</sup> Channels.
- Cyclic Nucleotide-Gated Channels.
- CFTR.
- Epithelia Na<sup>+</sup> Channels.
- Ligand-Gated Ca<sup>2+</sup> Channels.
- ACh Receptor Channels.
- Glutamate Receptor Channels.
- Glycine Receptors.
- GABA Receptors.
- Water Channels.
- Gap Junction Channels.
- Antibodies to Ion Channels.
- Ion Channels in Viruses.
- Ion Channels as Lethal Agents.
- A Miscellany of Ion Channels.
- The Last Word.
- References.
- Subject Index
- Isbn
- 9781435601123
- Label
- Ion channels and disease : channelopathies
- Title
- Ion channels and disease
- Title remainder
- channelopathies
- Statement of responsibility
- Frances M. Ashcroft
- Subject
-
- Canaux ioniques
- Cell control mechanisms
- Chronische Krankheit
- Electronic books
- Funktionsstörung
- Genetic Diseases, Inborn -- physiopathology
- Ion Channels -- physiology
- Ion channels
- Ion channels
- Ion channels
- Kanalopathieën
- MEDICAL -- Pathology
- MEDICAL -- Pathophysiology
- Membrane Proteins -- physiology
- Membrane cellulaire
- Metabolism, Inborn Errors -- physiopathology
- Pathologie moléculaire
- Pathology, Molecular
- Pathology, Molecular
- Ionenkanal
- Language
- eng
- Summary
- Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
- Action
- digitized
- Cataloging source
- OPELS
- http://library.link/vocab/creatorName
- Ashcroft, Frances M
- Dewey number
- 616.07
- Illustrations
- illustrations
- Index
- index present
- LC call number
- RB112.5
- LC item number
- .A83 2000eb
- Literary form
- non fiction
- NAL call number
- QH603.I54
- NAL item number
- A84 2000
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
-
- 1999 K-445
- QH 603.I54
- http://library.link/vocab/subjectName
-
- Ion channels
- Pathology, Molecular
- Ion Channels
- Genetic Diseases, Inborn
- Membrane Proteins
- Metabolism, Inborn Errors
- MEDICAL
- MEDICAL
- Ion channels
- Cell control mechanisms
- Ion channels
- Pathology, Molecular
- Chronische Krankheit
- Funktionsstörung
- Ionenkanal
- Kanalopathieën
- Pathologie moléculaire
- Canaux ioniques
- Membrane cellulaire
- Label
- Ion channels and disease : channelopathies, Frances M. Ashcroft
- Bibliography note
- Includes bibliographical references (pages 419-464) and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index
- Control code
- 162128696
- Dimensions
- unknown
- Extent
- 1 online resource (xxi, 481 pages)
- Form of item
- online
- Isbn
- 9781435601123
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations (some color)
- http://library.link/vocab/ext/overdrive/overdriveId
- 77892:77892
- Reproduction note
- Electronic reproduction.
- Specific material designation
- remote
- System control number
- (OCoLC)162128696
- System details
- Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
- Label
- Ion channels and disease : channelopathies, Frances M. Ashcroft
- Bibliography note
- Includes bibliographical references (pages 419-464) and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index
- Control code
- 162128696
- Dimensions
- unknown
- Extent
- 1 online resource (xxi, 481 pages)
- Form of item
- online
- Isbn
- 9781435601123
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations (some color)
- http://library.link/vocab/ext/overdrive/overdriveId
- 77892:77892
- Reproduction note
- Electronic reproduction.
- Specific material designation
- remote
- System control number
- (OCoLC)162128696
- System details
- Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Subject
- Canaux ioniques
- Cell control mechanisms
- Chronische Krankheit
- Electronic books
- Funktionsstörung
- Genetic Diseases, Inborn -- physiopathology
- Ion Channels -- physiology
- Ion channels
- Ion channels
- Ion channels
- Kanalopathieën
- MEDICAL -- Pathology
- MEDICAL -- Pathophysiology
- Membrane Proteins -- physiology
- Membrane cellulaire
- Metabolism, Inborn Errors -- physiopathology
- Pathologie moléculaire
- Pathology, Molecular
- Pathology, Molecular
- Ionenkanal
Genre
Member of
Library Links
Embed
Settings
Select options that apply then copy and paste the RDF/HTML data fragment to include in your application
Embed this data in a secure (HTTPS) page:
Layout options:
Include data citation:
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Ion-channels-and-disease--channelopathies/ajfgIuQoU_U/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Ion-channels-and-disease--channelopathies/ajfgIuQoU_U/">Ion channels and disease : channelopathies, Frances M. Ashcroft</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
Note: Adjust the width and height settings defined in the RDF/HTML code fragment to best match your requirements
Preview
Cite Data - Experimental
Data Citation of the Item Ion channels and disease : channelopathies, Frances M. Ashcroft
Copy and paste the following RDF/HTML data fragment to cite this resource
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Ion-channels-and-disease--channelopathies/ajfgIuQoU_U/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Ion-channels-and-disease--channelopathies/ajfgIuQoU_U/">Ion channels and disease : channelopathies, Frances M. Ashcroft</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
