The Resource Ion transport modeling for retinal rod photoreceptor cells, by Xiaozhen Wang

Ion transport modeling for retinal rod photoreceptor cells, by Xiaozhen Wang

Label
Ion transport modeling for retinal rod photoreceptor cells
Title
Ion transport modeling for retinal rod photoreceptor cells
Statement of responsibility
by Xiaozhen Wang
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
In this study, a mathematical model is developed to describe the ion transport activities associated with the response of rod photoreceptor to light stimulus. In the model, the cell body is modeled as two capacitors connected via the connecting cilium. Roles of different ion channels during a photoreceptor light response are analyzed, and the relations between changes in ion concentration and response currents are assessed. Methods are developed for computing the membrane potential from ion concentrations and relating the material and electrical resistances. The steady state under different conditions can be uniquely defined with only three measured values. The model can effectively describe the rod photoreceptor response to different light stimuli. Model simulation of the a-wave for progressive narrowing of the connecting cilium corresponds well with published literature on hereditary retinal degeneration of Abyssinian cats. Reductions in amplitude and changes in the a-wave waveform are observed in different stages of the disease. Changes in the receptor response amplitude may not be measurable till the conductance of the connecting cilium is reduced to a comparable magnitude of the ion channels. The model can provide quantitative information of ionic activities, changes in ion concentrations and membrane voltage in the outer segment and the inner compartment. The ionic environment is found to be different between the outer segment and the inner compartment. During receptor response, changes in the outer segment appear to be stronger and quicker than those in the inner compartment. Reductions in the connecting cilium transport can reset the dark resting state
Cataloging source
MUU
http://library.link/vocab/creatorName
Wang, Xiaozhen
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2010.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1958-
http://library.link/vocab/relatedWorkOrContributorName
Tan, Jinglu
Label
Ion transport modeling for retinal rod photoreceptor cells, by Xiaozhen Wang
Instantiates
Publication
Copyright
Note
  • "July 2010."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Jinglu Tan
Bibliography note
Includes bibliographical references (pages 87-91)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
900726647
Extent
1 online resource (x, 91 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)900726647
Label
Ion transport modeling for retinal rod photoreceptor cells, by Xiaozhen Wang
Publication
Copyright
Note
  • "July 2010."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Jinglu Tan
Bibliography note
Includes bibliographical references (pages 87-91)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
900726647
Extent
1 online resource (x, 91 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)900726647

Library Locations

  • St. Louis Mercantile LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • Thomas Jefferson LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • University ArchivesBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • Ward E Barnes Education LibraryBorrow it
    8001 Natural Bridge Rd, St. Louis, MO, 63121, US
    38.707079 -90.311355
Processing Feedback ...