The Resource Micro-imaging characterization of mouse models of metastasis, by Christopher Todd Winkelmann, (electronic resource)

Micro-imaging characterization of mouse models of metastasis, by Christopher Todd Winkelmann, (electronic resource)

Label
Micro-imaging characterization of mouse models of metastasis
Title
Micro-imaging characterization of mouse models of metastasis
Statement of responsibility
by Christopher Todd Winkelmann
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores the use of three micro-imaging modalities, including Micro-CT, PET and SPECT, to characterize tumor anatomical progression, metabolism, bone lesion remodeling, and/or gastrin releasing peptide receptor expression in mouse models of metastatic melanoma and prostate and breast cancer bone metastasis. Micro-CT was shown to provide excellent anatomical information about tumor progression in several different tissues including lung, bone, and subcutaneous tissues. Micro-PET imaging demonstrated increased tumor metabolism in melanoma tumors, but was not able to discern bone remodeling in breast cancer bone lesions. Micro-SPECT imaging demonstrated gastrin-releasing peptide receptor expression in a prostate cancer bone metastasis model. The results from this work demonstrate the ability of micro-imaging technologies to non-invasively probe mouse models of disease to obtain information in vivo that is not possible with ex vivo experimental techniques
Cataloging source
MMU
http://library.link/vocab/creatorDate
1971-
http://library.link/vocab/creatorName
Winkelmann, Christopher Todd
Degree
Ph. D.
Dissertation year
2005.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1958-
http://library.link/vocab/relatedWorkOrContributorName
Hoffman, Timothy Joseph
http://library.link/vocab/subjectName
  • Cancer
  • Metastasis
  • Tomography, Emission
  • Single-photon emission computed tomography
  • Tomography
Target audience
specialized
Label
Micro-imaging characterization of mouse models of metastasis, by Christopher Todd Winkelmann, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
  • "December 2005"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
71320987
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campuses of the University of Missouri
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System details
Mode of access: World Wide Web
Label
Micro-imaging characterization of mouse models of metastasis, by Christopher Todd Winkelmann, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
  • "December 2005"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
71320987
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campuses of the University of Missouri
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System details
Mode of access: World Wide Web

Library Locations

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      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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