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Microfluidics for medical applications, edited by Albert Berg and Loes Segerink

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The item Microfluidics for medical applications, edited by Albert Berg and Loes Segerink represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
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Editor

Contributor

Language: eng

Work

Publication

Cambridge, UK, Royal Society of Chemistry, 2015

Extent: 1 online resource (xvii, 303 pages)

Contents

1.2.1.
Co-axial Flow Systems
1.3.
Wetspinning
1.4.
Meltspinning (Extrusion)
1.5.
Electrospinning
1.6.
Conclusions
Machine generated contents note:
Acknowledgements
References
ch. 2
Kidney on a Chip
Kahp-Yang Suh
2.1.
Introduction
2.2.
Kidney Structure and Function
2.3.
ch. 1
Mimicking Kidney Environment
2.3.1.
Extracellular Matrix
2.3.2.
Mechanical Stimulation
2.3.3.
Various Kidney Cells
2.3.4.
Extracellular Environment
2.4.
Microtechnologies in the Fabrication of Fibers for Tissue Engineering
Kidney on a Chip
2.4.1.
Microfluidic Approach for Kidney on a Chip
2.4.2.
Fabrication of Kidney on a Chip
2.4.3.
Various Kidney Chips
2.5.
Future Opportunities and Challenges
References
Ali Khademhosseini
ch. 3
Blood-brain Barrier (BBB): An Overview of the Research of the Blood-brain Barrier Using Microfluidic Devices
Albert van den Berg
1.1.
Introduction
1.2.
Fiber Formation Techniques
3.2.3.
Multidrug Resistance
3.2.4.
Neurodegenerative Diseases -- Loss of BBB Function
3.3.
Modeling the BBB in Vitro
3.3.1.
Microfluidic in Vitro Models of the BBB: the "BBB-on-Chip"
3.3.2.
Cellular Engineering
3.1.
3.3.3.
Biochemical Engineering
3.3.4.
Biophysical Engineering
3.4.
Measurement Techniques
3.4.1.
Transendothelial Electrical Resistance
3.4.2.
Permeability
Introduction
3.4.3.
Fluorescence Microscopy
3.5.
Conclusion and Future Prospects
Acknowledgements
References
ch. 4
The Use of Microfluidic-based Neuronal Cell Cultures to Study Alzheimer's Disease
Philippe Renaud
4.1.
3.2.
Alzheimer's Disease -- Increased Mortality Rates and Still Incurable
4.2.
Unknowns of Alzheimer's Disease
4.2.1.
Molecular Key Players of AD
4.2.2.
From Molecules to Neuronal Networks
4.3.
Why Microsystems May Be a Key in Understanding the Propagation of AD
4.3.1.
Blood-brain Barrier
Requirements for in Vitro Studies on AD Progression
3.2.1.
Neurovascular Unit
3.2.2.
Transport
4.5.
Questions that May Be Addressed by Micro-controlled Cultures
References
ch. 5
Microbubbles for Medical Applications
Michel Versluis
5.1.
Introduction
5.1.1.
Microbubbles for Imaging
4.3.2.
5.1.2.
Microbubbles for Therapy
5.1.3.
Microbubbles for Cleaning
5.2.
Microbubble Basics
5.2.1.
Microbubble Dynamics
5.3.
Microbubble Stability
Establishing Ordered Neuronal Cultures with Microfluidics
5.4.
Microbubble Formation
5.5.
Microbubble Modeling and Characterization
5.5.1.
Optical Characterization
5.5.2.
Sorting Techniques
5.5.3.
Acoustical Characterization
4.4.
5.6.
Conclusions
Acknowledgements
References
ch. 6
Magnetic Particle Actuation in Stationary Microfluidics for Integrated Lab-on-Chip Biosensors
Menno W.J. Prins
6.1.
Introduction
6.2.
Micro-devices-based in Vitro Alzheimer Models
Capture of Analyte Using Magnetic Particles
4.4.1.
First Microtechnology-based Experimental Models
4.4.2.
Requirements of Future Micro-device-based Studies
6.3.2.
Agglutination Assay with Magnetic Particles
6.3.3.
Surface-binding Assay with Magnetic Particles as Labels
6.3.4.
Magnetic Stringency
6.4.
Integration of Magnetic Actuation Processes
6.5.
Conclusions
6.2.1.
Acknowledgements
References
ch. 7
Microfluidics for Assisted Reproductive Technologies
Shuichi Takayama
7.1.
Introduction
7.2.
Gamete Manipulations
7.2.1.
The Analyte Capture Process
Male Gamete Sorting
7.2.2.
Female Gamete Quality Assessment
7.3.
In Vitro Fertilization
7.4.
Cryopreservation
7.5.
Embryo Culture
7.6.
6.2.2.
Embryo Analysis
7.7.
Conclusion
References
ch. 8
Microfluidic Diagnostics for Low-resource Settings: Improving Global Health without a Power Cord
Paul Yager
8.1.
Introduction: Need for Diagnostics in Low-resource Settings
8.1.1.
Analyte Capture Using Magnetic Particles in a Static Fluid
Importance of Diagnostic Testing
8.1.2.
Limitations in Low-resource Settings
6.3.
Analyte Detection
6.3.1.
Magnetic Particles as Carriers
8.2.3.
Counterfeit Drug Testing
8.2.4.
Environmental Testing
8.3.
Overview of Microfluidic Diagnostics for Use at the Point of Care
8.3.1.
Channel-based Microfluidics
8.3.2.
Paper-based Microfluidics
8.1.3.
8.4.
Enabling All Aspects of Diagnostic Testing in Low-resource Settings: Examples of and Opportunities for Microfluidics (Channel-based and Paper-based)
8.4.1.
Transportation and Storage of Devices in Low-resource Settings
8.4.2.
Specimen Collection
8.4.3.
Sample Preparation
8.4.4.
Running the Assay
Scope of Chapter
8.4.5.
Signal Read-out
8.4.6.
Data Integration into Health Systems
8.4.7.
Disposal
8.5.
Conclusions
References
ch. 9
8.2.
Isolation and Characterization of Circulating Tumor Cells
Leon W.M.M. Terstappen
9.1.
Introduction
9.2.
CTC Definition in CellSearch System
9.3.
Clinical Relevance of CTCs
9.4.
Identification of Treatment Targets on CTCs
Types of Diagnostic Testing Needed in Low-resource Settings
8.2.1.
Diagnosing Disease
8.2.2.
Monitoring Disease
9.6.3.
Microfluidic Devices to Isolate CTCs Based on Physical as well as Immunological Properties
9.6.4.
Characterization of CTCs in Microfluidic Devices
9.7.
Summary and Outlook
References
ch. 10
Microfluidic Impedance Cytometry for Blood Cell Analysis
Daniel Spencer
9.5.
10.1.
Introduction
10.2.
The Full Blood Count
10.2.1.
Clinical Diagnosis and the Full Blood Count
10.2.2.
Commercial FBC Devices
10.3.
Microfluidic Impedance Cytometry (MIC)
Technologies for CTC Enumeration
10.3.1.
Measurement Principle
10.3.2.
Behavior of Cells in AC fields
10.3.3.
Sizing Particles
10.3.4.
Cell Membrane Capacitance Measurements
10.3.5.
Microfluidic FBC Chip
9.6.
10.3.6.
Accuracy and Resolution
10.3.7.
Antibody Detection
10.4.
Further Applications of MIC
Isolation and Identification of CTCs in Microfluidic Devices
9.6.1.
Microfluidic Devices for CTC Isolation Based on Physical Properties
9.6.2.
Microfluidic Devices to Isolate CTCs Based on Immunological Properties
10.5.
Future Challenges
References
ch. 11
Routine Clinical Laboratory Diagnostics Using Point of Care or Lab on a Chip Technology
Istvan Vermes
11.1.
Introduction
11.2.
Point-of-care Testing
10.4.1.
11.2.1.
Categorization of POCT Devices
11.2.2.
Role of POCT in Laboratory Medicine
11.3.
Glucometers
11.3.1.
The WHO and ADA Criteria of Diabetes
11.3.2.
Plasma Glucose or Blood Glucose
Cell Counting and Viability
11.3.3.
Glucometers in Medical Practice
11.3.4.
Glucometers in Gestational Diabetes
11.3.5.
Continuous Glucose Monitoring
11.4.
i-STAT: a Multi-parameter Unit-use POCT Instrument
11.4.1.
Clinical Chemistry
10.4.2.
11.4.2.
Cardiac Markers
11.4.3.
Hematology
11.4.4.
Clinical Use and Performance
11.5.
Conclusions
References
ch. 12
Parasitized Cells
Medimate Minilab, a Microchip Capillary Electrophoresis Self-test Platform
Jan C.T. Eijkel
12.1.
Introduction
10.4.3.
Tumor Cells and Stem Cell Morphology
10.4.4.
High-frequency Measurements
12.3.
A Lithium Self-test for Patients with Manic Depressive Illness
12.4.
Validation Method
12.4.1.
Applied Guidelines
12.4.2.
Acceptance Criteria
12.4.3.
Sample Availability, Preparation, and other Considerations
12.2.
12.5.
Validation Results
12.5.1.
Reproducibility
12.5.2.
Linearity
12.5.3.
Method Comparison
12.5.4.
Home Test
Microfluidic Capillary Electrophoresis as a Self-test Platform
12.5.5.
Other Study Results
12.5.6.
Final Evaluation
12.6.
Platform Potential
12.6.1.
Current Platform Capabilities
12.6.2.
Future Possibilities and Limitations
12.2.1.
12.7.
Conclusions
Acknowledgements
References
Conducting a Measurement
12.2.2.
Measurement Process
12.2.3.
From Research Technology to Self-test Platform

Isbn: 9781849737593

Instance

Label: Microfluidics for medical applications

Title: Microfluidics for medical applications

Statement of responsibility: edited by Albert Berg and Loes Segerink

Electronic books

Language: eng

Member of

RSC nanoscience & nanotechnology, 36

Cataloging source: COO

Dewey number: 532.05

Illustrations: illustrations

Index: index present

LC call number: TJ853.4.M53

Literary form: non fiction

Nature of contents

dictionaries
bibliography

NLM call number: QT 34

http://library.link/vocab/relatedWorkOrContributorName

Berg, A. van den
Segerink, Loes

Series statement: RSC nanoscience & nanotechnology,

Series volume: no. 36

http://library.link/vocab/subjectName

Microfluidics
Medical technology
Microbubbles
Microfluidics
Chemistry
Clinical & internal medicine
TECHNOLOGY & ENGINEERING
Medical technology
Microfluidics

Label: Microfluidics for medical applications, edited by Albert Berg and Loes Segerink

Instantiates

Microfluidics for medical applications

Publication

Cambridge, UK, Royal Society of Chemistry, 2015

Bibliography note: Includes bibliographical references and index

Carrier category: online resource

Carrier category code

Carrier MARC source: rdacarrier

Content category: text

Content type code

Content type MARC source: rdacontent

Contents

1.2.1.
Co-axial Flow Systems
1.3.
Wetspinning
1.4.
Meltspinning (Extrusion)
1.5.
Electrospinning
1.6.
Conclusions
Machine generated contents note:
Acknowledgements
References
ch. 2
Kidney on a Chip
Kahp-Yang Suh
2.1.
Introduction
2.2.
Kidney Structure and Function
2.3.
ch. 1
Mimicking Kidney Environment
2.3.1.
Extracellular Matrix
2.3.2.
Mechanical Stimulation
2.3.3.
Various Kidney Cells
2.3.4.
Extracellular Environment
2.4.
Microtechnologies in the Fabrication of Fibers for Tissue Engineering
Kidney on a Chip
2.4.1.
Microfluidic Approach for Kidney on a Chip
2.4.2.
Fabrication of Kidney on a Chip
2.4.3.
Various Kidney Chips
2.5.
Future Opportunities and Challenges
References
Ali Khademhosseini
ch. 3
Blood-brain Barrier (BBB): An Overview of the Research of the Blood-brain Barrier Using Microfluidic Devices
Albert van den Berg
1.1.
Introduction
1.2.
Fiber Formation Techniques
3.2.3.
Multidrug Resistance
3.2.4.
Neurodegenerative Diseases -- Loss of BBB Function
3.3.
Modeling the BBB in Vitro
3.3.1.
Microfluidic in Vitro Models of the BBB: the "BBB-on-Chip"
3.3.2.
Cellular Engineering
3.1.
3.3.3.
Biochemical Engineering
3.3.4.
Biophysical Engineering
3.4.
Measurement Techniques
3.4.1.
Transendothelial Electrical Resistance
3.4.2.
Permeability
Introduction
3.4.3.
Fluorescence Microscopy
3.5.
Conclusion and Future Prospects
Acknowledgements
References
ch. 4
The Use of Microfluidic-based Neuronal Cell Cultures to Study Alzheimer's Disease
Philippe Renaud
4.1.
3.2.
Alzheimer's Disease -- Increased Mortality Rates and Still Incurable
4.2.
Unknowns of Alzheimer's Disease
4.2.1.
Molecular Key Players of AD
4.2.2.
From Molecules to Neuronal Networks
4.3.
Why Microsystems May Be a Key in Understanding the Propagation of AD
4.3.1.
Blood-brain Barrier
Requirements for in Vitro Studies on AD Progression
3.2.1.
Neurovascular Unit
3.2.2.
Transport
4.5.
Questions that May Be Addressed by Micro-controlled Cultures
References
ch. 5
Microbubbles for Medical Applications
Michel Versluis
5.1.
Introduction
5.1.1.
Microbubbles for Imaging
4.3.2.
5.1.2.
Microbubbles for Therapy
5.1.3.
Microbubbles for Cleaning
5.2.
Microbubble Basics
5.2.1.
Microbubble Dynamics
5.3.
Microbubble Stability
Establishing Ordered Neuronal Cultures with Microfluidics
5.4.
Microbubble Formation
5.5.
Microbubble Modeling and Characterization
5.5.1.
Optical Characterization
5.5.2.
Sorting Techniques
5.5.3.
Acoustical Characterization
4.4.
5.6.
Conclusions
Acknowledgements
References
ch. 6
Magnetic Particle Actuation in Stationary Microfluidics for Integrated Lab-on-Chip Biosensors
Menno W.J. Prins
6.1.
Introduction
6.2.
Micro-devices-based in Vitro Alzheimer Models
Capture of Analyte Using Magnetic Particles
4.4.1.
First Microtechnology-based Experimental Models
4.4.2.
Requirements of Future Micro-device-based Studies
6.3.2.
Agglutination Assay with Magnetic Particles
6.3.3.
Surface-binding Assay with Magnetic Particles as Labels
6.3.4.
Magnetic Stringency
6.4.
Integration of Magnetic Actuation Processes
6.5.
Conclusions
6.2.1.
Acknowledgements
References
ch. 7
Microfluidics for Assisted Reproductive Technologies
Shuichi Takayama
7.1.
Introduction
7.2.
Gamete Manipulations
7.2.1.
The Analyte Capture Process
Male Gamete Sorting
7.2.2.
Female Gamete Quality Assessment
7.3.
In Vitro Fertilization
7.4.
Cryopreservation
7.5.
Embryo Culture
7.6.
6.2.2.
Embryo Analysis
7.7.
Conclusion
References
ch. 8
Microfluidic Diagnostics for Low-resource Settings: Improving Global Health without a Power Cord
Paul Yager
8.1.
Introduction: Need for Diagnostics in Low-resource Settings
8.1.1.
Analyte Capture Using Magnetic Particles in a Static Fluid
Importance of Diagnostic Testing
8.1.2.
Limitations in Low-resource Settings
6.3.
Analyte Detection
6.3.1.
Magnetic Particles as Carriers
8.2.3.
Counterfeit Drug Testing
8.2.4.
Environmental Testing
8.3.
Overview of Microfluidic Diagnostics for Use at the Point of Care
8.3.1.
Channel-based Microfluidics
8.3.2.
Paper-based Microfluidics
8.1.3.
8.4.
Enabling All Aspects of Diagnostic Testing in Low-resource Settings: Examples of and Opportunities for Microfluidics (Channel-based and Paper-based)
8.4.1.
Transportation and Storage of Devices in Low-resource Settings
8.4.2.
Specimen Collection
8.4.3.
Sample Preparation
8.4.4.
Running the Assay
Scope of Chapter
8.4.5.
Signal Read-out
8.4.6.
Data Integration into Health Systems
8.4.7.
Disposal
8.5.
Conclusions
References
ch. 9
8.2.
Isolation and Characterization of Circulating Tumor Cells
Leon W.M.M. Terstappen
9.1.
Introduction
9.2.
CTC Definition in CellSearch System
9.3.
Clinical Relevance of CTCs
9.4.
Identification of Treatment Targets on CTCs
Types of Diagnostic Testing Needed in Low-resource Settings
8.2.1.
Diagnosing Disease
8.2.2.
Monitoring Disease
9.6.3.
Microfluidic Devices to Isolate CTCs Based on Physical as well as Immunological Properties
9.6.4.
Characterization of CTCs in Microfluidic Devices
9.7.
Summary and Outlook
References
ch. 10
Microfluidic Impedance Cytometry for Blood Cell Analysis
Daniel Spencer
9.5.
10.1.
Introduction
10.2.
The Full Blood Count
10.2.1.
Clinical Diagnosis and the Full Blood Count
10.2.2.
Commercial FBC Devices
10.3.
Microfluidic Impedance Cytometry (MIC)
Technologies for CTC Enumeration
10.3.1.
Measurement Principle
10.3.2.
Behavior of Cells in AC fields
10.3.3.
Sizing Particles
10.3.4.
Cell Membrane Capacitance Measurements
10.3.5.
Microfluidic FBC Chip
9.6.
10.3.6.
Accuracy and Resolution
10.3.7.
Antibody Detection
10.4.
Further Applications of MIC
Isolation and Identification of CTCs in Microfluidic Devices
9.6.1.
Microfluidic Devices for CTC Isolation Based on Physical Properties
9.6.2.
Microfluidic Devices to Isolate CTCs Based on Immunological Properties
10.5.
Future Challenges
References
ch. 11
Routine Clinical Laboratory Diagnostics Using Point of Care or Lab on a Chip Technology
Istvan Vermes
11.1.
Introduction
11.2.
Point-of-care Testing
10.4.1.
11.2.1.
Categorization of POCT Devices
11.2.2.
Role of POCT in Laboratory Medicine
11.3.
Glucometers
11.3.1.
The WHO and ADA Criteria of Diabetes
11.3.2.
Plasma Glucose or Blood Glucose
Cell Counting and Viability
11.3.3.
Glucometers in Medical Practice
11.3.4.
Glucometers in Gestational Diabetes
11.3.5.
Continuous Glucose Monitoring
11.4.
i-STAT: a Multi-parameter Unit-use POCT Instrument
11.4.1.
Clinical Chemistry
10.4.2.
11.4.2.
Cardiac Markers
11.4.3.
Hematology
11.4.4.
Clinical Use and Performance
11.5.
Conclusions
References
ch. 12
Parasitized Cells
Medimate Minilab, a Microchip Capillary Electrophoresis Self-test Platform
Jan C.T. Eijkel
12.1.
Introduction
10.4.3.
Tumor Cells and Stem Cell Morphology
10.4.4.
High-frequency Measurements
12.3.
A Lithium Self-test for Patients with Manic Depressive Illness
12.4.
Validation Method
12.4.1.
Applied Guidelines
12.4.2.
Acceptance Criteria
12.4.3.
Sample Availability, Preparation, and other Considerations
12.2.
12.5.
Validation Results
12.5.1.
Reproducibility
12.5.2.
Linearity
12.5.3.
Method Comparison
12.5.4.
Home Test
Microfluidic Capillary Electrophoresis as a Self-test Platform
12.5.5.
Other Study Results
12.5.6.
Final Evaluation
12.6.
Platform Potential
12.6.1.
Current Platform Capabilities
12.6.2.
Future Possibilities and Limitations
12.2.1.
12.7.
Conclusions
Acknowledgements
References
Conducting a Measurement
12.2.2.
Measurement Process
12.2.3.
From Research Technology to Self-test Platform

Control code: 898200196

Dimensions: unknown

Extent: 1 online resource (xvii, 303 pages)

Form of item: online

Isbn: 9781849737593

Media category: computer

Media MARC source: rdamedia

Media type code

Other physical details: illustrations

http://library.link/vocab/ext/overdrive/overdriveId: 31789781849737593

Specific material designation: remote

System control number: (OCoLC)898200196

Label: Microfluidics for medical applications, edited by Albert Berg and Loes Segerink

Publication

Cambridge, UK, Royal Society of Chemistry, 2015

Bibliography note: Includes bibliographical references and index

Carrier category: online resource

Carrier category code

Carrier MARC source: rdacarrier

Content category: text

Content type code

Content type MARC source: rdacontent

Contents

1.2.1.
Co-axial Flow Systems
1.3.
Wetspinning
1.4.
Meltspinning (Extrusion)
1.5.
Electrospinning
1.6.
Conclusions
Machine generated contents note:
Acknowledgements
References
ch. 2
Kidney on a Chip
Kahp-Yang Suh
2.1.
Introduction
2.2.
Kidney Structure and Function
2.3.
ch. 1
Mimicking Kidney Environment
2.3.1.
Extracellular Matrix
2.3.2.
Mechanical Stimulation
2.3.3.
Various Kidney Cells
2.3.4.
Extracellular Environment
2.4.
Microtechnologies in the Fabrication of Fibers for Tissue Engineering
Kidney on a Chip
2.4.1.
Microfluidic Approach for Kidney on a Chip
2.4.2.
Fabrication of Kidney on a Chip
2.4.3.
Various Kidney Chips
2.5.
Future Opportunities and Challenges
References
Ali Khademhosseini
ch. 3
Blood-brain Barrier (BBB): An Overview of the Research of the Blood-brain Barrier Using Microfluidic Devices
Albert van den Berg
1.1.
Introduction
1.2.
Fiber Formation Techniques
3.2.3.
Multidrug Resistance
3.2.4.
Neurodegenerative Diseases -- Loss of BBB Function
3.3.
Modeling the BBB in Vitro
3.3.1.
Microfluidic in Vitro Models of the BBB: the "BBB-on-Chip"
3.3.2.
Cellular Engineering
3.1.
3.3.3.
Biochemical Engineering
3.3.4.
Biophysical Engineering
3.4.
Measurement Techniques
3.4.1.
Transendothelial Electrical Resistance
3.4.2.
Permeability
Introduction
3.4.3.
Fluorescence Microscopy
3.5.
Conclusion and Future Prospects
Acknowledgements
References
ch. 4
The Use of Microfluidic-based Neuronal Cell Cultures to Study Alzheimer's Disease
Philippe Renaud
4.1.
3.2.
Alzheimer's Disease -- Increased Mortality Rates and Still Incurable
4.2.
Unknowns of Alzheimer's Disease
4.2.1.
Molecular Key Players of AD
4.2.2.
From Molecules to Neuronal Networks
4.3.
Why Microsystems May Be a Key in Understanding the Propagation of AD
4.3.1.
Blood-brain Barrier
Requirements for in Vitro Studies on AD Progression
3.2.1.
Neurovascular Unit
3.2.2.
Transport
4.5.
Questions that May Be Addressed by Micro-controlled Cultures
References
ch. 5
Microbubbles for Medical Applications
Michel Versluis
5.1.
Introduction
5.1.1.
Microbubbles for Imaging
4.3.2.
5.1.2.
Microbubbles for Therapy
5.1.3.
Microbubbles for Cleaning
5.2.
Microbubble Basics
5.2.1.
Microbubble Dynamics
5.3.
Microbubble Stability
Establishing Ordered Neuronal Cultures with Microfluidics
5.4.
Microbubble Formation
5.5.
Microbubble Modeling and Characterization
5.5.1.
Optical Characterization
5.5.2.
Sorting Techniques
5.5.3.
Acoustical Characterization
4.4.
5.6.
Conclusions
Acknowledgements
References
ch. 6
Magnetic Particle Actuation in Stationary Microfluidics for Integrated Lab-on-Chip Biosensors
Menno W.J. Prins
6.1.
Introduction
6.2.
Micro-devices-based in Vitro Alzheimer Models
Capture of Analyte Using Magnetic Particles
4.4.1.
First Microtechnology-based Experimental Models
4.4.2.
Requirements of Future Micro-device-based Studies
6.3.2.
Agglutination Assay with Magnetic Particles
6.3.3.
Surface-binding Assay with Magnetic Particles as Labels
6.3.4.
Magnetic Stringency
6.4.
Integration of Magnetic Actuation Processes
6.5.
Conclusions
6.2.1.
Acknowledgements
References
ch. 7
Microfluidics for Assisted Reproductive Technologies
Shuichi Takayama
7.1.
Introduction
7.2.
Gamete Manipulations
7.2.1.
The Analyte Capture Process
Male Gamete Sorting
7.2.2.
Female Gamete Quality Assessment
7.3.
In Vitro Fertilization
7.4.
Cryopreservation
7.5.
Embryo Culture
7.6.
6.2.2.
Embryo Analysis
7.7.
Conclusion
References
ch. 8
Microfluidic Diagnostics for Low-resource Settings: Improving Global Health without a Power Cord
Paul Yager
8.1.
Introduction: Need for Diagnostics in Low-resource Settings
8.1.1.
Analyte Capture Using Magnetic Particles in a Static Fluid
Importance of Diagnostic Testing
8.1.2.
Limitations in Low-resource Settings
6.3.
Analyte Detection
6.3.1.
Magnetic Particles as Carriers
8.2.3.
Counterfeit Drug Testing
8.2.4.
Environmental Testing
8.3.
Overview of Microfluidic Diagnostics for Use at the Point of Care
8.3.1.
Channel-based Microfluidics
8.3.2.
Paper-based Microfluidics
8.1.3.
8.4.
Enabling All Aspects of Diagnostic Testing in Low-resource Settings: Examples of and Opportunities for Microfluidics (Channel-based and Paper-based)
8.4.1.
Transportation and Storage of Devices in Low-resource Settings
8.4.2.
Specimen Collection
8.4.3.
Sample Preparation
8.4.4.
Running the Assay
Scope of Chapter
8.4.5.
Signal Read-out
8.4.6.
Data Integration into Health Systems
8.4.7.
Disposal
8.5.
Conclusions
References
ch. 9
8.2.
Isolation and Characterization of Circulating Tumor Cells
Leon W.M.M. Terstappen
9.1.
Introduction
9.2.
CTC Definition in CellSearch System
9.3.
Clinical Relevance of CTCs
9.4.
Identification of Treatment Targets on CTCs
Types of Diagnostic Testing Needed in Low-resource Settings
8.2.1.
Diagnosing Disease
8.2.2.
Monitoring Disease
9.6.3.
Microfluidic Devices to Isolate CTCs Based on Physical as well as Immunological Properties
9.6.4.
Characterization of CTCs in Microfluidic Devices
9.7.
Summary and Outlook
References
ch. 10
Microfluidic Impedance Cytometry for Blood Cell Analysis
Daniel Spencer
9.5.
10.1.
Introduction
10.2.
The Full Blood Count
10.2.1.
Clinical Diagnosis and the Full Blood Count
10.2.2.
Commercial FBC Devices
10.3.
Microfluidic Impedance Cytometry (MIC)
Technologies for CTC Enumeration
10.3.1.
Measurement Principle
10.3.2.
Behavior of Cells in AC fields
10.3.3.
Sizing Particles
10.3.4.
Cell Membrane Capacitance Measurements
10.3.5.
Microfluidic FBC Chip
9.6.
10.3.6.
Accuracy and Resolution
10.3.7.
Antibody Detection
10.4.
Further Applications of MIC
Isolation and Identification of CTCs in Microfluidic Devices
9.6.1.
Microfluidic Devices for CTC Isolation Based on Physical Properties
9.6.2.
Microfluidic Devices to Isolate CTCs Based on Immunological Properties
10.5.
Future Challenges
References
ch. 11
Routine Clinical Laboratory Diagnostics Using Point of Care or Lab on a Chip Technology
Istvan Vermes
11.1.
Introduction
11.2.
Point-of-care Testing
10.4.1.
11.2.1.
Categorization of POCT Devices
11.2.2.
Role of POCT in Laboratory Medicine
11.3.
Glucometers
11.3.1.
The WHO and ADA Criteria of Diabetes
11.3.2.
Plasma Glucose or Blood Glucose
Cell Counting and Viability
11.3.3.
Glucometers in Medical Practice
11.3.4.
Glucometers in Gestational Diabetes
11.3.5.
Continuous Glucose Monitoring
11.4.
i-STAT: a Multi-parameter Unit-use POCT Instrument
11.4.1.
Clinical Chemistry
10.4.2.
11.4.2.
Cardiac Markers
11.4.3.
Hematology
11.4.4.
Clinical Use and Performance
11.5.
Conclusions
References
ch. 12
Parasitized Cells
Medimate Minilab, a Microchip Capillary Electrophoresis Self-test Platform
Jan C.T. Eijkel
12.1.
Introduction
10.4.3.
Tumor Cells and Stem Cell Morphology
10.4.4.
High-frequency Measurements
12.3.
A Lithium Self-test for Patients with Manic Depressive Illness
12.4.
Validation Method
12.4.1.
Applied Guidelines
12.4.2.
Acceptance Criteria
12.4.3.
Sample Availability, Preparation, and other Considerations
12.2.
12.5.
Validation Results
12.5.1.
Reproducibility
12.5.2.
Linearity
12.5.3.
Method Comparison
12.5.4.
Home Test
Microfluidic Capillary Electrophoresis as a Self-test Platform
12.5.5.
Other Study Results
12.5.6.
Final Evaluation
12.6.
Platform Potential
12.6.1.
Current Platform Capabilities
12.6.2.
Future Possibilities and Limitations
12.2.1.
12.7.
Conclusions
Acknowledgements
References
Conducting a Measurement
12.2.2.
Measurement Process
12.2.3.
From Research Technology to Self-test Platform

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