Coverart for item
The Resource New frontiers in chemical biology : enabling drug discovery, [edited by] Mark Bunnage, David Thurston, David Fox

New frontiers in chemical biology : enabling drug discovery, [edited by] Mark Bunnage, David Thurston, David Fox

Label
New frontiers in chemical biology : enabling drug discovery
Title
New frontiers in chemical biology
Title remainder
enabling drug discovery
Statement of responsibility
[edited by] Mark Bunnage, David Thurston, David Fox
Contributor
Subject
Language
eng
Summary
Annotation
Member of
Cataloging source
UKRSC
Dewey number
615/.19
Index
index present
Language note
English
LC call number
RS420
LC item number
.N49 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Bunnage, Mark E
  • Thurston, David E
  • Fox, David
Series statement
RSC drug discovery
Series volume
5
http://library.link/vocab/subjectName
  • Drugs
  • Pharmaceutical chemistry
  • Laboratory Chemicals
  • Chemistry, Pharmaceutical
  • Genetic Phenomena
  • Investigative Techniques
  • Biochemical Phenomena
  • Pharmacological Phenomena
  • Phenomena and Processes
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Specialty Uses of Chemicals
  • Pharmacology
  • Chemistry
  • Chemical Phenomena
  • Physiological Phenomena
  • Chemical Actions and Uses
  • Natural Science Disciplines
  • Biological Science Disciplines
  • Chemicals and Drugs
  • Disciplines and Occupations
  • Structure-Activity Relationship
  • Small Molecule Libraries
  • Drug Discovery
  • Genetic Structures
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Drugs
  • Pharmaceutical chemistry
Summary expansion
Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides. Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenges expressed above. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules involved in many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is a key discipline within 21st century drug discovery and the purpose of this book is to highlight the most important developments. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic. The individual chapters cover crucial areas including chemical proteomics, chemical genetics, post-translational modifications, epigenetics, RNA interference, PROTACS, antibody-drug conjugates, and chemologics
Label
New frontiers in chemical biology : enabling drug discovery, [edited by] Mark Bunnage, David Thurston, David Fox
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The chemical genetic approach : the interrogation of biological mechanisms with small molecule probes / Martin Fisher and Adam Nelson -- Applications for activity-based probes in drug discovery / L.E. Edgington and M. Bogyo -- Targeted intracellular protein degradation as a potential therapeutic strategy / A.R. Schneekloth and C.M. Crews -- Chemical biology of stem cell modulation / Stephen G. Davies and Angela J. Russell -- Chemical biology of histone modifications / Nathan R. Rose, Christopher J. Schofield and Tom D. Heightman -- Chemologics / Lyn H. Jones -- Antibody-drug conjugates in oncology / Philip R. Hamann and Russell G. Dushin -- Drug discovery by DNA-encoded libraries / Yizhou Li, Zheng Zhu and Xiaoyu Li
Control code
642690095
Dimensions
unknown
Extent
1 online resource
Form of item
online
Isbn
9781849732178
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1039/9781849732178
http://library.link/vocab/ext/overdrive/overdriveId
t3317
Specific material designation
remote
System control number
(OCoLC)642690095
Label
New frontiers in chemical biology : enabling drug discovery, [edited by] Mark Bunnage, David Thurston, David Fox
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The chemical genetic approach : the interrogation of biological mechanisms with small molecule probes / Martin Fisher and Adam Nelson -- Applications for activity-based probes in drug discovery / L.E. Edgington and M. Bogyo -- Targeted intracellular protein degradation as a potential therapeutic strategy / A.R. Schneekloth and C.M. Crews -- Chemical biology of stem cell modulation / Stephen G. Davies and Angela J. Russell -- Chemical biology of histone modifications / Nathan R. Rose, Christopher J. Schofield and Tom D. Heightman -- Chemologics / Lyn H. Jones -- Antibody-drug conjugates in oncology / Philip R. Hamann and Russell G. Dushin -- Drug discovery by DNA-encoded libraries / Yizhou Li, Zheng Zhu and Xiaoyu Li
Control code
642690095
Dimensions
unknown
Extent
1 online resource
Form of item
online
Isbn
9781849732178
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1039/9781849732178
http://library.link/vocab/ext/overdrive/overdriveId
t3317
Specific material designation
remote
System control number
(OCoLC)642690095

Library Locations

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      38.710138 -90.311107
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