The Resource Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration, by Jongwon Park

Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration, by Jongwon Park

Label
Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration
Title
Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration
Statement of responsibility
by Jongwon Park
Creator
Author
Subject
Genre
Language
eng
Summary
"The design, fabrication and characterization of optofluidic biosensor systems for quantitative oxygen imaging with a color charge-coupled device (CCD) camera as well as on-chip self-calibration of sensors utilizing gas bubbles was investigated. This dissertation was prepared in publication format. The first and second papers demonstrate that color imaging devices can be used in quantitative chemical analysis. The final paper explores the feasibility of using electrolytically generated bubbles for a novel functionality of reagentless, on-chip, in situ calibration of optical biosensors. Work in the first paper includes the use of a color CCD camera for fluorescence intensity imaging. This involves extracting the red color element to determine the dissolved oxygen content from the color image of a sample. The linearity and sensitivity of oxygen detection based on the red intensity analysis was improved to those of spectrometric measurement and total color intensity analysis. In the second paper, the color extraction technique used in the dissolved oxygen sensor was extended to gaseous oxygen detection to eliminate the need of optical filters and replace the blue light emitting diode (LED) excitation source with a general broad-band white LED. This new method has potential applications in multi-analyte monitoring and simultaneous structural/functional imaging of biological samples with a single broad-band light source. In the final paper, a double-layered optofluidic system was developed to demonstrate on-chip, self-calibration of dissolved oxygen sensor. A multilayers of dry film resist was used for preparing a 3-D fluidic structure. A thin black polydimethylsiloxane membrane was used for oxygen diffusion and optical isolation. The sensor calibration result with the on-chip bubble was shown to be in good agreement with that of standard calibrants"--Abstract, page iv
Related
Member of
Cataloging source
UMR
http://library.link/vocab/creatorDate
1973-
http://library.link/vocab/creatorName
Park, Jongwon
Degree
Ph. D.
Dissertation year
2009.
Granting institution
Missouri University of Science and Technology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • bibliography
  • theses
http://library.link/vocab/subjectName
  • Optofluidics
  • Luminescence
  • Imaging systems in chemistry
  • Oxygen
  • Ruthenium
Label
Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration, by Jongwon Park
Instantiates
Publication
Note
  • Vita
  • The entire thesis text is included in file
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
858863652
Extent
1 online resource (xii, 77 pages)
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some colored)
System control number
(OCoLC)858863652
Label
Novel optofluidic sensor systems for quantitative chemical imaging and on-chip sensor calibration, by Jongwon Park
Publication
Note
  • Vita
  • The entire thesis text is included in file
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
858863652
Extent
1 online resource (xii, 77 pages)
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some colored)
System control number
(OCoLC)858863652

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