The Resource Probe reports from the NIH Molecular Libraries Program, (electronic resource)
Probe reports from the NIH Molecular Libraries Program, (electronic resource)
Resource Information
The item Probe reports from the NIH Molecular Libraries Program, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from all library branches.
Resource Information
The item Probe reports from the NIH Molecular Libraries Program, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from all library branches.
- Summary
- The Molecular Libraries Program (MLP), a component of the NIH Common Fund, offers public sector biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. The Molecular Libraries Probe Production Centers Network (MLPCN), as part of the MLP, is a nationwide consortium of small molecule centers that produces innovative chemical tools for use in biological research. The MLPCN solicits novel assays from the research community for high throughput screening (HTS) against a library of 350,000 chemically diverse small molecules maintained in a central repository (the Molecular Libraries Small Molecule Repository; MLSMR). Validated screening hits are optimized by medicinal chemistry to produce useful in vitro chemical probes. All of the results from the MLPCN's activities are deposited into an open access database, PubChem, for use in studying biology and disease. The MLPCN brings together over 100 experienced medicinal chemists from five academic institutions and one NIH intramural center to focus on the development of high quality probes from screening hits. The lead medicinal chemists have extensive industrial experience from both biotech and large pharmaceutical companies. MLPCN probes cover highly diverse targets, biology and disease areas with many probes moving on as potential leads in drug discovery efforts after exiting the MLPCN. This book brings together structure and biological information on the probes produced by the MLPCN in collaboration with the investigators who provided the screening assays. This information will be periodically updated with new probe information from the active MLPCN Centers
- Language
- eng
- Note
- Title from resource home page (viewed July 11, 2011)
- Contents
-
- Year 1 reports. A high-throughput screen for pre-mRNA splicing modulators
- High throughput screening for SMA
- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
- HTS for identification of inhibitors against the ERK signaling pathway using a homogenous cell-based assay
- Antagonists of IAP-family anti-apoptotic proteins
- uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells
- Three small molecule pan activator families of Ras-related GTPases
- Therapeutic Inhibitors of Phosphomannose Isomerase
- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Marion Lanier et al.
- Probe report for NOX1 inhibitors
- Therapeutic inhibitors of phosphomannose isomerase
- HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay
- The role of PHOSPHO1 in the initiation of skeletal calcification
- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Eduard Sergienko et al.
- Identification of lipid storage modulators
- Identification of activators for the M2 isoform of human pyruvate kinase
- Probe report for RBBP9 inhibitors
- Probe report for P97/cdc48 inhibitors
- Identification of functionally selective small molecule antagonists of the neuropeptide-S receptor: naphthopyranopyrimidines
- Discovery of a highly selective KCC2 antagonist
- Inhibitors of protein folding: DnaK
- Probe report for NPY-Y2 receptor antagonists
- Discovery of a highly selective in vitro and in vivo M1 allosteric agonist probe --
- Label
- Probe reports from the NIH Molecular Libraries Program
- Title
- Probe reports from the NIH Molecular Libraries Program
- Language
- eng
- Summary
- The Molecular Libraries Program (MLP), a component of the NIH Common Fund, offers public sector biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. The Molecular Libraries Probe Production Centers Network (MLPCN), as part of the MLP, is a nationwide consortium of small molecule centers that produces innovative chemical tools for use in biological research. The MLPCN solicits novel assays from the research community for high throughput screening (HTS) against a library of 350,000 chemically diverse small molecules maintained in a central repository (the Molecular Libraries Small Molecule Repository; MLSMR). Validated screening hits are optimized by medicinal chemistry to produce useful in vitro chemical probes. All of the results from the MLPCN's activities are deposited into an open access database, PubChem, for use in studying biology and disease. The MLPCN brings together over 100 experienced medicinal chemists from five academic institutions and one NIH intramural center to focus on the development of high quality probes from screening hits. The lead medicinal chemists have extensive industrial experience from both biotech and large pharmaceutical companies. MLPCN probes cover highly diverse targets, biology and disease areas with many probes moving on as potential leads in drug discovery efforts after exiting the MLPCN. This book brings together structure and biological information on the probes produced by the MLPCN in collaboration with the investigators who provided the screening assays. This information will be periodically updated with new probe information from the active MLPCN Centers
- Cataloging source
- NLM
- Government publication
- federal national government publication
- Nature of contents
- dictionaries
- NLM call number
- QY 95
- http://library.link/vocab/relatedWorkOrContributorName
-
- Molecular Libraries Program
- National Center for Biotechnology Information (U.S.)
- http://library.link/vocab/subjectName
-
- Molecular Probes
- Molecular Probe Techniques
- Label
- Probe reports from the NIH Molecular Libraries Program, (electronic resource)
- Note
- Title from resource home page (viewed July 11, 2011)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Year 1 reports. A high-throughput screen for pre-mRNA splicing modulators -- High throughput screening for SMA -- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation -- HTS for identification of inhibitors against the ERK signaling pathway using a homogenous cell-based assay -- Antagonists of IAP-family anti-apoptotic proteins -- uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells -- Three small molecule pan activator families of Ras-related GTPases -- Therapeutic Inhibitors of Phosphomannose Isomerase -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Marion Lanier et al. -- Probe report for NOX1 inhibitors -- Therapeutic inhibitors of phosphomannose isomerase -- HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay -- The role of PHOSPHO1 in the initiation of skeletal calcification -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Eduard Sergienko et al. -- Identification of lipid storage modulators -- Identification of activators for the M2 isoform of human pyruvate kinase -- Probe report for RBBP9 inhibitors -- Probe report for P97/cdc48 inhibitors -- Identification of functionally selective small molecule antagonists of the neuropeptide-S receptor: naphthopyranopyrimidines -- Discovery of a highly selective KCC2 antagonist -- Inhibitors of protein folding: DnaK -- Probe report for NPY-Y2 receptor antagonists -- Discovery of a highly selective in vitro and in vivo M1 allosteric agonist probe --
- Control code
- 717152412
- Dimensions
- unknown
- Form of item
- online
- Lccn
- 2011243305
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Publication designation
- Began in 2010?
- Specific material designation
- remote
- System control number
- (OCoLC)717152412
- System details
- Mode of access: Internet
- Label
- Probe reports from the NIH Molecular Libraries Program, (electronic resource)
- Note
- Title from resource home page (viewed July 11, 2011)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Year 1 reports. A high-throughput screen for pre-mRNA splicing modulators -- High throughput screening for SMA -- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation -- HTS for identification of inhibitors against the ERK signaling pathway using a homogenous cell-based assay -- Antagonists of IAP-family anti-apoptotic proteins -- uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells -- Three small molecule pan activator families of Ras-related GTPases -- Therapeutic Inhibitors of Phosphomannose Isomerase -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Marion Lanier et al. -- Probe report for NOX1 inhibitors -- Therapeutic inhibitors of phosphomannose isomerase -- HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay -- The role of PHOSPHO1 in the initiation of skeletal calcification -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Eduard Sergienko et al. -- Identification of lipid storage modulators -- Identification of activators for the M2 isoform of human pyruvate kinase -- Probe report for RBBP9 inhibitors -- Probe report for P97/cdc48 inhibitors -- Identification of functionally selective small molecule antagonists of the neuropeptide-S receptor: naphthopyranopyrimidines -- Discovery of a highly selective KCC2 antagonist -- Inhibitors of protein folding: DnaK -- Probe report for NPY-Y2 receptor antagonists -- Discovery of a highly selective in vitro and in vivo M1 allosteric agonist probe --
- Control code
- 717152412
- Dimensions
- unknown
- Form of item
- online
- Lccn
- 2011243305
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Publication designation
- Began in 2010?
- Specific material designation
- remote
- System control number
- (OCoLC)717152412
- System details
- Mode of access: Internet
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Probe-reports-from-the-NIH-Molecular-Libraries/s37M0mF1dwk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Probe-reports-from-the-NIH-Molecular-Libraries/s37M0mF1dwk/">Probe reports from the NIH Molecular Libraries Program, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
