The Resource Probe reports from the NIH Molecular Libraries Program, (electronic resource)

Probe reports from the NIH Molecular Libraries Program, (electronic resource)

Label
Probe reports from the NIH Molecular Libraries Program
Title
Probe reports from the NIH Molecular Libraries Program
Contributor
Subject
Language
eng
Summary
The Molecular Libraries Program (MLP), a component of the NIH Common Fund, offers public sector biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. The Molecular Libraries Probe Production Centers Network (MLPCN), as part of the MLP, is a nationwide consortium of small molecule centers that produces innovative chemical tools for use in biological research. The MLPCN solicits novel assays from the research community for high throughput screening (HTS) against a library of 350,000 chemically diverse small molecules maintained in a central repository (the Molecular Libraries Small Molecule Repository; MLSMR). Validated screening hits are optimized by medicinal chemistry to produce useful in vitro chemical probes. All of the results from the MLPCN's activities are deposited into an open access database, PubChem, for use in studying biology and disease. The MLPCN brings together over 100 experienced medicinal chemists from five academic institutions and one NIH intramural center to focus on the development of high quality probes from screening hits. The lead medicinal chemists have extensive industrial experience from both biotech and large pharmaceutical companies. MLPCN probes cover highly diverse targets, biology and disease areas with many probes moving on as potential leads in drug discovery efforts after exiting the MLPCN. This book brings together structure and biological information on the probes produced by the MLPCN in collaboration with the investigators who provided the screening assays. This information will be periodically updated with new probe information from the active MLPCN Centers
Cataloging source
NLM
Government publication
federal national government publication
Nature of contents
dictionaries
NLM call number
QY 95
http://library.link/vocab/relatedWorkOrContributorName
  • Molecular Libraries Program
  • National Center for Biotechnology Information (U.S.)
http://library.link/vocab/subjectName
  • Molecular Probes
  • Molecular Probe Techniques
Label
Probe reports from the NIH Molecular Libraries Program, (electronic resource)
Instantiates
Publication
Note
Title from resource home page (viewed July 11, 2011)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Year 1 reports. A high-throughput screen for pre-mRNA splicing modulators -- High throughput screening for SMA -- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation -- HTS for identification of inhibitors against the ERK signaling pathway using a homogenous cell-based assay -- Antagonists of IAP-family anti-apoptotic proteins -- uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells -- Three small molecule pan activator families of Ras-related GTPases -- Therapeutic Inhibitors of Phosphomannose Isomerase -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Marion Lanier et al. -- Probe report for NOX1 inhibitors -- Therapeutic inhibitors of phosphomannose isomerase -- HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay -- The role of PHOSPHO1 in the initiation of skeletal calcification -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Eduard Sergienko et al. -- Identification of lipid storage modulators -- Identification of activators for the M2 isoform of human pyruvate kinase -- Probe report for RBBP9 inhibitors -- Probe report for P97/cdc48 inhibitors -- Identification of functionally selective small molecule antagonists of the neuropeptide-S receptor: naphthopyranopyrimidines -- Discovery of a highly selective KCC2 antagonist -- Inhibitors of protein folding: DnaK -- Probe report for NPY-Y2 receptor antagonists -- Discovery of a highly selective in vitro and in vivo M1 allosteric agonist probe --
Control code
717152412
Dimensions
unknown
Form of item
online
Lccn
2011243305
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Publication designation
Began in 2010?
Specific material designation
remote
System control number
(OCoLC)717152412
System details
Mode of access: Internet
Label
Probe reports from the NIH Molecular Libraries Program, (electronic resource)
Publication
Note
Title from resource home page (viewed July 11, 2011)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Year 1 reports. A high-throughput screen for pre-mRNA splicing modulators -- High throughput screening for SMA -- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation -- HTS for identification of inhibitors against the ERK signaling pathway using a homogenous cell-based assay -- Antagonists of IAP-family anti-apoptotic proteins -- uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells -- Three small molecule pan activator families of Ras-related GTPases -- Therapeutic Inhibitors of Phosphomannose Isomerase -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Marion Lanier et al. -- Probe report for NOX1 inhibitors -- Therapeutic inhibitors of phosphomannose isomerase -- HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay -- The role of PHOSPHO1 in the initiation of skeletal calcification -- Placental Alkaline Phosphatase (PLAP) luminescent HTS assay / Eduard Sergienko et al. -- Identification of lipid storage modulators -- Identification of activators for the M2 isoform of human pyruvate kinase -- Probe report for RBBP9 inhibitors -- Probe report for P97/cdc48 inhibitors -- Identification of functionally selective small molecule antagonists of the neuropeptide-S receptor: naphthopyranopyrimidines -- Discovery of a highly selective KCC2 antagonist -- Inhibitors of protein folding: DnaK -- Probe report for NPY-Y2 receptor antagonists -- Discovery of a highly selective in vitro and in vivo M1 allosteric agonist probe --
Control code
717152412
Dimensions
unknown
Form of item
online
Lccn
2011243305
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Publication designation
Began in 2010?
Specific material designation
remote
System control number
(OCoLC)717152412
System details
Mode of access: Internet

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