Coverart for item
The Resource Protein conformational dynamics, Ke-li Han, Xin Zhang, Ming-jun Yang, editors, (electronic resource)

Protein conformational dynamics, Ke-li Han, Xin Zhang, Ming-jun Yang, editors, (electronic resource)

Label
Protein conformational dynamics
Title
Protein conformational dynamics
Statement of responsibility
Ke-li Han, Xin Zhang, Ming-jun Yang, editors
Contributor
Subject
Language
eng
Summary
  • "This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression"--Publisher's description
  • "This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression"--
Member of
Assigning source
Publisher's description
Cataloging source
CDX
Dewey number
570.3
LC call number
QP551
LC item number
.P76 2014
NLM call number
  • W1
  • QU 55.9
NLM item number
AD559 v.805 2014
http://library.link/vocab/relatedWorkOrContributorDate
1978-
http://library.link/vocab/relatedWorkOrContributorName
  • Han, Ke-Li
  • Zhang, Xin
  • Yang, Ming-jun
Series statement
Advances in experimental medicine and biology,
Series volume
volume 805
http://library.link/vocab/subjectName
  • Protein Conformation
  • Molecular Dynamics Simulation
Label
Protein conformational dynamics, Ke-li Han, Xin Zhang, Ming-jun Yang, editors, (electronic resource)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Contents
Protein folding simulations by generalized-ensemble algorithms -- Application of Markov state models to simulate long timescale dynamics of biological macromolecules -- Understanding protein dynamics using conformational ensembles -- Generative models of conformational dynamics -- Generalized spring tensor models for protein fluctuation dynamics and conformational changes -- The joys and perils of flexible fitting -- Coarse-grained models of the proteins backbone conformational dynamics -- Simulating protein folding in different environmental conditions -- Simulating the peptide folding kinetic related spectra based on the Markov state model -- The dilemma of conformational dynamics in enzyme catalysis: perspectives from theory and experiment -- Exploiting intrinsic flexibility in drug design -- NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions -- Molecular dynamics simulation of membrane proteins -- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics -- Coordination and control inside simple biomolecular machines -- Multi-state targeting machinery govern the fidelity and efficiency of protein localization -- Molecular dynamics simulations of F1-ATPase -- Chemosensorial G-proteins-coupled receptors: a perspective from computational methods
Control code
OCM1bookssj0001178944
Dimensions
unknown
Isbn
9783319029696
Isbn Type
(alk. paper)
Lccn
2014930165
Specific material designation
remote
System control number
(WaSeSS)bookssj0001178944
Label
Protein conformational dynamics, Ke-li Han, Xin Zhang, Ming-jun Yang, editors, (electronic resource)
Publication
Bibliography note
Includes bibliographical references and index
Contents
Protein folding simulations by generalized-ensemble algorithms -- Application of Markov state models to simulate long timescale dynamics of biological macromolecules -- Understanding protein dynamics using conformational ensembles -- Generative models of conformational dynamics -- Generalized spring tensor models for protein fluctuation dynamics and conformational changes -- The joys and perils of flexible fitting -- Coarse-grained models of the proteins backbone conformational dynamics -- Simulating protein folding in different environmental conditions -- Simulating the peptide folding kinetic related spectra based on the Markov state model -- The dilemma of conformational dynamics in enzyme catalysis: perspectives from theory and experiment -- Exploiting intrinsic flexibility in drug design -- NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions -- Molecular dynamics simulation of membrane proteins -- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics -- Coordination and control inside simple biomolecular machines -- Multi-state targeting machinery govern the fidelity and efficiency of protein localization -- Molecular dynamics simulations of F1-ATPase -- Chemosensorial G-proteins-coupled receptors: a perspective from computational methods
Control code
OCM1bookssj0001178944
Dimensions
unknown
Isbn
9783319029696
Isbn Type
(alk. paper)
Lccn
2014930165
Specific material designation
remote
System control number
(WaSeSS)bookssj0001178944

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