The Resource Regulation of gastrointestinal mucosal growth, Jaladanki N. Rao and Jian-Ying Wang, (electronic resource)

Regulation of gastrointestinal mucosal growth, Jaladanki N. Rao and Jian-Ying Wang, (electronic resource)

Label
Regulation of gastrointestinal mucosal growth
Title
Regulation of gastrointestinal mucosal growth
Statement of responsibility
Jaladanki N. Rao and Jian-Ying Wang
Creator
Contributor
Subject
Language
eng
Summary
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to a host of events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors (nutrients or other dietary factors, secretions, and microbes), which occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for the maintenance of the normal gut mucosal growth and could explain the villous height-crypt depth gradient and variety of adaptations since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells and polyamines are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this chapter, we highlight key issues and factors that control gastrointestinal mucosal growth, with special emphasis on the mechanisms through which epithelial renewal is regulated by polyamines at the cellular and molecular levels
Member of
Cataloging source
ORE
http://library.link/vocab/creatorName
Rao, Jaladanki N
Dewey number
616.33
Illustrations
illustrations
Index
no index present
LC call number
QP156
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WI 402
http://library.link/vocab/relatedWorkOrContributorName
Wang, J.-Y.
Series statement
Colloquium series in integrated systems physiology,
Series volume
15
http://library.link/vocab/subjectName
  • Gastrointestinal mucosa
  • Gastric Mucosa
  • Intestinal Mucosa
  • Gastrointestinal Tract
  • Polyamines
Label
Regulation of gastrointestinal mucosal growth, Jaladanki N. Rao and Jian-Ying Wang, (electronic resource)
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Intestinal architecture and development -- Intestinal stem cells -- Role of GI hormones on gut mucosal growth -- Peptide growth factors in GI mucosal growth -- Luminal nutrients and microbes in gut mucosal growth -- Polyamines in the regulation of mucosal growth
Control code
712603437
Extent
1 online resource (viii, 104 pages)
Form of item
online
Isbn
9781615041336
Isbn Type
(electronic bk.)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00028ED1V01Y201103ISP015
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)712603437
Label
Regulation of gastrointestinal mucosal growth, Jaladanki N. Rao and Jian-Ying Wang, (electronic resource)
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Intestinal architecture and development -- Intestinal stem cells -- Role of GI hormones on gut mucosal growth -- Peptide growth factors in GI mucosal growth -- Luminal nutrients and microbes in gut mucosal growth -- Polyamines in the regulation of mucosal growth
Control code
712603437
Extent
1 online resource (viii, 104 pages)
Form of item
online
Isbn
9781615041336
Isbn Type
(electronic bk.)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00028ED1V01Y201103ISP015
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)712603437

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