Borrow it
Coverart for item
The Resource Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors, Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies

Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors, Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies

Creator
Author
Summary
"Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation"--Publisher's description
Language
eng
Work
Publication
Extent
1 online resource (xii, 51 pages)
Contents
  • Introduction
  • Review of the Environmental Protection Agency's methods for evaluating evidence on nonmonotonic dose-response relationships
  • The Environmental Protection Agency's evaluation of implications of nonmonotonic dose-response relationships for current toxicity-testing strategies and risk-assessment practices
Isbn
9780309297554
Instance
Label
Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors
Title
Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors
Statement of responsibility
Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies
Title variation
  • State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors
  • Review of the EPA's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors
Creator
Author
Subject
Genre
Language
eng
Summary
"Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation"--Publisher's description
Member of
Cataloging source
MMU
Dewey number
616.4/06
Illustrations
illustrations
Index
no index present
Language note
English
LC call number
RA1224.2
LC item number
.N38 2014
Literary form
non fiction
NAL call number
RA1224.2
NAL item number
.N38 2014
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WK 102
http://bibfra.me/vocab/lite/organizationName
National Research Council (U.S.)
http://library.link/vocab/subjectName
  • Endocrine disrupting chemicals
  • Endocrine disrupting chemicals
  • Dose-response relationship (Biochemistry)
  • Endocrine toxicology
  • Endocrine Disruptors
  • Dose-Response Relationship, Drug
  • Evaluation Studies as Topic
  • Toxicity Tests
  • Risk Assessment
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Dose-response relationship (Biochemistry)
  • Endocrine disrupting chemicals
  • Endocrine toxicology
Label
Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors, Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Review of the Environmental Protection Agency's methods for evaluating evidence on nonmonotonic dose-response relationships -- The Environmental Protection Agency's evaluation of implications of nonmonotonic dose-response relationships for current toxicity-testing strategies and risk-assessment practices
Control code
880724829
Extent
1 online resource (xii, 51 pages)
Form of item
online
Isbn
9780309297554
Lccn
2014497361
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)880724829
Label
Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors, Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies
Publication
Copyright
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Review of the Environmental Protection Agency's methods for evaluating evidence on nonmonotonic dose-response relationships -- The Environmental Protection Agency's evaluation of implications of nonmonotonic dose-response relationships for current toxicity-testing strategies and risk-assessment practices
Control code
880724829
Extent
1 online resource (xii, 51 pages)
Form of item
online
Isbn
9780309297554
Lccn
2014497361
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)880724829

Subject

Genre

Member of

Library Locations

  • St. Louis Mercantile LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • Thomas Jefferson LibraryBorrow it
    1 University Blvd, St. Louis, MO, 63121, US
    38.710138 -90.311107
  • University ArchivesBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • University of Missouri-St. Louis Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
  • Ward E Barnes Education LibraryBorrow it
    8001 Natural Bridge Rd, St. Louis, MO, 63121, US
    38.707079 -90.311355

Library Links

Structured data from the Bibframe namespace is licensed under the Creative Commons Attribution 4.0 International License by University of Missouri-St. Louis Libraries. Additional terms may apply to data associated with third party namespaces.
Processing Feedback ...