The Resource Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
Resource Information
The item Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from all library branches.
Resource Information
The item Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from all library branches.
- Summary
- Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method
- Language
- eng
- Publication
-
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center;, Springfield, VA, Available through the National Technical Information Service, 2005
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center, Springfield, VA, Available through the National Technical Information Service, 2005
- Extent
- i, 18 pages
- Note
-
- Title from PDF t.p. (viewed May 24, 2006)
- "May 2005."
- "DOT/FAA/AM-05/10."
- Label
- Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report
- Title
- Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS
- Title remainder
- final report
- Statement of responsibility
- Robert D. Johnson, Russell J. Lewis
- Subject
-
- Adrenergic beta blockers -- Analysis
- Adrenergic beta-Antagonists -- analysis
- Aerospace Medicine -- methods
- Aircraft accidents
- Chromatography, Liquid -- methods
- Electronic government information -- United States
- Government publications -- United States
- Hypertension -- Treatment
- Hypertension -- drug therapy
- Mass Spectrometry -- methods
- Propanolamines -- Analysis
- Technical Report
- United States
- Accidents, Aviation
- Language
- eng
- Summary
- Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method
- Additional physical form
- Also available in print.
- Cataloging source
- NLM
- http://library.link/vocab/creatorDate
- 1974-
- http://library.link/vocab/creatorName
- Johnson, Robert D.
- Funding information
- Performed by FAA Civil Aerospace Medical Institute under approved task no.
- Government publication
- federal national government publication
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- technical reports
- NLM call number
- QV 132
- http://library.link/vocab/relatedWorkOrContributorName
-
- Lewis, Russell J
- United States
- Civil Aerospace Medical Institute
- http://library.link/vocab/subjectName
-
- Adrenergic beta blockers
- Aircraft accidents
- Hypertension
- Propanolamines
- Adrenergic beta-Antagonists
- Accidents, Aviation
- Aerospace Medicine
- Chromatography, Liquid
- Hypertension
- Mass Spectrometry
- United States
- Label
- Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
- Publication
-
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center;, Springfield, VA, Available through the National Technical Information Service, 2005
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center, Springfield, VA, Available through the National Technical Information Service, 2005
- Note
-
- Title from PDF t.p. (viewed May 24, 2006)
- "May 2005."
- "DOT/FAA/AM-05/10."
- Bibliography note
- Includes bibliographical references (pages 6-7)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 70829610
- Dimensions
- unknown
- Extent
- i, 18 pages
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- digital, PDF file
- Specific material designation
- remote
- System details
- Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0510.pdf; current access via PURL
- Label
- Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
- Publication
-
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center;, Springfield, VA, Available through the National Technical Information Service, 2005
- Washington, DC, U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvoir, VA, Available through the Defense Technical Information Center, Springfield, VA, Available through the National Technical Information Service, 2005
- Note
-
- Title from PDF t.p. (viewed May 24, 2006)
- "May 2005."
- "DOT/FAA/AM-05/10."
- Bibliography note
- Includes bibliographical references (pages 6-7)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 70829610
- Dimensions
- unknown
- Extent
- i, 18 pages
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- digital, PDF file
- Specific material designation
- remote
- System details
- Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0510.pdf; current access via PURL
Subject
- Adrenergic beta blockers -- Analysis
- Adrenergic beta-Antagonists -- analysis
- Aerospace Medicine -- methods
- Aircraft accidents
- Chromatography, Liquid -- methods
- Electronic government information -- United States
- Government publications -- United States
- Hypertension -- Treatment
- Hypertension -- drug therapy
- Mass Spectrometry -- methods
- Propanolamines -- Analysis
- Technical Report
- United States
- Accidents, Aviation
Genre
Library Locations
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St. Louis Mercantile LibraryBorrow it1 University Blvd, St. Louis, MO, 63121, US38.710138 -90.311107
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University of Missouri-St. Louis Libraries DepositoryBorrow it2908 Lemone Blvd, Columbia, MO, 65201, US38.919360 -92.291620
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University of Missouri-St. Louis Libraries DepositoryBorrow it2908 Lemone Blvd, Columbia, MO, 65201, US38.919360 -92.291620
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Ward E Barnes Education LibraryBorrow it8001 Natural Bridge Rd, St. Louis, MO, 63121, US38.707079 -90.311355
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/Simultaneous-quantitation-of-atenolol/EbGeNmK2kDs/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/Simultaneous-quantitation-of-atenolol/EbGeNmK2kDs/">Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
