The Resource Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns, by Eddie LaReece Pittman

Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns, by Eddie LaReece Pittman

Label
Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
Title
Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
Statement of responsibility
by Eddie LaReece Pittman
Title variation
Spectroscopic distinguishability, forced degradation kinetics and liquid chromatography-tandem mass spectrometry degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
5-Fluorouracil (5-FU) is a commonly used antiviral and anticancer drug. 5- FU is believed to exist in various tautomeric forms, which are believed to contribute to 5-FUs cytotoxicity. In order to understand the activity of 5-FU in biological and environmental settings, a combined theoretical and experimental approach was used to determine the predominant tautomer in aqueous environments. Spectral characterization of 5-FU will enable development of improved analytical methods for 5-FU. The structures of the 6 most relevant tautomers of 5-FU were optimized using DFT (B3LYP/6-311++G(d, p)) and their respective UV absorption, IR, Raman and NMR spectra calculated. The UV resonance Raman spectrum of 5-FU is also reported. The C=O (1711(cm-1 )), C=C (1673(cm-1 )) and C-N (1463(cm-1 )) and N-H (1510(cm-1 )) stretching frequencies are strongly enhanced in the deep UV resonance Raman spectrum of 5-FU. Comparison of the theoretical spectra with measured UV absorption, IR, UV Raman and NMR indicate that the 5-FU keto tautomer is the predominant species in aqueous environments. Four applicable set of environmental conditions were applied towards 5- FU which all produced results that can be used to help further the overall agenda. Thermal/Saline and Photolytic/Alkali both completely degraded 5-FU but Thermal/Saline did it quicker. While the Thermal/Alkali caused some degradation over the course of a week, Thermal/Acidic didnt come close to matching over the same period of time. Synergism was demonstrated and definitely raises even more concerns regarding the realistic adverse potential these sort of compounds may have once they make their way into the environment; thus, this studys statement was made
Cataloging source
MUU
http://library.link/vocab/creatorName
Pittman, Eddie LaReece
Degree
PhD
Dissertation note
Thesis
Dissertation year
2015.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1965-
http://library.link/vocab/relatedWorkOrContributorName
  • JiJi, Renée Denise
  • Lin, Chung-Ho
http://library.link/vocab/subjectName
  • Fluorouracil
  • Spectrum analysis
  • Liquid chromatography
  • Tandem mass spectrometry
  • Drug stability
  • Environmental protection
Label
Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns, by Eddie LaReece Pittman
Instantiates
Publication
Note
  • "A Dissertation Presented to The faculty of the Graduate School University of Missouri-Columbia In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisors: Drs. Renee JiJi & Chung-Ho Lin
  • Includes vita
Bibliography note
Includes bibliographical references (pages 104-106)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
961478061
Extent
1 online resource (x, 673 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)961478061
Label
Spectroscopic distinguishability, forced degradation kinetics and LC-MS/MS degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns, by Eddie LaReece Pittman
Publication
Note
  • "A Dissertation Presented to The faculty of the Graduate School University of Missouri-Columbia In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisors: Drs. Renee JiJi & Chung-Ho Lin
  • Includes vita
Bibliography note
Includes bibliographical references (pages 104-106)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
961478061
Extent
1 online resource (x, 673 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)961478061

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