Coverart for item
The Resource Structure-based drug discovery : an overview, edited by Roderick E. Hubbard

Structure-based drug discovery : an overview, edited by Roderick E. Hubbard

Label
Structure-based drug discovery : an overview
Title
Structure-based drug discovery
Title remainder
an overview
Statement of responsibility
edited by Roderick E. Hubbard
Contributor
Subject
Genre
Language
eng
Summary
Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences
Member of
Cataloging source
UKRSC
Dewey number
615.19
Illustrations
illustrations
Index
index present
LC call number
RS420
LC item number
.S768 2006eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Hubbard, R. E
Series statement
RSC biomolecular sciences
http://library.link/vocab/subjectName
  • Drugs
  • Drugs
  • Drug Design
  • Models, Theoretical
  • Pharmacological Phenomena
  • Drug Discovery
  • Biochemical Phenomena
  • Chemistry, Pharmaceutical
  • Investigative Techniques
  • Chemical Phenomena
  • Physiological Phenomena
  • Chemistry
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Phenomena and Processes
  • Pharmacology
  • Biological Science Disciplines
  • Natural Science Disciplines
  • Disciplines and Occupations
  • Models, Molecular
  • Structure-Activity Relationship
  • Chemistry
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Science
  • Drugs
  • Drugs
  • Arzneimitteldesign
  • Arzneimittelentwicklung
  • Biomolekül
  • Konfiguration
  • Struktur-Aktivitäts-Beziehung
Label
Structure-based drug discovery : an overview, edited by Roderick E. Hubbard
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
3D structure and the drug discovery process / Roderick E. Hubbard -- Structure determination : crystallography for structure-based drug discovery / David G. Brown and Maria M. Flocco -- Molecular modelling / Xavier Barril and Robert Soliva -- Applications of NMR in structure-based drug discovery / Ben Davis and Julia Hubbard-- Fragment screening : an introduction / Andrew R. Leach, Michael M. Hann, Jeremy N. Burrows and Ed Griffen -- Iterative structure-based screening of virtual chemical libraries and Factor Xa : finding the orally available antithrombotic candidate LY517717 / John W. Liebeschuetz, Stuart D. Jones, Michael R. Wiley and Steven C. Young -- Anti-influenza drugs from neuraminidase inhibitors -- Isoform specificity : the design of estrogen receptor-[beta] selective compounds / Peter Colman
Control code
232638063
Dimensions
unknown
Extent
1 online resource (xvi, 261 pages)
Form of item
online
Isbn
9780854043514
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
10.1039/9781847552549
Specific material designation
remote
System control number
(OCoLC)232638063
Label
Structure-based drug discovery : an overview, edited by Roderick E. Hubbard
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
3D structure and the drug discovery process / Roderick E. Hubbard -- Structure determination : crystallography for structure-based drug discovery / David G. Brown and Maria M. Flocco -- Molecular modelling / Xavier Barril and Robert Soliva -- Applications of NMR in structure-based drug discovery / Ben Davis and Julia Hubbard-- Fragment screening : an introduction / Andrew R. Leach, Michael M. Hann, Jeremy N. Burrows and Ed Griffen -- Iterative structure-based screening of virtual chemical libraries and Factor Xa : finding the orally available antithrombotic candidate LY517717 / John W. Liebeschuetz, Stuart D. Jones, Michael R. Wiley and Steven C. Young -- Anti-influenza drugs from neuraminidase inhibitors -- Isoform specificity : the design of estrogen receptor-[beta] selective compounds / Peter Colman
Control code
232638063
Dimensions
unknown
Extent
1 online resource (xvi, 261 pages)
Form of item
online
Isbn
9780854043514
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
10.1039/9781847552549
Specific material designation
remote
System control number
(OCoLC)232638063

Library Locations

    • Thomas Jefferson LibraryBorrow it
      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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