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The Resource Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging, By Amal Yousif Al-Yasiri

Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging, By Amal Yousif Al-Yasiri

Creator
Author
Contributor
Summary
The main goal of this dissertation was to explore new protocols to synthesize biocompatible radioactive gold nanoparticles to treat and image cancer and calculate the dose distribution by using MCNP in tumor inside the human prostate as well as surrounding normal tissues. This dissertation is classified into three parts or projects. The objective of the first project is production and evaluation of radioactive MGF- 198AuNPs and MGF- 199AuNPs towards prostate cancer treatment and imaging. Non-radioactive MGF-AuNPs were synthesized first and in vitro evaluated. Results of In vitro evaluation showed that this type of nanoparticles is stable, non toxic, and can be internalized into prostate cancer cells. Next, new modified protocols were developed to produce radioactive MGF- 198AuNPs and MGF- 199AuNPs. UV-Vis spectroscopy and TLC measurements showed that these radioactive MGF- 198AuNPs and MGF- 199AuNPs are stable and more than 96% of radioactive gold was within nanoparticlate structure. Then, MGF- 198AuNPs were in vivo evaluated to investigate their in vivo stability, retention in tumor, and efficacy to cure prostate cancer. The results indicated that MGF- 198AuNPs are stable and have excellent ability to be retained within the tumor up to 24 hours with very minimum leakage to non-target organs. It was also found that radioactive MGF- 198AuNPs have significant therapeutic effect and that they were able to control the tumor size in comparison to control group. The objective of the second project is production and evaluation of radioactive citrate- 199AuNPs as imaging probe for single photon emission computed tomography. In this study, a new protocol was developed to synthesize radioactive citrate- 199AuNPs, UV-Vis spectroscopy and TLC measurements showed that new protocol was successful to produce stable radioactive citrate- 199AuNPs. Also, In vivo evaluation results showed that citrate- 199AuNPs are stable in vivo and therefore, they can be used in imaging procedures. The objective of the third project is estimation, by means of MCNP simulations, the dose distribution delivered by radioactive gold nanoparticles (198AuNPs or199AuNPs) to tumor inside the human prostate as well as to the normal tissues surrounding the tumor, using water and A-150 tissue equivalent plastic phantoms. A simple geometrical model of a human prostate was used, and the dose distribution that is deposited by radioactive gold nanoparticles (198AuNPs or 199AuNPs) was calculated using MCNP. The results showed that the deposited dose by 198AuNPs or 199AuNPs, which are distributed homogenously in the tumor, has maximum value at the tumor region and then decreases toward the normal tissue in the prostate as well as surrounding organs. However, the dose deposited by 198Au is significantly higher than the dose deposited by 199Au at the tumor region as well as normal tissues. Therefore 198Au should be preferred to for therapeutic applications, while should be preferred for 199Au in imaging applications
Language
eng
Work
Publication
Extent
1 online resource (xv, 124 pages)
Note
  • "A Dissertation Presented to the Faculty of the Graduate School at the University of Missouri Columbia In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisors: Dr. Kattesh V. Katti and Dr. Sudarshan K. Loyalka
  • Includes vita
Instance
Label
Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
Title
Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
Statement of responsibility
By Amal Yousif Al-Yasiri
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
The main goal of this dissertation was to explore new protocols to synthesize biocompatible radioactive gold nanoparticles to treat and image cancer and calculate the dose distribution by using MCNP in tumor inside the human prostate as well as surrounding normal tissues. This dissertation is classified into three parts or projects. The objective of the first project is production and evaluation of radioactive MGF- 198AuNPs and MGF- 199AuNPs towards prostate cancer treatment and imaging. Non-radioactive MGF-AuNPs were synthesized first and in vitro evaluated. Results of In vitro evaluation showed that this type of nanoparticles is stable, non toxic, and can be internalized into prostate cancer cells. Next, new modified protocols were developed to produce radioactive MGF- 198AuNPs and MGF- 199AuNPs. UV-Vis spectroscopy and TLC measurements showed that these radioactive MGF- 198AuNPs and MGF- 199AuNPs are stable and more than 96% of radioactive gold was within nanoparticlate structure. Then, MGF- 198AuNPs were in vivo evaluated to investigate their in vivo stability, retention in tumor, and efficacy to cure prostate cancer. The results indicated that MGF- 198AuNPs are stable and have excellent ability to be retained within the tumor up to 24 hours with very minimum leakage to non-target organs. It was also found that radioactive MGF- 198AuNPs have significant therapeutic effect and that they were able to control the tumor size in comparison to control group. The objective of the second project is production and evaluation of radioactive citrate- 199AuNPs as imaging probe for single photon emission computed tomography. In this study, a new protocol was developed to synthesize radioactive citrate- 199AuNPs, UV-Vis spectroscopy and TLC measurements showed that new protocol was successful to produce stable radioactive citrate- 199AuNPs. Also, In vivo evaluation results showed that citrate- 199AuNPs are stable in vivo and therefore, they can be used in imaging procedures. The objective of the third project is estimation, by means of MCNP simulations, the dose distribution delivered by radioactive gold nanoparticles (198AuNPs or199AuNPs) to tumor inside the human prostate as well as to the normal tissues surrounding the tumor, using water and A-150 tissue equivalent plastic phantoms. A simple geometrical model of a human prostate was used, and the dose distribution that is deposited by radioactive gold nanoparticles (198AuNPs or 199AuNPs) was calculated using MCNP. The results showed that the deposited dose by 198AuNPs or 199AuNPs, which are distributed homogenously in the tumor, has maximum value at the tumor region and then decreases toward the normal tissue in the prostate as well as surrounding organs. However, the dose deposited by 198Au is significantly higher than the dose deposited by 199Au at the tumor region as well as normal tissues. Therefore 198Au should be preferred to for therapeutic applications, while should be preferred for 199Au in imaging applications
Cataloging source
MUU
http://library.link/vocab/creatorName
Al-Yasiri, Amal Yousif
Degree
PhD
Dissertation note
Thesis
Dissertation year
2015.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
  • Katti, Kattesh V.
  • Loyalka, S. K.
http://library.link/vocab/subjectName
  • Cancer
  • Cancer
  • Nanomedicine
  • Nanoparticles
  • Monte Carlo method
Label
Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging, By Amal Yousif Al-Yasiri
Instantiates
Publication
Copyright
Note
  • "A Dissertation Presented to the Faculty of the Graduate School at the University of Missouri Columbia In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisors: Dr. Kattesh V. Katti and Dr. Sudarshan K. Loyalka
  • Includes vita
Bibliography note
Includes bibliographical references (pages 118-123)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
958839628
Extent
1 online resource (xv, 124 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)958839628
Label
Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging, By Amal Yousif Al-Yasiri
Publication
Copyright
Note
  • "A Dissertation Presented to the Faculty of the Graduate School at the University of Missouri Columbia In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisors: Dr. Kattesh V. Katti and Dr. Sudarshan K. Loyalka
  • Includes vita
Bibliography note
Includes bibliographical references (pages 118-123)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
958839628
Extent
1 online resource (xv, 124 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)958839628

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