The Resource Synthesis and structure-activity relationship of a series of sigma receptor ligands, by Roger I. Nahas, (electronic resource)

Synthesis and structure-activity relationship of a series of sigma receptor ligands, by Roger I. Nahas, (electronic resource)

Label
Synthesis and structure-activity relationship of a series of sigma receptor ligands
Title
Synthesis and structure-activity relationship of a series of sigma receptor ligands
Statement of responsibility
by Roger I. Nahas
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual structure-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution pattern representing three physico-chemical parameters denoting size, hydrophobicity, and electronic characteristics, in order to study the effect of those properties on the biological activity. Structure-activity relationships (SAR) were evaluated qualitatively to describe the effect of the systematic benzyl substitution in comparison to the phenylpropyl substitution. High quality mathematical equations were derived to quantitatively express the statistical correlation between the biological activity and the physico-chemical parameters associated with the benzyl ring substitution. Finally, the effect of the piperidine moiety was compared to the piperazine in a systematic and coherent fashion. This SAR study will result in a better comprehension of the interaction between the sigma protein receptors and the ligands, a better understanding of the pharmacophore profile, and a more effective design for future potent sigma receptor ligands
Cataloging source
MUU
http://library.link/vocab/creatorDate
1978-
http://library.link/vocab/creatorName
Nahas, Roger I.
Degree
Ph. D.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Lever, Susan Z., 1952-
http://library.link/vocab/subjectName
  • Sigma receptors
  • Receptor-ligand complexes
  • Ligand binding (Biochemistry)
Target audience
specialized
Label
Synthesis and structure-activity relationship of a series of sigma receptor ligands, by Roger I. Nahas, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on February 26, 2008)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
210121147
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)210121147
System details
Mode of access: World Wide Web
Label
Synthesis and structure-activity relationship of a series of sigma receptor ligands, by Roger I. Nahas, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on February 26, 2008)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
210121147
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)210121147
System details
Mode of access: World Wide Web

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