The Resource Synthesis of rhenium complexes as models for new sigma receptor imaging agents, by Peter Chen, (electronic resource)

Synthesis of rhenium complexes as models for new sigma receptor imaging agents, by Peter Chen, (electronic resource)

Label
Synthesis of rhenium complexes as models for new sigma receptor imaging agents
Title
Synthesis of rhenium complexes as models for new sigma receptor imaging agents
Statement of responsibility
by Peter Chen
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The sigma receptor has been biologically found to play roles in the central nervous system (CNS) disorders and cancer cell proliferation. With the identification of lead sigma receptor binding ligands by previous structure activity relationship (SAR) studies, new sigma Tc-99[superscript m] sigma receptor imaging agents were designed. Tc-99 [superscript m] imaging agents provide the advantages for routing clinical use due to its ideal nuclear properties (t1/2=6 hours and 140 keV gamma photon emission) and being readily available from a 99Mo/99[superscript m] Tc generator. The stability, structure, and biodistribution of rhenium complexes have been found similar to their Tc-99 [superscript m] counterparts. Non-radioactive rhenium surrogates serve as a useful precursor for the radioactive Tc-99 [superscript m] imaging agents. The Re/Tc-99 [superscript m] are bound by the amide-amine-dithiol tetradentate (AADT) chelate and linked onto the sigma moieties following the bifunctional chelate approach. The current study, successfully synthesized the chelate, sigma moieties, and target rhenium surrogates toward the goal of developing new sigma receptor imaging agents
Cataloging source
MUU
http://library.link/vocab/creatorDate
1984-
http://library.link/vocab/creatorName
Chen, Peter
Degree
M.S.
Dissertation year
2009.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
Lever, Susan Z.
http://library.link/vocab/subjectName
  • Sigma receptors
  • Rhenium compounds
  • Imaging systems in chemistry
  • Cancer cells
  • Central nervous system
Target audience
specialized
Label
Synthesis of rhenium complexes as models for new sigma receptor imaging agents, by Peter Chen, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on February 22, 2011)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Thesis advisor: Dr. Susan Z. Lever
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
703666966
Extent
1 online resource (ix, 109 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)703666966
Label
Synthesis of rhenium complexes as models for new sigma receptor imaging agents, by Peter Chen, (electronic resource)
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on February 22, 2011)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Thesis advisor: Dr. Susan Z. Lever
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
703666966
Extent
1 online resource (ix, 109 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)703666966

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