The Resource The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
Resource Information
The item The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.This item is available to borrow from all library branches.
Resource Information
The item The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries.
This item is available to borrow from all library branches.
- Summary
- During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens
- Language
- eng
- Extent
- i, 10 pages
- Note
-
- Tile from title screen (viewed on Sept. 27, 2006)
- "July 2006"
- "DOT/FAA/AM-06/17."
- Label
- The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report
- Title
- The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens
- Title remainder
- final report
- Statement of responsibility
- Robert D. Johnson, Russell J. Lewis, Mike K. Angier
- Title variation
- Liquid chromatography/mass spectrometry quantification of vardenafil (Levitra®) in postmortem biological specimens
- Language
- eng
- Summary
- During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens
- Cataloging source
- GPO
- http://library.link/vocab/creatorDate
- 1974-
- http://library.link/vocab/creatorName
- Johnson, Robert D.
- Funding information
- Performed by FAA Civil Aerospace Medical Institute, Oklahoma City, OK, under approved task no.
- Government publication
- federal national government publication
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- technical reports
- http://library.link/vocab/relatedWorkOrContributorName
-
- Lewis, Russell J
- Angier, Mike K
- United States
- United States
- Civil Aerospace Medical Institute
- http://library.link/vocab/subjectName
-
- Forensic toxicology
- Impotence
- Aircraft accidents
- Label
- The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
- Note
-
- Tile from title screen (viewed on Sept. 27, 2006)
- "July 2006"
- "DOT/FAA/AM-06/17."
- Bibliography note
- Includes bibliographical references (page 10)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- black and white
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 71782070
- Dimensions
- unknown
- Extent
- i, 10 pages
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- digital, PDF file
- Specific material designation
- remote
- System details
- Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/200617.pdf; current access via PURL
- Label
- The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
- Note
-
- Tile from title screen (viewed on Sept. 27, 2006)
- "July 2006"
- "DOT/FAA/AM-06/17."
- Bibliography note
- Includes bibliographical references (page 10)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- black and white
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 71782070
- Dimensions
- unknown
- Extent
- i, 10 pages
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- digital, PDF file
- Specific material designation
- remote
- System details
- Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/200617.pdf; current access via PURL
Library Locations
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St. Louis Mercantile LibraryBorrow it1 University Blvd, St. Louis, MO, 63121, US38.710138 -90.311107
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University ArchivesBorrow it703 Lewis Hall, Columbia, MO, 65211, US
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University of Missouri-St. Louis Libraries DepositoryBorrow it2908 Lemone Blvd, Columbia, MO, 65201, US38.919360 -92.291620
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University of Missouri-St. Louis Libraries DepositoryBorrow it2908 Lemone Blvd, Columbia, MO, 65201, US38.919360 -92.291620
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Ward E Barnes Education LibraryBorrow it8001 Natural Bridge Rd, St. Louis, MO, 63121, US38.707079 -90.311355
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/portal/The-LCMS-quantification-of-vardenafil-Levitra%C2%AE/iiUFv3LV6gs/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/portal/The-LCMS-quantification-of-vardenafil-Levitra%C2%AE/iiUFv3LV6gs/">The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
