The Resource The control of blood flow in skeletal muscle arterioles, by Curt Canine

The control of blood flow in skeletal muscle arterioles, by Curt Canine

Label
The control of blood flow in skeletal muscle arterioles
Title
The control of blood flow in skeletal muscle arterioles
Statement of responsibility
by Curt Canine
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Skeletal muscle arterioles dilate in response to application of acetylcholine (ACh), eliciting a conducted vasodilation (CVD) that travels along unbranched segments without decrement. CVD is known to entail cell-to-cell transmission of hyperpolarization along the endothelium via gap junction channels, a purely passive mechanism. In the present thesis I study CVD in bifurcating arteriolar networks, where the pathway for hyperpolarizing current expands compared to unbranched arterioles, to test for an active component to CVD. In a separate subset of arterioles, the effect of augmenting vasomotor tone on CVD was tested using elevated O2 or phenylephrine (PE) in the superfusion solution vs. control. Male C57BL/6 mice (n=13; 10-13 weeks old) were anesthetized with pentobarbital sodium (50mg/kg, intraperitoneal injection) and maintained at 37 °C. The cremaster was carefully exteriorized and spread onto a transparent Sylgard pedestal. The tissue was maintained at 34 °C with continuous superfusion of physiologic saline solution. Microiontophoresis of ACh evoked non-decremental CVD in both unbranched and bifurcating arterioles, supporting the role of an active component in CVD. Further, augmenting vasomotor tone with PE attenuated non-decremental CVD, whereas increasing vasomotor tone with elevated O2 did not alter CVD. In summary, arteriolar networks in the mouse cremaster muscle exhibit robust dilation to ACh, which conducts along arterioles and across branch points without decrement, suggesting the contribution of both active and passive mechanisms. In preparations exhibiting poor spontaneous vasomotor tone, elevated O2 can be used to improve resting tone without impacting CVD
Cataloging source
MUU
http://library.link/vocab/creatorName
Canine, Curt
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2010.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Segal, Steven S.
Label
The control of blood flow in skeletal muscle arterioles, by Curt Canine
Instantiates
Publication
Note
  • "December 2010."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Steven Segal
Bibliography note
Includes bibliographical references (pages 51-58)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
900559520
Extent
1 online resource (ix, 58 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)900559520
Label
The control of blood flow in skeletal muscle arterioles, by Curt Canine
Publication
Note
  • "December 2010."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Steven Segal
Bibliography note
Includes bibliographical references (pages 51-58)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
900559520
Extent
1 online resource (ix, 58 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)900559520

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