The Resource The endothelium, Michel Félétou, (electronic resource)

The endothelium, Michel Félétou, (electronic resource)

Label
The endothelium
Title
The endothelium
Statement of responsibility
Michel Félétou
Creator
Subject
Language
eng
Summary
  • Part I: Multiple functions of the endothelial cells--focus on endothelium-derived vasoactive mediators. The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation
  • Part 2: EDHF-mediated responses "The classical pathway." The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca2+ concentration of the endothelial cells followed by the opening of Ca2+-activated K+ channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na+/K+-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHF-mediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases
Member of
Cataloging source
CUS
http://library.link/vocab/creatorDate
1956-
http://library.link/vocab/creatorName
Félétou, Michel
Dewey number
612.13
Illustrations
illustrations
Index
no index present
LC call number
QP88.45
LC item number
.F454 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QS 532.5.E7
Series statement
Integrated systems physiology : from molecule to function to disease
Series volume
#19-20
http://library.link/vocab/subjectName
  • Vascular endothelium
  • Blood flow
  • Endothelium
  • Endothelium, Vascular
  • Biological Factors
  • Endothelial Cells
  • Endothelins
  • Endothelium-Dependent Relaxing Factors
Label
The endothelium, Michel Félétou, (electronic resource)
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
pt. 1. Multiple functions of the endothelial cells, focus on endothelium-derived vasoactive mediators -- pt. 2. EDHF-mediated responses "The classical pathway"
Control code
744652804
Extent
1 online resource (2 volumes)
Form of item
online
Isbn
9781615041244
Isbn Type
(pt. 1)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)744652804
Label
The endothelium, Michel Félétou, (electronic resource)
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
pt. 1. Multiple functions of the endothelial cells, focus on endothelium-derived vasoactive mediators -- pt. 2. EDHF-mediated responses "The classical pathway"
Control code
744652804
Extent
1 online resource (2 volumes)
Form of item
online
Isbn
9781615041244
Isbn Type
(pt. 1)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)744652804

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