The Resource The maculoprotective effect of a thiol antioxidant in retinal degeneration models, by Hsiu-Jen Wang

The maculoprotective effect of a thiol antioxidant in retinal degeneration models, by Hsiu-Jen Wang

Label
The maculoprotective effect of a thiol antioxidant in retinal degeneration models
Title
The maculoprotective effect of a thiol antioxidant in retinal degeneration models
Statement of responsibility
by Hsiu-Jen Wang
Creator
Contributor
Author
Subject
Language
eng
Summary
"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. Currently, there is no FDA-approved treatment for AMD. Therefore, we hypothesized that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we used the oxidants tert-butyl hydroperoxide (TBHP) and sodium iodate (NaIO3) in a cell model and an animal model to evaluate the effects of NACA. Our data suggest that pretreatment with NACA reduces the sub-lethal (but not lethal) effects of TBHP in primary cultures of human retinal pigment epithelial cells. NACA significantly improves cell survival when administered prior to and during the occurrence of oxidative damage similar to that observed in the development of dry AMD. In the chemically- induced retinal degeneration animal model, NACA eye drops partially prevented reduction in visual function, as determined from electroretinograms (ERG) recorded 36 hours after NaIO3 injection. Other toxic effects were observed at a later time point after NaIO3 injection: increased lipid peroxidation (as measured by formation of 4-hydroxynonenal, 4-HNE), elevated cysteine levels, and death of photoreceptors resulting in outer nuclear layer thinning. NACA eye drops reversed these toxic effects. In conclusion, this potent antioxidant should continue to be investigated as a treatment for AMD"--Abstract, page iv
Related
Member of
Cataloging source
UMR
http://library.link/vocab/creatorDate
1971-
http://library.link/vocab/creatorName
Wang, Hsiu-Jen
Degree
Ph. D.
Dissertation year
2017
Funding information
Financial support of National Institutes of Health (U.S.)
Granting institution
Missouri University of Science and Technology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
  • National Eye Institute
  • National Institutes of Health (U.S.)
Label
The maculoprotective effect of a thiol antioxidant in retinal degeneration models, by Hsiu-Jen Wang
Instantiates
Publication
Note
  • Vita
  • This dissertation contains two papers for publication
Bibliography note
Includes bibliographic references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
1021857689
Extent
1 online resource (xx, 122 pages)
Form of item
online
Governing access note
These materials are protected under copyright by the original author
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)1021857689
Label
The maculoprotective effect of a thiol antioxidant in retinal degeneration models, by Hsiu-Jen Wang
Publication
Note
  • Vita
  • This dissertation contains two papers for publication
Bibliography note
Includes bibliographic references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
1021857689
Extent
1 online resource (xx, 122 pages)
Form of item
online
Governing access note
These materials are protected under copyright by the original author
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)1021857689

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