Coverart for item
The Resource The prevention and treatment of missing data in clinical trials, Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies

The prevention and treatment of missing data in clinical trials, Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies

Label
The prevention and treatment of missing data in clinical trials
Title
The prevention and treatment of missing data in clinical trials
Statement of responsibility
Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies
Creator
Contributor
Subject
Genre
Language
eng
Summary
"Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data."--Publisher's description
Member of
Cataloging source
N$T
Dewey number
615.50724
Illustrations
illustrations
Index
no index present
LC call number
R853.C55
LC item number
N387 2010eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2011 C-574
  • WA 950
http://bibfra.me/vocab/lite/organizationName
National Research Council (U.S.)
http://library.link/vocab/relatedWorkOrContributorName
National Research Council (U.S.)
http://library.link/vocab/subjectName
  • Clinical trials
  • Experimental design
  • Randomized Controlled Trials as Topic
  • Biomedical Research
  • HEALTH & FITNESS
  • MEDICAL
  • HEALTH & FITNESS
  • BODY, MIND & SPIRIT
  • Clinical trials
  • Experimental design
Label
The prevention and treatment of missing data in clinical trials, Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references (pages 115-122)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and background -- Trial designs to reduce the frequency of missing data -- Trial strategies to reduce the frequency of missing data -- Drawing inferences from incomplete data -- Principles and methods of sensitivity analyses -- Conclusions and recommendations
Control code
709748250
Dimensions
unknown
Extent
1 online resource (xv, 144 pages)
File format
unknown
Form of item
online
Isbn
9780309158152
Lccn
2012405185
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)709748250
Label
The prevention and treatment of missing data in clinical trials, Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references (pages 115-122)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction and background -- Trial designs to reduce the frequency of missing data -- Trial strategies to reduce the frequency of missing data -- Drawing inferences from incomplete data -- Principles and methods of sensitivity analyses -- Conclusions and recommendations
Control code
709748250
Dimensions
unknown
Extent
1 online resource (xv, 144 pages)
File format
unknown
Form of item
online
Isbn
9780309158152
Lccn
2012405185
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)709748250

Library Locations

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      38.710138 -90.311107
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