The Resource The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart, by Amol Modgi, (electronic resource)

The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart, by Amol Modgi, (electronic resource)

Label
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart
Title
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart
Statement of responsibility
by Amol Modgi
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Heart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium exchanger (NCX) is an important exchanger for calcium homeostasis. We hypothesize that the NCX may be present during development. To test this hypothesis we recorded the spontaneous electrical activity of heart from the embryonic chicken heart before and after blocking NCX during different stages of development with different concentration of KB-R7943. We found that the blocking of this exchanger does have significant effect on the amplitude and the rise time of AP. We found out that changes in duration of AP were less in atrium in early stages of development and increased during later stages of development. Interestingly these results were opposite in ventricles where increase in duration of AP was more during early stages of development and decreased during later stages of development. Similarly there was an increase in decay time of atrium and ventricular action potential at different stages of development. There were relatively few very significant changes in rise time of AP. Hence it is quite apparent that the blocking of NCX affects the plateau phase of AP or the calcium extrusion phase. It is also certain that NCX is one of the exchangers present in early embryonic hearts to actively play role in shaping the electrical activity
Cataloging source
MUU
http://library.link/vocab/creatorName
Modgi, Amol
Degree
M.S.
Dissertation year
2008.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Polo-Parada, Luis
http://library.link/vocab/subjectName
  • Chickens
  • Heart
  • Electrocardiography
  • Heart conduction system
Target audience
specialized
Label
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart, by Amol Modgi, (electronic resource)
Instantiates
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on September 25, 2009)
  • Thesis advisor: Dr. Luis Polo Parada
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
439892810
Extent
1 online resource (vii, 67 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)439892810
Label
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart, by Amol Modgi, (electronic resource)
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on September 25, 2009)
  • Thesis advisor: Dr. Luis Polo Parada
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
439892810
Extent
1 online resource (vii, 67 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)439892810

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