Coverart for item
The Resource Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development, Constanze Bonifer, Peter N. Cockerill, editors

Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development, Constanze Bonifer, Peter N. Cockerill, editors

Label
Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development
Title
Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development
Statement of responsibility
Constanze Bonifer, Peter N. Cockerill, editors
Contributor
Editor
Subject
Language
eng
Summary
In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders
Member of
Cataloging source
GW5XE
Dewey number
571.9/6
Illustrations
illustrations
Index
index present
LC call number
QH450
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QU 460
http://library.link/vocab/relatedWorkOrContributorName
  • Bonifer, Constanze
  • Cockerill, Peter N.
Series statement
Epigenetics and Human Health,
http://library.link/vocab/subjectName
  • Epigenetics
  • Blood cells
  • Blood
  • Epigenomics
  • SCIENCE
  • Blood cells
  • Blood
  • Epigenetics
Label
Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development, Constanze Bonifer, Peter N. Cockerill, editors
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Bibliography note
ReferencesChapter 3: Epigenetic and Transcriptional Mechanisms Regulating Blood Cell Development in Zebrafish; 3.1 Introduction; 3.2 Overview of Zebrafish Hematopoiesis; 3.3 Genetic and Epigenetic Regulation of Zebrafish Hematopoiesis; 3.3.1 Transcriptional Control of the Emergence of Hematopoietic Cells in Early Embryos; 3.3.2 Regulation of Definitive HSC Formation; 3.3.3 Regulation of Lineage Specification; 3.3.4 Epigenetic Regulators in Zebrafish Hematopoiesis; 3.4 Blood Disease Modeling Using Zebrafish; 3.5 Conclusions and Future Perspectives; References
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function
Control code
874923879
Dimensions
unknown
Extent
1 online resource (xiii, 416 pages)
File format
unknown
Form of item
online
Isbn
9783642451997
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-642-45198-0
Other physical details
color illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)874923879
Label
Transcriptional and epigenetic mechanisms regulating normal and aberrant blood cell development, Constanze Bonifer, Peter N. Cockerill, editors
Publication
Note
Includes index
Antecedent source
unknown
Bibliography note
ReferencesChapter 3: Epigenetic and Transcriptional Mechanisms Regulating Blood Cell Development in Zebrafish; 3.1 Introduction; 3.2 Overview of Zebrafish Hematopoiesis; 3.3 Genetic and Epigenetic Regulation of Zebrafish Hematopoiesis; 3.3.1 Transcriptional Control of the Emergence of Hematopoietic Cells in Early Embryos; 3.3.2 Regulation of Definitive HSC Formation; 3.3.3 Regulation of Lineage Specification; 3.3.4 Epigenetic Regulators in Zebrafish Hematopoiesis; 3.4 Blood Disease Modeling Using Zebrafish; 3.5 Conclusions and Future Perspectives; References
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function
Control code
874923879
Dimensions
unknown
Extent
1 online resource (xiii, 416 pages)
File format
unknown
Form of item
online
Isbn
9783642451997
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-642-45198-0
Other physical details
color illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)874923879

Library Locations

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      38.710138 -90.311107
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